Abstract: The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.

Abstract: The present invention provides new dental care products comprising stannous fluoride and at least 0.01 wt % self-assembling peptides, wherein the self-assembling peptides are essentially present in the dental care product in assembled form. The assembled peptides form a three-dimensional matrix capable of stabilizing stannous fluoride by protecting it from oxidation. The dental care products may further comprise polyphosphates such as sodium tripolyphosphates as well as a tin chelating agent such as sodium gluconate. They may be provided in the form of a dental gel, a toothpaste, a tooth foam, dental rinse or a prophylactic paste. Also disclosed are methods for stabilizing stannous fluoride in a dental care product. Finally, the present invention relates to therapeutic methods for protecting a tooth from demineralization, for remineralizing the tooth enamel of a non-cavitated tooth lesion, for destroying biofilm formed on tooth and for treating dentinal hypersensitivity.

Abstract: A process for producing a lithium titanium phosphate based solid electrolyte material is disclosed, the process comprising the steps of: (i) providing a solution comprising a Li source material, a Ti source material, a P source material and optionally a Si source material and/or a source material of a metal M, wherein M is selected from the group of Al, Ga, Ge, In, Sc, V, Cr, Mn, Co, Fe, Y, the lanthanides or a combination thereof; (ii) generating an aerosol from the solution; (iii) subjecting the generated aerosol to flame pyrolysis to form a particulate precursor material therefrom; and (iv) subjecting the particulate precursor material to field-assisted sintering to form the lithium titanium phosphate based solid electrolyte material. Furthermore, disclosed are a solid electrolyte material obtainable through said production process and articles comprising the same.

Abstract: The present invention relates to the field of medicinal tissue mineralisation, in particular, i.e. tooth remineralisation and bone regeneration with self-assembling peptides. Use of self-assembling peptides, such as P11-4, also designated Oligopeptide-104, in these processes leads to generation of hydroxyapatite, which is also present in natural enamel, dentin and bone. The inventors have discovered that both tooth remineralisation and bone regeneration can be significantly accelerated by adding amorphous calcium phosphate or calcium and phosphate ions that, when mixed in solution, can lead to immediate precipitation of calcium phosphate, preferably, amorphous, i.e., non-crystalline calcium phosphate. The presence of self-assembling peptide however changes the structure of the precipitated calcium phosphate, and advantageously induces crystallisation and a synergistic accelerated formation of crystalline calcium phosphate, in particular, hydroxyapatite (HA).

Abstract: The present invention provides new dental care products comprising self-assembling peptides that are capable of undergoing self-assembly at a certain pH that are useful in dental care, in particular, useful for reducing or preventing demineralisation of teeth of a subject, in particular, for reducing or preventing further demineralisation of teeth of a subject. The dental care products comprises self-assembling peptides, in particular, comprise self-assembling peptides comprising the sequence of SEQ ID NO: 21, that are capable of undergoing self-assembly at a pH below 7.5, wherein the self-assembling peptides are essentially present in the dental care product in assembled form, and a pharmaceutically acceptable basis. The dental care product is an essentially solid product selected from the group consisting of chewing gum, soft chew, toffee, gelatin gum, chewy candy, chew toy, lozenge. Preferably, it is a chewy product. The dental care product is not abrasive.

Abstract: The invention is in the field of caries prevention and treatment, in particular minimally-invasive, or non-invasive dental decay treatment. It relates to a composition and a kit comprising a self-assembling peptide, such as the self-assembling peptide P11-4 or P11-8, and a dental agent, namely a dental sealant, e.g. a glass-ionomer cement-based sealant or a resin-based sealant, a fluoride varnish, a dental restorative material or a bonding agent. The invention further relates to a composition and kit comprising a self-assembling peptide and a dental agent for use in the treatment of a carious lesion, preferably a cavitated carious lesion. The self-assembling peptide prevents secondary caries after failure of the dental agent used in treatment of cavitated caries, especially in case of a failing interface between the restoration with the dental agent and the tooth. The composition and kit of the present invention may also be used for pulp capping.

Abstract: The present invention relates to the field of dental care, e.g., with toothpaste, tooth gel, mouth-wash, mouth spray or oral care foam. In particular, it provides an anti-inflammatory and senolytic dental care product with tooth whitening characteristics. The dental care product comprises calcium phosphate particles of a specific size, the self-assembling peptide P11-4 or oligopeptide 104 of SEQ ID NO: 1, an extract of a plant of the genus Rhododendron, preferably, an alpine rose or Alpenrose such as Rhododendron ferrugineum or Rhododendron hirsutum, and an extract of a plant of the genus Leontopodium, such as Leontopodium nivale, which is also called Edelweiss. The dental care product may further comprise an extract of a plant of the genus Eleutherococcus, such as Eleutherococcus senticosus, which is also designated Siberian ginseng or Acanthopanax senticosus.

