Abstract: Provided herein is a metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. The metered dose inhaler contains a diaphragm which includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: A metered dose aerosol actuator, for use in association with a pressurized medicament container provided with a dispensing metering valve having a valve stem, including a housing adapted to receive the container, a stem block extending upwards from the base of the housing and adapted to engage the valve stem by means of a cavity provided in the stem block, the stem block being provided with a spray orifice adapted to be in flow connection with the valve stem and the cavity, a sump extending downwards from the cavity relative to the spray orifice, wherein the sump has a smooth, rounded interior surface.

Abstract: A metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. A preload is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force. The inhaler comprises a release device which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve. A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region defined in part by a diaphragm. The diaphragm includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: A metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. A preload is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force. The inhaler comprises a release device which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve. A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region defined in part by a diaphragm. The diaphragm includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: An apparatus for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms includes a mixer for mixing a sump of the powder material to electrostatically charge the powder material, the mixer including two substantially parallel elongate mixing shafts having oppositely angled mixing paddles thereon and being arranged to rotate in opposite directions; and a feeder for removing the electrostatically charged powder material from the sump and supplying it to the applicator, and a method for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms.

Abstract: A metered dose aerosol actuator, for use in association with a pressurised medicament container (3) provided with a dispensing metering valve having a valve stem (4), comprising a housing (1) adapted to receive the container (3), a stem block (5), extending upwards from the base of the housing (2) and adapted to engage the valve stem (4) by means of a cavity (6) provided in the stem block (5), the stem block being provided with a spray orifice (9) adapted to be in flow connection with the valve stem (4) and the cavity, a sump (8) extending downwards from the cavity (6), relative to the spray orifice (9), wherein the sump (8) has a smooth, rounded interior surface.

Abstract: A metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. A preload (80) is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force (130). The inhaler comprises a release device (110) which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve (135). A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region defined in part by a diaphragm. The diaphragm includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: This invention relates to activated charcoal granule compositions which can be dry spread and "watered-in" to a site to reduce undesirable biological activity of deleterious organic compounds. When wet, these granules disperse very rapidly with a large dispersion area to original granule diameter ratio. The granules have high loadings of charcoal, i.e., from about 60 to about 95 weight percent and contain from about 5 to about 40 weight percent of a surfactant system which exhibits excellent dispersing; rewetting; and binding properties.

Abstract: This invention relates to the use of activated charcoal granule compositions which, when dry spread and "watered-in" to a site, reduces undesirable biological activity of deleterious organic compounds. When wet, these granules disperse very rapidly with a large dispersion area to original granule diameter ratio. The granules have high loadings of charcoal, i.e., from about 60 to about 95 weight percent and contain from about 5 to about 40 weight percent of a surfactant system which exhibits excellent dispersing; rewetting; and binding properties.

Abstract: Methods and apparatus enabling a diagnostic test to be carried out on milk flowing in a milk line from an animal being milked, without interrupting the milking process, in which a portion of the milk is diverted through a by-pass in which an extracting means (14) in the form of a vacuum-operable pump and timer acts to separate from the milk flowing in the by-pass a milk sample and to deliver said sample through an associated sampling valve (16) to a testing device (18).

Abstract: Methods and apparatus enabling a diagnostic test to be carried out on milk flowing in a milk line from an animal being milked, without interrupting the milking process, in which a portion of the milk is diverted through a by-pass in which an extracting means (14) in the form of a vacuum-operable pump and timer acts to separate from the milk flowing in the by-pass a milk sample and to deliver said sample through an associated sampling valve (16) to a testing device (18).