Abstract: The instant application provides methods and related compositions pertaining to the identification of resistance to anticancer treatment in a patient. In a particular embodiment, the invention provides biomarkers for the identification of resistance to anticancer treatment in a lung cancer patient, wherein a reduced expression of a MEDIATOR and/or SW1/SNF complex gene in the lung cancer cells of the patient indicates that the lung cancer cells in the patient may be resistant to treatment with a receptor tyrosine kinase inhibitor, such as gefitinib and/or erlotinib. In some embodiments, the invention relates to methods and related compositions for predicting resistance to anticancer treatment by detecting the expression levels of one or more TGF-beta pathway nucleic acids and/or proteins.

Abstract: The instant application provides methods and related compositions pertaining to the identification of resistance to anticancer treatment in. a patient. In a particular embodiment, the invention provides biomarkers for the identification of resistance to anticancer treatment in a breast cancer patient, wherein a reduced expression of a MEDIATOR and/or SWI/SNF complex gene in the breast cancer cells of the patient indicates that the breast cancer cells in the patient may be successfully treated with a PI3K and/or mTOR inhibitor.

Abstract: The present invention is directed to a pneumatic tire comprising a composite tread band disposed radially about a tire carcass; the composite tread band comprising a unitary semibase portion coextruded with at least one cap portion; the unitary semibase portion at its radially innermost extent axially spanning the composite tread band; the unitary semibase portion comprising at least one non-ground contacting zone, and at least one ground-contacting zone extending over from about 20 to about 80 percent of the axial span of the tread band;the at least one cap portion being ground-contacting and overlaying the at least one non-ground contacting zone of the unitary semibase portion.