Patents by Inventor Michael Houghton

Michael Houghton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190231867
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Application
    Filed: October 5, 2017
    Publication date: August 1, 2019
    Inventors: Michael Houghton, Abdolamir Landi
  • Publication number: 20190224308
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 25, 2019
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
  • Publication number: 20190209677
    Abstract: The present disclosure provides an immunogenic composition comprising: a) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; b) a T-cell epitope polypeptide comprising a T-cell epitope present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide. The present disclosure provides an immunogenic composition comprising: a) a polypeptide that comprises one or more T-cell epitopes present in an HCV protein other than E1 and E2; and b) a pharmaceutically acceptable excipient.
    Type: Application
    Filed: September 21, 2017
    Publication date: July 11, 2019
    Inventors: Michael Houghton, Abdolamir Landi, Michael Logan, John L. Law, Darren Hockman, Chao Chen
  • Patent number: 10300131
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: May 28, 2019
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
  • Patent number: 10290953
    Abstract: An electrical connector for a glazing comprising a connector portion for connection to an electrical supply, and a button for soldering to a surface of the glazing, the button comprising a base portion adjacent, in use, to the surface of the glazing and an upper portion remote, in use, from the surface of the glazing, wherein the button comprises at least one solder-contacting surface, at least a portion of the solder-contacting surface curving from the base portion to the upper portion and defining a tapering solder cavity. A glazing comprising the electrical connector is also disclosed as is a method of soldering the electrical connector to a glazing.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: May 14, 2019
    Assignee: PILKINGTON GROUP LIMITED
    Inventors: Michael Lyon, Julie Houghton, Jonathan Mark Williams, Paul Andrew Skinner
  • Patent number: 10159499
    Abstract: Reamer sleeves, reamer assemblies, and methods of assembling the reamer assemblies are disclosed. The reamer sleeves include a base portion with a top surface and a bottom surface and a securement mechanism extending away from the top surface of the base portion. The securement mechanism includes an opening, at least one engagement member adjacent the opening, and at least one engagement protrusion extending away from the engagement member into the opening. The opening extends through the securement mechanism to the bottom surface of the base portion. The bone reamer assembly including a reamer and a reamer sleeve removably coupled to the reamer. The reamer including a shaft with a first and second end, a cutting member coupled to the second end of the shaft, and a groove near the second end of the shaft. A method of assembling a hard tissue reamer assembly is also disclosed.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: December 25, 2018
    Assignee: PARAGON 26, INC.
    Inventors: Albert Dacosta, Matthew S. Solar, Thomas Chang, Michael Houghton
  • Publication number: 20180282377
    Abstract: The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) E1 polypeptide and an HCV E2 polypeptide, where one or both of the E1 and E2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged E1/E2 heterodimer of the present disclosure. The present disclosure provides methods of producing untagged HCV E1/E2 heterodimers. The present disclosure provides HCV E1/E2 heterodimers, compositions comprising same, and methods of inducing an immune response to HCV.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 4, 2018
    Inventors: Michael Houghton, Darren Hockman, John L. Law, Chao Chen, Michael Logan
  • Patent number: 10064631
    Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: September 4, 2018
    Assignee: Paragon 28, Inc.
    Inventors: Albert Dacosta, Matthew S. Solar, Thomas Chang, Michael Houghton
  • Publication number: 20180209992
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Application
    Filed: March 15, 2018
    Publication date: July 26, 2018
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Publication number: 20180193039
    Abstract: Fixation guide devices and methods for positioning and inserting an intramedullary nail are disclosed. The fixation guide devices include a frame with a first end and a second end, a compression device removably coupled to the first end of the frame, and the intramedullary nail secured to a nail attachment apparatus of the frame. An intramedullary nail including a body with a fastening end, a closed end, and at least two openings is also disclosed. A compression device includes a compression member, a knob, and a bolt secured in the knob and rotatably engaging the compression member is also disclosed. An alignment guide is disclosed and includes a base member, an alignment member, and a fixation guide. A method of inserting an intramedullary nail into two bones for fixation of the two bones is also disclosed.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 12, 2018
    Applicant: Paragon 28, Inc.
    Inventors: Albert DACOSTA, Frank BONO, Michael HOUGHTON, Thomas SANGIOVANNI, James T. CLANCY, Thomas CHANG
  • Publication number: 20180169219
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Application
    Filed: July 6, 2016
    Publication date: June 21, 2018
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
  • Publication number: 20180154121
    Abstract: The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.
