Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling in sequenced operations with utilization of phase change materials to form an impervious layer at the wellbore/formation interface in high temperature applications. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for heat transfer surfaces for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.

Abstract: A method includes causing a first portion of a heat-transfer working fluid to flow from a first lateral wellbore of a closed-loop geothermal well to a second lateral wellbore of the closed-loop geothermal well via a wellbore intersection. The first lateral wellbore and the second lateral wellbore reside in a target subterranean zone. A second portion of the heat-transfer working fluid is caused to flow through the Earth of the target subterranean zone from the first lateral wellbore to the second lateral wellbore.

Abstract: A method includes circulating a heat transfer working fluid in a closed loop between a geothermal well residing in a subterranean zone and at least one of a heat exchanger or a turbine. The well is substantially sealed to limit fluid loss of the working fluid into the subterranean zone. While circulating the working fluid, at least one of a viscosity of the working fluid or a pressure differential between the working fluid and the subterranean zone is controlled in relation to a flow of fluid between the subterranean zone and the well.

Abstract: A bladeset for a hair clipper has a stationary blade with a plurality of stationary blade teeth defined along a stationary blade lateral axis and includes first and second outermost stationary blade teeth. A stationary blade midpoint is defined between the first and second outermost stationary blade teeth. The bladeset also has a moving blade with a plurality of moving blade teeth defined along a moving blade lateral axis and includes first and second outermost moving blade teeth. A moving blade midpoint is defined between the first and second outermost moving blade teeth. Preferably, each of the stationary blade teeth and the moving blade teeth define a rake angle along at least one edge of each tooth, and the rake angles of at least one of the stationary blade teeth and the moving blade teeth change gradually from the corresponding blade midpoint to the corresponding outermost tooth.

Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling in sequenced operations with utilization of phase change materials to form an impervious layer at the wellbore/formation interface in high temperature applications. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for heat transfer surfaces for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.

Abstract: A method for drilling a geothermal well in a subterranean zone includes drilling, with a drill string, a wellbore of the geothermal well in the subterranean zone. An inherent temperature of the rock adjacent a rock face at a downhole end of the wellbore is at least 250 degrees Celsius. While drilling, a drilling fluid is flowed at a temperature at the rock face such that a difference between the inherent temperature of the rock adjacent the rock face and the temperature of the drilling fluid at the rock face is at least 100 degrees Celsius.

Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling in sequenced operations with utilization of phase change materials to form an impervious layer at the wellbore/formation interface in high temperature applications. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for heat transfer surfaces for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.

Abstract: The present disclosure provides populations of genetically modified hepatocytes and/or hepatocyte progenitors and methods of producing the same. Methods of using said populations of genetically modified hepatocytes and/or progenitors, such as, but not limited to, treating a subject or a plurality of subjects for a condition or a plurality of conditions, are also provided. In some instances, genetically modified hepatocytes and/or hepatocyte progenitors of the population are hypoimmunogenic and the methods include methods of generating hypoimmunogenic hepatocytes and/or progenitors thereof. Non-human mammals containing engrafted populations of genetically modified hepatocytes and/or hepatocyte progenitors are also provided. Useful kits, systems, reagents, cells, and cell therapy doses are also provided.

Abstract: A method includes circulating a heat transfer working fluid in a closed loop between a geothermal well residing in a subterranean zone and at least one of a heat exchanger or a turbine. The well is substantially sealed to limit fluid loss of the working fluid into the subterranean zone. While circulating the working fluid, at least one of a viscosity of the working fluid or a pressure differential between the working fluid and the subterranean zone is controlled in relation to a flow of fluid between the subterranean zone and the well.

