Abstract: Provided are recombinant adeno-associated virus (r.AAV) vectors comprising a transgene to express galactose-1-phosphate uridylyl transferase (GALT); virions comprising said vectors (r.AAV virions); methods of their production; methods of their use, including methods for treating galactosemia, GALT-deficiency, symptoms therefrom: and kits. These recombinant adeno-associated virus (rAAV) vectors comprise a method of treating galactosemia in a subject in need.

Abstract: The present disclosure is directed to a composite implant for the sustained release of a therapeutic agent from a hydrogel matrix. The hydrogel matrix may be a cross-linked bioerodible polyethylene glycol (PEG) hydrogel with a therapeutic complex dispersed within the cross-linked bioerodible PEG hydrogel. The therapeutic complex may include a therapeutic agent in association with mesoporous silica particles. The composite implant is configured to be delivered to or implanted into an eye of a subject or patient. The composite implant may be used treat ocular disease in a subject or patient. Ocular diseases may be selected from at least one of neovascular age related macular degeneration (AMD), diabetic macular edema, or macular edema following retinal vein occlusion.

Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Abstract: A re-bale feeder (10) comprising an open-topped box frame into which material is placed, a conveyor (12) within the box frame operative to urge the material in a longitudinal direction towards an exit end. Also disclosed is a bale former (30) comprising a rotating loading roller (31) with a plurality of radially extending members extending therefrom, a surround cage surrounding at least a forward side of the loading roller (31), the surround cage (33) having a plurality of opening therein to allow the radially extending members of the rotating loading roller (31) to extend therethrough during rotation of the loading roller (31), and a baling system to receive material loaded by the loading roller (31) and form the material into one or more bales and a bale assembly.

Abstract: Provided are recombinant adeno-associated virus (rAAV) vectors comprising a transgene to express galactose-1-phosphate uridylyl transferase (GALT); virions comprising said vectors (rAAV virions); methods of their production; methods of their use, including methods for treating galactosemia, GALT-deficiency, symptoms therefrom; and kits.

Abstract: Beamformers are formed (e.g., carved) from a stack of transparent sheets. A rear face of each sheet has a reflective coating. The reflectivities of the coatings vary monotonically with sheet position within the stack. The sheets are tilted relative to the intended direction of an input beam and then bonded to form the stack. The carving can include dicing the stack to yield stacklets, and polishing the stacklets to form beamformers. Each beamformer is thus a stack of beamsplitters, including a front beamsplitter in the form of a triangular or trapezoidal prism, and one or more beamsplitters in the form of rhomboid prisms. In use, a beamformer forms an output beam from an input beam. More specifically, the beamformer splits an input beam into plural output beam components that collectively constitute an output beam that differs in cross section from the input beam.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to improve offloading of malware scans. An example apparatus is to, based on a trigger to perform a scan of a volume of data, estimate a computational burden associated with performing the scan using the CPU, the volume of data representative of at least one of a file or an object. Additionally, the example apparatus is to determine whether the computational burden satisfies a threshold associated with offloading the scan to the GPU. The example apparatus is also to cause at least one of the CPU or the GPU to perform the scan based on whether the computational burden satisfies the threshold.

Abstract: An electromagnetic field detector including a vapor cell, an excitation system, and a frequency tuner is described. The vapor cell has a plurality of quantum particles therein. The excitation system excites the quantum particles to a first Rydberg state. The first Rydberg state has a transition to a second Rydberg state at a first frequency. The frequency tuner generates a tunable field in a portion of the vapor cell. The tunable field shifts the first Rydberg state and/or the second Rydberg state such that the transition to the second Rydberg state is at a second frequency different from the first frequency. The detection frequency range for the electromagnetic field detector is continuous and includes the first frequency and the second frequency.

Abstract: The present disclosure is directed to intracameral implants for treating and/or preventing corneal disorders, diseases, and/or conditions, such as corneal endothelial dystrophies. The intracameral implants can be configured to provide a sustained release of a therapeutic agent, such as a Rho kinase inhibitor, for a prolonged period of time. The intracameral implants can include a non-bioresorbable anchor or a bioresorbable matrix.

Abstract: A computer-implemented method is disclosed. The method includes: receiving, via a computing device in a locked state, input of a first PIN; determining that the first PIN is associated with a first cryptographic key that is stored in a memory; responsive to determining that the first PIN is associated with the first cryptographic key, retrieving, from the memory, an encrypted form of a first credential that is associated with the first cryptographic key; recovering the first credential from the encrypted form using the first cryptographic key; and causing the computing device to be unlocked using the recovered first credential.

Abstract: The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.