Abstract: The present invention provides new dental care products comprising self-assembling peptides (SAP) that are capable of undergoing self-assembly at a certain pH for use in dental care, e.g. preventing and/or treating a tooth lesion such as a caries lesion, remineralising a tooth surface, increasing smoothness or shine or increasing hardness of a tooth surface. The dental care products may be administered following a simple protocol involving multiple steps, e.g., comprising tooth brushing with a sonic tooth-brush such as an ultrasonic toothbrush and/or use of an oral irrigator, thereby enabling non-targeted treatment of a plurality of teeth in a subject, independent of the diagnosis of active caries, i,e., not previously successfully treated caries. The invention also relates to said method as well as kits and devices suitable therefor.

Abstract: The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.

Abstract: The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.

Abstract: The present invention relates to the field of dental care, in particular, to a dental care product such as toothpaste (dentifrice), prophylactic paste, tooth powder, tooth polish, tooth gel, chewing gum, candy, lozenge, mouthwash, whitening strip, coated dental floss, coated toothbrush, paint-on gel, varnish, veneer, and tube, syringe or dental tray comprising a gel or paste, mouthwash, whitening strips and trays for whitening teeth, wherein the product comprises mineral particles such as crystals and a compound, preferably, a protein capable of forming a matrix which is a hydrogel, wherein the product comprises a fluorophore. The mineral particles may comprise, e.g., calcium phosphate, preferably, hydroxyapatite, preferably, in crystalline form. The protein matrix may comprise, e.g., a self-assembling peptide. The product also comprises a fluorophore, which may be a fluorescent amino acid residue of the protein matrix.

Abstract: The present invention provides new dental care products comprising self-assembling peptides that are capable of undergoing self-assembly at a certain pH for use in dental care, e.g. preventing and/or treating a tooth lesion such as a caries lesion, remineralising a tooth surface or increasing smoothness or shine, or for increasing hardness of a tooth surface. The present invention provides dental care products such as chewing gum, toffees or toothpaste, in which the peptides are present in monomeric form for a prolonged period after application into the oral cavity, thereby enabling non-targeted treatment of a plurality of teeth, independent of the diagnosis of an active lesion. Products of the invention are useful for animals and humans.

Abstract: The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.

Abstract: The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralizing a tooth lesion such as a subsurface caries lesion.

Abstract: The present invention relates to the field of dental care, in particular, to a dental care product such as toothpaste (dentifrice), prophylactic paste, tooth powder, tooth polish, tooth gel, chewing gum, candy, lozenge, mouthwash, whitening strip, coated dental floss, coated toothbrush, paint-on gel, varnish, veneer, and tube, syringe or dental tray comprising a gel or paste, mouthwash, whitening strips and trays for whitening teeth, wherein the product comprises mineral particles such as crystals and a compound, preferably, a protein capable of forming a matrix which is a hydrogel, wherein the product comprises a fluorophore. The mineral particles may comprise, e.g., calcium phosphate, preferably, hydroxyapatite, preferably, in crystalline form. The protein matrix may comprise, e.g., a self-assembling peptide. The product also comprises a fluorophore, which may be a fluorescent amino acid residue of the protein matrix.

Abstract: The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.

Abstract: An exhaust gas cleaning system includes a pyrolysation channel, a mixing channel downstream of the pyrolysation channel and a reaction channel downstream of the mixing channel. An atomizing nozzle is provided for injecting into the pyrolysation channel an atomized mixture of compressed air and a dilute urea solution. The compressed air and dilute urea solution contacts the exhaust gas stream in the pyrolysation channel wherein the urea decomposes into ammonium and carbon dioxide. Mixers are provided in the mixing channel for forming a homogeneous mixture of the ammonium and carbon dioxide with the exhaust gas. The reaction channel downstream of the mixing channel is provided with at least two catalysts for contacting the homogeneous mixture and removing effluents therefrom.

Abstract: In a process for cleaning the exhaust gases from combustion installations, a dilute urea solution prepared in a reagent tank (20) is introduced into the hot exhaust gas flow (30) of differing concentrations and is finely sprayed in the direction of the exhaust gas flow. After decomposition of the urea in a pyrolysation channel (14), the exhaust gas flow (30) is homogeneously mixed in-line by a mixer located in a mixing channel (16). In a subsequent in-line reaction channel (18), the reducible exhaust gas constituents are converted into non-toxic gases in at least one selective reduction catalyst which does not contain zeolite (36), then, dependent on the installation, the oxidizable exhaust gas components are converted into non-toxic gases without reagent in at least one oxidation catalyst (38) to produce a virtually complete reaction.