Abstract: The invention provides an antigenic peptide comprising an epitope for use in the prevention and/or treatment of an infection by C. difficile, e.g. for use as a vaccine in the prevention and/or treatment of an infection by C. difficile, and protective antibodies directed against the epitope.

Abstract: The invention provides a fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

Abstract: An e-commerce system is provided that tracks purchase transaction across multiple client devices. The e-commerce system stores hop information describing when a customer is exposed to a product of a vendor through an affiliate who advertises the vendor's products. The e-commerce system determines from the stored hop information which affiliate or affiliates to compensate for the sale of a product. This allows the e-commerce system to determine, after the sale, whether additional affiliates need to be compensated for the sale of the product based on the hop information.

Abstract: An e-commerce system is provided that tracks purchase transaction across multiple client devices. The e-commerce system stores hop information describing when a customer is exposed to a product of a vendor through an affiliate who advertises the vendor's products. The e-commerce system determines from the stored hop information which affiliate or affiliates to compensate for the sale of a product. This allows the e-commerce system to determine, after the sale, whether additional affiliates need to be compensated for the sale of the product based on the hop information.

Abstract: The invention provides an antigen-binding protein that specifically binds to a conformational epitope formed by domain III & IV of human epidermal growth factor receptor 3 (HER3) and antigen-binding proteins which compete therewith for binding, as well as fusion protein or conjugate comprising these. The invention also provides nucleic acid molecule comprising a sequence encoding said antigen binding proteins, vectors comprising the nucleic acid, and cells and pharmaceuticals comprising the antigen binding protein, the fusion protein, the nucleic acid, or the vector. The invention also provides the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical for use as a medicament.

Abstract: The present invention relates to combinations of tick-derived antigens for use as a tick vaccine.

Abstract: The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.

Abstract: An e-commerce system is provided that tracks purchase transaction across multiple client devices. The e-commerce system stores hop information describing when a customer is exposed to a product of a vendor through an affiliate who advertises the vendor's products. The e-commerce system determines from the stored hop information which affiliate or affiliates to compensate for the sale of a product. This allows the e-commerce system to determine, after the sale, whether additional affiliates need to be compensated for the sale of the product based on the hop information.

Abstract: The invention provides a fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

Abstract: An e-commerce system is provided that tracks purchase transaction across multiple client devices. The e-commerce system stores hop information describing when a customer is exposed to a product of a vendor through an affiliate who advertises the vendor's products. The e-commerce system determines from the stored hop information which affiliate or affiliates to compensate for the sale of a product. This allows the e-commerce system to determine, after the sale, whether additional affiliates need to be compensated for the sale of the product based on the hop information.

Abstract: Formation and/or generation of silicate aggregates having a graduated linear spectrum of physical and/or chemical properties are disclosed. For example, a given foamed silicate aggregate may include a graduated linear spectrum of open-cell to closed-cell structures, porous to solid and/or anti-porous structures, and/or both. The foamed silicate aggregate may also include one portion that is heavier than another portion. The aggregate may be constructed of a material that sinks such that the heavier portion contacts a bottom of a body of water, or the aggregate may be constructed of a material that floats such that the heavier portion is below the surface of the water. The aggregate may additionally be stratified and/or may include suspended beads of material.

Abstract: Systems and methods for generation of porous silicate aggregates are disclosed. For example, the manufacturing systems may include a conveyor element, multiple hoppers positioned over a first section of the conveyor element, one or more derricks and/or holding elements to move and/or hold the hoppers, a kiln positioned with respect to a second portion of the conveyor element, and/or computing components to allow for control of the components of the system. The system may produce single-layer products in a continuous fashion, multi-layered products having multiple physical and/or chemical properties, and/or more than one product at a time.

