Abstract: This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.

Abstract: A video picture is divided into a plurality of columns, each column covering only a part of the video picture in a horizontal dimension. All coded tree blocks (“CTBs”) belonging to a slice may belong to one or more columns. The columns may be used to break the same or different prediction or in-loop filtering mechanisms of the video coding, and the CTB scan order used for encoding and/or decoding may be local to a column. Column widths may be indicated in a parameter set and/or may be adjusted at the slice level. At the decoder, column width may be parsed from the bitstream, and slice decoding may occur in one or more columns.

Abstract: A video coding device may be configured to perform video coding comprising: receiving a video block including sample values for a first component of video data and a second component of video data; partitioning the sample values for the first component of video data and the second component of video data according to a first quad tree binary tree (QTBT) partitioning structure; and for samples values of the first component of video data included in nodes of the first quad tree binary tree associated with an intra prediction type, further partitioning the samples according to a second quad tree binary tree.

Abstract: Systems and methods for facilitating shared access-right evaluation using linked communication channels are provided. A first communication can be received over a first communication link from a first user device, and a second communication can be received over a second communication link from a second user device. The first and second communications can include requests for the assignment of access rights. Map data can be generated and transmitted to each of the first and second user devices. Each user device can display a visual representation of access-right data. Further, a communication session can be facilitated between the first user device and the second user device. The communication session can be presented on the visual representation for each user device so that the first user and the second user can collaboratively evaluate access rights.

Abstract: A method includes receiving an input video stream and scaling the input video stream into two or more spatial layers. For each spatial layer, the method also includes generating a temporal layer prediction pattern by: obtaining a temporal base layer for a corresponding spatial layer; identifying, based on the temporal base layer, a plurality of temporal layers and a plurality of temporal time slots during a temporal period; and aligning the temporal base layer for the corresponding spatial layer with one of the temporal time slots during the temporal period. Each temporal time slot is associated with one of the temporal base layer or one of the plurality of temporal layers for the corresponding spatial layer. The temporal base layer for each corresponding spatial layer is aligned with a different temporal time slot than each other temporal base layer for each other corresponding spatial layer.

Abstract: A method and apparatus for adaptive denoising of source video in a video conference application is provided. Source video frames received from a video capture device are divided into a plurality of 16×16 blocks. For each source block, a moving object detection process and a noise estimation process are performed. Then temporal denoising is adaptively applied to the blocks of the source frame based on the noise estimation and moving object detection. The adaptively filtered blocks are provided to an output frame and forwarded to a coding module for encoding.

Abstract: A method includes receiving an input video stream and scaling the input video stream into two or more spatial layers. For each spatial layer, the method also includes generating a temporal layer prediction pattern by: obtaining a temporal base layer for a corresponding spatial layer; identifying, based on the temporal base layer, a plurality of temporal layers and a plurality of temporal time slots during a temporal period; and aligning the temporal base layer for the corresponding spatial layer with one of the temporal time slots during the temporal period. Each temporal time slot is associated with one of the temporal base layer or one of the plurality of temporal layers for the corresponding spatial layer. The temporal base layer for each corresponding spatial layer is aligned with a different temporal time slot than each other temporal base layer for each other corresponding spatial layer.

Abstract: A video coding device may be configured to perform video coding according to one or more of the techniques described herein. In one example, a method of partitioning video data for video coding, comprises receiving a video block including sample values, and partitioning the sample values according to the following set of partitioning modes: quadtree, horizontal or vertical symmetric binary tree, horizontal or vertical asymmetric binary tree, and horizontal or vertical triple tree.

Abstract: A video coding device may be configured to perform video coding according to one or more of the techniques described herein. In one example, a method of coding of video data comprises determining a predictive quantization parameter for an array of level values based at least in part on one or more of: a picture quantization map and a quantization parameter value of a video block included in a reference picture, generating a quantization parameter for the array based at least in part on the determined predictive quantization parameter, and performing an inverse quantization operation on the array using the generated quantization parameter.

Abstract: Systems and methods for facilitating shared access-right evaluation using linked communication channels are provided. A first communication can be received over a first communication link from a first user device, and a second communication can be received over a second communication link from a second user device. The first and second communications can include requests for the assignment of access rights. Map data can be generated and transmitted to each of the first and second user devices. Each user device can display a visual representation of access-right data. Further, a communication session can be facilitated between the first user device and the second user device. The communication session can be presented on the visual representation for each user device so that the first user and the second user can collaboratively evaluate access rights.