Abstract: A process for manufacturing custom optically active quantum-particle cells includes forming a pre-customization assembly and then, in response to receipt of specifications for quantum-particle cells, performing a customization subprocess on the pre-customization assembly to yield custom quantum-particle cells, e.g., vapor cells, vacuum cells, micro-channel cells containing alkali metal or alkaline-earth metal ions or neutral atoms. The customization can include forming metasurface structures on cell walls, e.g., to serve as anti-reflection coatings, lenses, etc., and introducing quantum particles (e.g., alkali metal atoms). A cover can be bonded to hermetically seal the assembly, which can then be diced to yield plural separated custom optically active quantum-particle cells.

Abstract: An ultra-high-vacuum (UHV) cell includes an integrated guide stack (IGS) as part of a boundary between an internal vacuum and an external ambient. The IGS is formed by bonding together plural integrated guide components (IGCs). Each IGC includes (prior to the bonding) electrical and/or electro-magnetic (EM) guides defined within a bulk material such as glass or silicon. The electrical guides can be, for example, conductive paths or vias, while the EM guides can include microwave or other RF guides, optical fibers and/or paths along which an index of refraction has been modified along an desired optical path. EM and electrical connections between IGCs can be formed after the IGCs are bonded together to form the IGS. Use of an IGS as a vacuum boundary can provide substantial functionality for manipulating and interrogating quantum particles; the functionality can include, for example, the ability to regulate fields within the UHV cell.

Abstract: A motorized control system for a medical device may include a control assembly including a first body with a cradle assembly and a second body moveably coupled to the first body. The cradle assembly may be configured to removably couple to the medical device. The second body may include a gear assembly, a first motor configured to drive a first gear of the gear assembly, and a second motor configured to drive a second gear of the gear assembly. The control assembly may be configured to transition between an open configuration and a closed configuration. The gear assembly may be configured to receive a plurality of knobs of the medical device in the closed configuration. The first motor may be configured to drive the first gear to rotate a first knob. The second motor may be configured to drive the second gear to rotate a second knob.

Abstract: A medical device includes a handle including a stationary body, a first movable body, and a second movable body; a control member coupled to the second movable body; an intermediate sheath coupled to the first movable body; an external sheath coupled to the stationary body; and an end effector. The end effector includes a first loop and a second loop. The first loop includes a first arm and a second arm, and the first arm is coupled to the intermediate sheath. The second arm is coupled to the control member, and the second arm includes a first plurality of teeth. The second loop includes a third arm and a fourth arm. The third arm is coupled to the intermediate sheath, and the fourth arm is coupled to the control member. The fourth arm includes a second plurality of teeth.

Abstract: A vacuum cell provides for electric field control within an ultra-high vacuum (UHV) for cold-neutral-atom quantum computing and other quantum applications. Electrode assemblies extend through vacuum cell walls. Prior to cell assembly, contacts are bonded to respective locations on the ambient-facing surfaces of the walls. Trenches are formed in the vacuum-facing surfaces of walls and via holes are formed, extending from trenches through the wall and into the contacts. Plating conductive material into the trenches and via holes forms the electrodes and vias. The electrodes are contained by the trenches and do not extend beyond the trenches so as to avoid interfering with the bonding of components to the vacuum-facing surfaces of the walls. The vias extend into the contacts to ensure good electrical contact. An electric-field controller applies electric potentials to the electrodes (via the contacts) to control electric fields within the vacuum.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: A compact C-shaped scanner employs at least two sensors and has a mechanism to standardize or calibrate the sensors. The upper and lower elongated beams of the C-frame include a mid-beam sensor and an outer beam sensor. The scanner can monitor the entire width of a continuous sheet by advancing the scanner back and forth along a scanning distance that is only about half that of the sheet width thereby minimizing the required offsheet distance by an amount approaching half the width of the sheet being monitored. Standardization tiles consisting of references materials that are positioned laterally from the edges of the moving sheet allow for calibration of the sensors which operate either in the transmissive or reflective mode. Selected sheet properties or characteristics of the sheet material can be measured. The two sensors can operate in the transmissive or four sensors can operate in the reflective mode.

Abstract: A flatbed (10) is provided to which left and right-side skirts with wheel wells (14) may be coupled. Sets of skirts are provided with the wheel wells (14) in each set located in a respective predetermined position on the skirts to match a respective truck axle position, the respective predetermined position being different from set to set.

Abstract: In an aspect, a system for monitoring a battery system in-flight. The system includes at least a battery pack and a pack monitoring unit (PMU) communicatively connected with a battery pack. The battery pack includes a plurality of battery packs. The PMU may include at least a sensor and a controller. At least a sensor is configured to detect battery datum. A controller is communicatively connected with at least a sensor. A controller is configured to receive battery datum, detect a significant event as a function of battery datum, and transmit the significant event to a remote device.