    Type: Application
    Filed: January 29, 2018
    Publication date: June 7, 2018
    Inventors: Alex R. Hobson, Michael Houghton, David R. King, Joseph E. Korleski, JR., Brian C. Lentz, Kenneth Newcomb, Peter J. Roeber, John Streeter
  • Publication number: 20180132868
    Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 17, 2018
    Applicant: Paragon 28, Inc.
    Inventors: Albert DACOSTA, Matthew S. SOLAR, Thomas CHANG, Michael HOUGHTON
  • Patent number: 9962209
    Abstract: A method for fusing bones using a guide pin and a fastener is disclosed. The method includes inserting a guide pin into two bones. The guide pin including at least one radial marking. The method also including imaging the two bones and guide pin and analyzing the position of the at least one radial marking of the guide pin relative to the two bones. In addition, the method includes selecting a fastener, inserting a drill over the guide pin, drilling an opening through at least one of the two bones, and inserting the fastener into the opening. The guide pin may include an exterior surface with a first end and a second end, a cutting edge at the first end, and at least one radial marking near the first end. A system including a guide pin, a fastener, and a drill is also disclosed.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: May 8, 2018
    Assignee: PARAGON 28, INC.
    Inventors: Albert Dacosta, Thomas San Giovanni, Michael Houghton
  • Patent number: 9952226
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: April 24, 2018
    Assignees: Medizinische Hochschule Hannover, The Governors of the University of Alberta
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Patent number: 9949773
    Abstract: The present invention discloses an orthopedic bone plate and locking tab apparatus and method of use. The orthopedic plate includes a body with a first end, a second end, and a central portion extending between the first end and the second end, a first pair of lobes at the first end, a second pair of lobes at the second end, and a securing mechanism extending away from a bottom surface of the central portion. The securing mechanism includes a base portion projecting from the body portion of the bone plate and two opposing extension members projecting from the base portion. A method for inserting the bone plate is also disclosed.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 24, 2018
    Assignee: PARAGON 28, INC.
    Inventors: Albert Dacosta, Thomas Sangiovanni, Michael Houghton
  • Publication number: 20180068053
    Abstract: Provided herein are systems and methods for selecting compounds that have reduced risk of cardiotoxicity or which are not likely to be cardiotoxic. As an example, a system and method can include a computational dynamic model combined with a high throughput screening in silico that mimics an important ion channels associated with cardiotoxicity, namely the human cardiac sodium ion (hNav1.5) channel). In certain embodiments, steered molecular dynamics simulations are used to identify key residues of the channel's permeation pathways that are then used in the high throughput screening. Also provided herein are systems and methods for redesigning compounds that are predicted to be cardiotoxic based on the model and the high throughput screening.
    Type: Application
    Filed: August 4, 2017
    Publication date: March 8, 2018
    Inventors: Khaled BARAKAT, Marawan AHMED, Aravindhan GANESAN, Michael HOUGHTON, Lorne TYRRELL
  • Patent number: 9907562
    Abstract: Fixation guide devices and methods for positioning and inserting an intramedullary nail are disclosed. The fixation guide devices include a frame with a first end and a second end, a compression device removably coupled to the first end of the frame, and the intramedullary nail secured to a nail attachment apparatus of the frame. An intramedullary nail including a body with a fastening end, a closed end, and at least two openings is also disclosed. A compression device includes a compression member, a knob, and a bolt secured in the knob and rotatably engaging the compression member is also disclosed. An alignment guide is disclosed and includes a base member, an alignment member, and a fixation guide. A method of inserting an intramedullary nail into two bones for fixation of the two bones is also disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 6, 2018
    Assignee: PARAGON 28, INC.
    Inventors: Albert DaCosta, Frank Bono, Michael Houghton, Thomas Sangiovanni, James T. Clancy, Thomas Chang
  • Patent number: 9878133
    Abstract: The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: January 30, 2018
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Alex R. Hobson, Michael Houghton, David R. King, Joseph E. Korleski, Jr., Brian C. Lentz, Kenneth Newcomb, Peter J. Roeber, John Streeter
  • Publication number: 20180011110
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in a subject. The methods and compositions involve measurement of at least one of proteins: IL-16, IL-7, VEGF, CXCL9, CX3CL1, CCL24, CCL19, and CCL11 in a body fluid sample of a subject suspected of having CFS/ME. Levels of one or more of the aforementioned proteins can be used to facilitate a diagnosis of a CFS/ME and/or confirm a diagnosis of CFS/ME. The methods and compositions of the present disclosure also find use in screening subjects for clinical trials and facilitating treatment decisions for a subject.
    Type: Application
    Filed: January 26, 2016
    Publication date: January 11, 2018
    Inventors: Abdolamir Landi, David Broadhurst, D. Lorne J. Tyrrell, Michael Houghton