Abstract: A method of partitioning video data for video coding is disclosed. The method comprises receiving a video block which includes sample values for a component of video data, partitioning the video block according to a partitioning line which is defined according to an angle and an distance, and signaling the partitioning line based on allowed values for the angle and the distance. The allowed values are based on one or more of properties of video data or video coding parameters.

Abstract: A method and apparatus for adaptive denoising of source video in a video conference application is provided. Source video frames received from a video capture device are divided into a plurality of 16×16 blocks. For each source block, a moving object detection process and a noise estimation process are performed. Then temporal denoising is adaptively applied to the blocks of the source frame based on the noise estimation and moving object detection. The adaptively filtered blocks are provided to an output frame and forwarded to a coding module for encoding.

Abstract: A method includes receiving an input video stream and scaling the input video stream into two or more spatial layers. For each spatial layer, the method also includes generating a temporal layer prediction pattern by: obtaining a temporal base layer for a corresponding spatial layer; identifying, based on the temporal base layer, a plurality of temporal layers and a plurality of temporal time slots during a temporal period; and aligning the temporal base layer for the corresponding spatial layer with one of the temporal time slots during the temporal period. Each temporal time slot is associated with one of the temporal base layer or one of the plurality of temporal layers for the corresponding spatial layer. The temporal base layer for each corresponding spatial layer is aligned with a different temporal time slot than each other temporal base layer for each other corresponding spatial layer.

Abstract: A method includes receiving transform coefficients corresponding to a scaled video input signal, the scaled video input signal including a plurality of spatial layers that include a base layer. The method also includes determining a spatial rate factor based on a sample of frames from the scaled video input signal. The spatial rate factor defines a factor for bit rate allocation at each spatial layer of an encoded bit stream formed from the scaled video input signal. The spatial rate factor is represented by a difference between a rate of bits per transform coefficient of the base layer and an average rate of bits per transform coefficient. The method also includes reducing a distortion for the plurality of spatial layers by allocating a bit rate to each spatial layer based on the spatial rate factor and the sample of frames.

Abstract: A method and apparatus for adaptive denoising of source video in a video conference application is provided. Source video frames received from a video capture device are divided into a plurality of 16×16 blocks. For each source block, a moving object detection process and a noise estimation process are performed. Then temporal denoising is adaptively applied to the blocks of the source frame based on the noise estimation and moving object detection. The adaptively filtered blocks are provided to an output frame and forwarded to a coding module for encoding.

Abstract: A secure dispute settlement system is described. The secure dispute settlement system may receive first injury data associated with first injuries of an injured party. The secure dispute settlement system may identify, based on the first injury data, historical settlement data associated with a historical settlement. The historical settlement data may indicate second injury data associated with second injuries that are similar to the first injuries, and a value that the second injuries were settled for. The secure dispute settlement system may generate, based on the historical settlement, a settlement report that indicates an estimated fair value for the first injuries.

Abstract: Described is picture segmentation through columns and slices in video encoding and decoding. A video picture is divided into a plurality of columns, each column covering only a part of the video picture in a horizontal dimension. All coded tree blocks (“CTBs”) belonging to a slice may belong to one or more columns. The columns may be used to break the same or different prediction or in-loop filtering mechanisms of the video coding, and the CTB scan order used for encoding and/or decoding may be local to a column. Column widths may be indicated in a parameter set and/or may be adjusted at the slice level. At the decoder, column width may be parsed from the bitstream, and slice decoding may occur in one or more columns.

Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.

Abstract: Systems and methods for picture segmentation through columns and slices in video encoding and decoding. A video picture is divided into a plurality of columns, each column covering only a part of the video picture in a horizontal dimension. All coded tree blocks (“CTBs”) belonging to a slice may belong to one or more columns. The columns may be used to break the same or different prediction or in-loop filtering mechanisms of the video coding, and the CTB scan order used for encoding and/or decoding may be local to a column. Column widths may be indicated in a parameter set and/or may be adjusted at the slice level. At the decoder, column width may be parsed from the bitstream, and slice decoding may occur in one or more columns.

Abstract: Systems and methods for facilitating shared access-right evaluation using linked communication channels are provided. A first communication can be received over a first communication link from a first user device, and a second communication can be received over a second communication link from a second user device. The first and second communications can include requests for the assignment of access rights. Map data can be generated and transmitted to each of the first and second user devices. Each user device can display a visual representation of access-right data. Further, a communication session can be facilitated between the first user device and the second user device. The communication session can be presented on the visual representation for each user device so that the first user and the second user can collaboratively evaluate access rights.