Patents by Inventor Michael HOARE

Michael HOARE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210361570
    Abstract: The present application relates to in situ gelling hydrogel structures formed by the crosslinking of polysaccharide-based nanoparticles and functional polymers. Such systems can be designed to release the nanoparticles and/or encapsulated therapeutics either over time or in response to environmental stimuli.
    Type: Application
    Filed: May 18, 2021
    Publication date: November 25, 2021
    Inventors: Todd Hoare, Ali Babar, Michael J. Majcher, Xiaoyun Li, Andrew D. Lofts, Matthew A. Campea
  • Patent number: 11098312
    Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: August 24, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Robyn Alexandra Emmins, Gary Brian Finka, Michael Hoare, Alan Peter Lewis, William John Kenneth Lewis, Adam Daniel McInally, Mark Uden, Ioannis Voulgaris
  • Publication number: 20190177734
    Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.
    Type: Application
    Filed: May 4, 2017
    Publication date: June 13, 2019
    Inventors: Robyn Alexandra EMMINS, Gary Brian FINKA, Michael HOARE, Alan Peter LEWIS, William John Kenneth LEWIS, Adam Daniel McINALLY, Mark UDEN, Ioannis VOULGARIS
  • Publication number: 20190132112
    Abstract: There is a communications network node comprising a transmitter or a receiver configured to communicate with a plurality of other nodes via an interconnection medium interconnecting the node and the other nodes. The node is frequency synchronized with regard to signal transmission or reception, via a frequency synchronization mechanism, with at least one of the other nodes. The node has at least one store holding phase data relating to an amount of phase asynchrony and path characteristics between the node and at least one of the other nodes. A phase controller uses the stored data to adjust phase used by the node such that the recovery of data when communicating with at least one other node is facilitated.
    Type: Application
    Filed: December 28, 2017
    Publication date: May 2, 2019
    Inventors: Hitesh BALLANI, Paolo COSTA, Hugh David Paul WILLIAMS, István HALLER, Krzysztof JOZWIK, Benn Charles THOMSEN, Kari Aaron CLARK, Adam Christopher FUNNELL, Philip Michael WATTS, Kai SHI, Thomas Michael Hoare GERARD
  • Publication number: 20180135008
    Abstract: The present invention relates to a method of producing a recombinant protein in a host cell comprising adding Polyethyleneimine (PEI) during cell culture. Addition of PEI to the cell culture as a fermentation enhancer can result in reducing the viscosity of the cell culture, and/or increasing the extracellular concentration of the recombinant protein, and/or reducing the duration of cell culture to the point of harvest or protein recovery.
    Type: Application
    Filed: May 13, 2016
    Publication date: May 17, 2018
    Inventors: Gary Brian FINKA, Michael HOARE, Mark UDEN, Ioannis VOULGARIS
  • Publication number: 20150368292
    Abstract: The present invention relates to a method of producing a recombinant protein by harvesting a microbial cell broth and adding an amount of a flocculant to achieve an effective particle size distribution. The present invention also relates to a method of clarifying a microbial harvest by adding an amount of a flocculant to achieve an effective particle size distribution.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 24, 2015
    Applicant: GLAXO GROUP LIMITED
    Inventors: Alex CHATEL, Michael HOARE, Peter KUMPALUME, Jessica Rachel MOLEK, Jason Michael RECK, Andrew David WEBER