Abstract: Provided are isolated expanded human hepatocytes and methods of producing isolated expanded human hepatocytes. In certain embodiments, the methods comprise introducing human hepatocytes into the liver of a non-human in vivo bioreactor, expanding the human hepatocytes in the liver of the non-human in vivo bioreactor, and collecting hepatocytes from the liver of the non-human in vivo bioreactor. The collected hepatocytes comprise a xenomixture of expanded human hepatocytes and non-human in vivo bioreactor cells, including hepatocytes endogenous to the in vivo bioreactor. Such methods may further comprise subjecting the xenomixture to centrifugal elutriation under conditions sufficient to produce an elutriation fraction enriched for the expanded human hepatocytes, and/or removing non-human in vivo bioreactor cells from the elutriation fraction via a negative selection process. Also provided are isolated expanded human hepatocytes produced according to such methods.

Abstract: A method for drilling a geothermal well in a subterranean zone includes drilling, with a drill string, a wellbore of the geothermal well in the subterranean zone. An inherent temperature of the rock adjacent a rock face at a downhole end of the wellbore is at least 250 degrees Celsius. While drilling, a drilling fluid is flowed at a temperature at the rock face such that a difference between the inherent temperature of the rock adjacent the rock face and the temperature of the drilling fluid at the rock face is at least 100 degrees Celsius.

Abstract: Disclosed are compounds of Formula 1, all stereoisomers, N-oxides, and salts thereof, wherein G is CONR5R6 or selected from and R1 through R18, Rf and G are as defined in the Disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Abstract: A method for drilling a geothermal well in a subterranean zone includes drilling, with a drill string, a wellbore of the geothermal well in the subterranean zone. An inherent temperature of the rock adjacent a rock face at a downhole end of the wellbore is at least 250° C. While drilling, a drilling fluid is flowed at a temperature at the rock face such that a difference between the inherent temperature of the rock adjacent the rock face and the temperature of the drilling fluid at the rock face is at least 100° C.

Abstract: Methods for drilling in higher temperature rock formations such as geothermal formations with phase change material augmented drilling fluid include observing flow rate of the augmented fluid. Heat exchange between the annulus returning fluid and tubular fluid can be minimized thereby facilitating a cooler fluid for contact with a rock face being drilled. The cooling assists in pre-fracturing the rock face prior to destruction by the drill bit.

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R1, X, Q, R2, n, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.

Abstract: A bladeset for a hair clipper has a stationary blade with a plurality of stationary blade teeth defined along a stationary blade lateral axis and includes first and second outermost stationary blade teeth. A stationary blade midpoint is defined between the first and second outermost stationary blade teeth. The bladeset also has a moving blade with a plurality of moving blade teeth defined along a moving blade lateral axis and includes first and second outermost moving blade teeth. A moving blade midpoint is defined between the first and second outermost moving blade teeth. Preferably, each of the stationary blade teeth and the moving blade teeth define a rake angle along at least one edge of each tooth, and the rake angles of at least one of the stationary blade teeth and the moving blade teeth change gradually from the corresponding blade midpoint to the corresponding outermost tooth.

Abstract: A bandage-type apparatus includes a skin condition compartment that is adhered to cover a skin condition with leak-proof adhesive surrounding the compartment that attaches to skin adjacent the skin condition and with a non-adhesive material of the compartment covering the skin condition. A liquid pouch or container with a releasable liquid is coupled to the skin condition compartment and configured for the liquid, such as saline solution, to be released into the compartment to provide a bath or soak in the leak-proof, body-adhered skin condition compartment to provide treatment or relief to the skin condition, such as a sore nipple of a breastfeeding mother.

Abstract: An electric propulsion module coupled to a spacecraft capable of providing thrust at a level required for multi-burn orbit transfer is disclosed herein. The electric propulsion system includes an electric propulsion thruster, a propellant tank and an energy storage device. In one form the energy storage device is a battery operable to provide sufficient power to maneuver the spacecraft quickly to avoid space debris and/or move to a different orbit through a multi-burn thrust procedure.

Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling in sequenced operations with utilization of phase change materials to form an impervious layer at the wellbore/formation interface in high temperature applications. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for heat transfer surfaces for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.