Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 ?g/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.

Abstract: A completion string includes at least one isolation packer positioned between well zones of a plurality of well zones, and a sand control assembly and a circulating assembly each disposed uphole of a washdown shoe in the bottom-most well zone. A top well zone includes a return valve assembly, a production packer, and a second circulating assembly and a second sand control assembly downhole of the production packer. The completion string also includes an outer string spanning from the bottom-most well zone to the top well zone, and an inner production string concentrically arranged within the outer string, creating an inner-annulus between the outer string and inner production string. The inner-annulus is continuous from the washdown shoe to the return valve assembly, and the inner production string includes a production valve disposed between the sand control assembly and the circulating assembly in each of the bottom-most and top well zones.

Abstract: A technique facilitates performance of a gravel packing operation and desired zonal isolation. An apparatus, e.g. a sliding sleeve shunt tube isolation valve, may be deployed downhole and configured to facilitate a gravel packing operation and zonal isolation. By way of example, the apparatus contains a conduit which in an open position allows the flow of gravel pack slurry and in a closed position creates a barrier. In the closed position, upper and lower portions of the conduit are isolated from one another. When the apparatus is coupled with a packer and sand screens, the apparatus serves to create complete zonal isolation in, for example, an open hole alternate path system.

Abstract: A downhole tool includes a base pipe having an opening formed radially-therethrough. The downhole tool also includes a valve positioned at least partially within the opening. The valve includes a dissolvable insert and an impediment. The dissolvable insert prevents the impediment from contacting a seat of the valve such that the valve permits fluid flow in both axial directions through the valve. After the dissolvable insert dissolves, the impediment contacts the seat such that the valve permits fluid flow in one axial direction through the valve but prevents fluid flow in the opposing axial direction through the valve.

Abstract: A downhole tool includes a sand control device, a tubular member coupled to and positioned below the sand control device, a shifting device coupled to the tubular member, and a load-monitoring sensor coupled to the tubular member and positioned between the sand control device and the shifting device.

Abstract: A technique facilitates performance of a gravel packing operation and desired zonal isolation. An apparatus, e.g. a sliding sleeve shunt tube isolation valve, may be deployed downhole and configured to facilitate a gravel packing operation and zonal isolation. By way of example, the apparatus contains a conduit which in an open position allows the flow of gravel pack slurry and in a closed position creates a barrier. In the closed position, upper and lower portions of the conduit are isolated from one another. When the apparatus is coupled with a packer and sand screens, the apparatus serves to create complete zonal isolation in, for example, an open hole alternate path system.

Abstract: An internal completion string is anchored within a closed casing valve of a production liner in a wellbore. The internal completion string comprises a packer and a shifting tool. The production liner comprises a casing valve having a port and a moveable member. The annulus defined between the production liner and the internal completion string is sealed, and the shifting tool is remotely operated to move the moveable member away from the port, thereby opening the casing valve.

Abstract: A downhole tool includes a base pipe having an opening formed radially-therethrough. The downhole tool also includes a valve positioned at least partially within the opening. The valve includes a dissolvable insert and an impediment. The dissolvable insert prevents the impediment from contacting a seat of the valve such that the valve permits fluid flow in both axial directions through the valve.

Abstract: A downhole tool includes a sand control device, a tubular member coupled to and positioned below the sand control device, a shifting device coupled to the tubular member, and a load-monitoring sensor coupled to the tubular member and positioned between the sand control device and the shifting device.

Abstract: Embodiments of the invention include compositions and methods related to replicative oncolytic rhabdoviruses pseudotyped with an arenavirus glycoprotein and their use as anti-cancer therapeutics particularly in combination with complement inhibitors.

Abstract: A downhole tool includes a deactivation member, a latching member, a release member, and a biasing member. The deactivation member includes an outer protrusion. The latching member is positioned radially-outward from the deactivation member. The latching member includes an inner protrusion and an outer protrusion. The release member includes a sleeve extending axially toward the outer protrusion of the latching member. The biasing member exerts an axial force on the latching member.

Abstract: A downhole tool includes a shifting device and a load-monitoring sensor positioned above the shifting device. A distance between the shifting device and the load-monitoring sensor is less than or equal to about 10 m.

Abstract: A technique facilitates formation of a gravel pack in a wellbore. Gravel slurry is delivered downhole to a desired gravel packing zone located along an annulus surrounding a gravel packing completion. Dehydration of the gravel pack is facilitated by providing a return flow path for a carrier fluid along drainage layers of adjacent screen assemblies. The drainage layers of adjacent screen assemblies are coupled by drainage layer shunt tubes which bypass corresponding couplings between the adjacent screen assemblies. In some applications, the drainage layer shunt tubes facilitate delivery of the returning carrier fluid to a sliding sleeve assembly.

Abstract: A downhole tool includes a shifting device and a load-monitoring sensor positioned above the shifting device. A distance between the shifting device and the load-monitoring sensor is less than or equal to about 10 m.

Abstract: A downhole tool includes a deactivation member, a latching member, a release member, and a biasing member. The deactivation member includes an outer protrusion. The latching member is positioned radially-outward from the deactivation member. The latching member includes an inner protrusion and an outer protrusion. The release member includes a sleeve extending axially toward the outer protrusion of the latching member. The biasing member exerts an axial force on the latching member.

Abstract: A technique facilitates formation of a gravel pack in a wellbore. Gravel slurry is delivered downhole to a desired gravel packing zone located along an annulus surrounding a gravel packing completion. Dehydration of the gravel pack is facilitated by providing a return flow path for a carrier fluid along drainage layers of adjacent screen assemblies. The drainage layers of adjacent screen assemblies are coupled by drainage layer shunt tubes which bypass corresponding couplings between the adjacent screen assemblies. In some applications, the drainage layer shunt tubes facilitate delivery of the returning carrier fluid to a sliding sleeve assembly.

Abstract: An internal completion string is anchored within a closed casing valve of a production liner in a wellbore. The internal completion string comprises a packer and a shifting tool. The production liner comprises a casing valve having a port and a moveable member. The annulus defined between the production liner and the internal completion string is sealed, and the shifting tool is remotely operated to move the moveable member away from the port, thereby opening the casing valve.

Abstract: An internal completion string is anchored within a closed casing valve of a production liner in a wellbore. The internal completion string comprises a packer and a shifting tool. The production liner comprises a casing valve having a port and a moveable member. The annulus defined between the production liner and the internal completion string is sealed, and the shifting tool is remotely operated to move the moveable member away from the port, thereby opening the casing valve.

Abstract: A method comprising moving a shifting tool in a first direction through a moveable member positioned in a casing of a wellbore, including moving the shifting tool through a shifting tool interface member (STIM) adjacent the moveable member, until the shifting tool is positioned past the moveable member and the STIM. The shifting tool is then moved in a second direction substantially opposite the first direction until the shifting tool and the STIM engage. The shifting tool is then further moved in the second direction, thereby moving the STIM and the moveable member in the second direction, until the STIM substantially simultaneously (1) engages the casing and (2) disengages the shifting tool.

Abstract: Systems and methods for fracturing multiple zones in a wellbore. A first port in a first valve assembly can be opened with a shifting tool. A fluid flows through the first port to fracture a first zone, and the first port can be closed with the shifting tool after the first zone has been fractured. A second port can be opened in a second valve assembly with the shifting tool after the first port has been closed, wherein the second valve assembly is positioned below the first valve assembly. The fluid can flow through the second port to fracture a second zone, and the second port can be closed with the shifting tool after the second zone has been fractured.