Abstract: The present invention provides an antigen-binding protein that specifically binds to a conformational epitope formed by domain III & IV of human epidermal growth factor receptor 3 (HER3) and antigen-binding proteins which compete therewith for binding, as well as fusion protein or conjugate comprising these. The present invention also provides nucleic acid molecule comprising a sequence encoding said antigen binding proteins, vectors comprising the nucleic acid, and cells and pharmaceuticals comprising the antigen binding protein, the fusion protein, the nucleic acid, or the vector. The present invention also provides the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical for use as a medicament.

Abstract: An e-commerce system is provided that tracks purchase transaction across multiple client devices. The e-commerce system stores hop information describing when a customer is exposed to a product of a vendor through an affiliate who advertises the vendor's products. The e-commerce system determines from the stored hop information which affiliate or affiliates to compensate for the sale of a product. This allows the e-commerce system to determine, after the sale, whether additional affiliates need to be compensated for the sale of the product based on the hop information.

Abstract: Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the antibodies, e.g. for use in the analytical processes and analysis, to pharmaceutical compositions comprising the antibodies, and to use of the antibodies in the manufacture of pharmaceutical compositions for tumor treatment or for diagnostic purposes.

Abstract: Embodiments are directed towards managing designations of a plurality of files across multiple clusters. Files may be designated as primary files or secondary files. Primary files at one cluster may be asynchronously replicated at another cluster as secondary files. Secondary files may be synchronously validated with remote primary files based on local file access requests. If a write request for a local secondary file is provided, then the local file may be designated as the primary file and the remote file may be designated as the secondary file. Local access may then be provided to the local primary file. If a read request for a local secondary file is provide, then local access may be provided to the local secondary file without changing file designations. In some embodiments, file designations may be preemptively changed based on a file change designation schedule for clusters at different geographic locations.

Abstract: This invention describes a system for utilizing dimensionalized archetypical or proxy representations of a person, place, thing, concept or construct and generally, a method for utilizing such representations for the purposes of information retrieval, knowledge management, and machine learning whereby the representations contribute to enhanced speed, contextual acuity, and overall value of the information stored within the system, as well as the easy utilization of the archetypical or proxy representations by such means or methods as weighted sorts, support vector machines, probabilistic filters, or other means whereby one or more of the dimensionalized tags or features represented by the affinitomic elements are utilized to make a selection.

Abstract: Embodiments are directed towards cloning files in a distributed file system. In response to a request to create file clones, a file cloning application can be employed to generate file clones based on a source file. The file cloning application can generate a new inode for each new file clone and at least one new shadow store. Data blocks from the source file can be transferred to the shadow store. The transferred data blocks can be replaced with reference blocks that point to the data blocks transferred to the shadow store. Likewise, additional reference blocks pointing to data blocks in the shadow store can be generated for the new file clone inodes. Further, the shadow store can maintain reference counters that track the number of reference blocks pointing to each shadow store block. Also, file clones can be generated based on a point-in-time snapshot of the source file.

Abstract: This invention describes a system and method for creating analyzing, and comparing proxy representations of persons, places, things, concepts, and constructs for purposes of knowledge management, knowledge discovery, and information retrieval. To facilitate the system an archetype is created that contains a list of words and or phrase descriptors of the object represented by the proxy, an additional list of draws to the proxy consisting of words or phrases describing objects that have a positive affinity with the object being described by the proxy, and an additional list of distances to the proxy consisting of words or phrases describing objects that have a negative affinity with the object being described by the proxy. Both draws and distances may be assigned an amplitude, such that the feature space described by the archetype becomes dimensionalized.

Abstract: Various embodiments are directed towards enabling data writes utilizing a node cache and a logstore stored on a stable storage device. A client device may send data to a node for writing to a parent file. The node may cache the received data prior to writing the data to the parent file. Caching the received data may comprise adding the received data to a node cache and to a logstore. In one embodiment, the node cache may include a coalescer that combines data from a plurality of data writes from the client device to the node prior to writing to the parent file. In some embodiments, the logstore may be mirrored logstore on one or more stable storage devices. The parent file may periodically be updated from the node cache data. After the parent file is updated, the node cache data and the logstore data may be purged.