Abstract: Methodologies and systems to compare images with different levels of contrast are provided. Contrast is normalized between the images with different contrast levels and brightness is set. When normalizing contrast a derivative of gray level is determined for a first digital image having a first contrast level, and a derivative of gray level is determined for a second digital image having a second contrast level that is greater than the first contrast level. A ratio of the derivative of gray level for the first digital image to the derivative of gray level for the second digital image is determined, and the derivative of gray level for the first digital image is equalized with the derivative of gray level for the second digital image. Brightness of at least one image may be set automatically, such as by calculating an average pixel value excluding background and text, or manually.

Abstract: The present invention provides a method of delivering a treatment to the central nervous system, including the steps of administering a therapeutic intramuscularly into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves, and transporting the therapeutic peripherally through nerves into the CNS and to the site of treatment. The present invention provides a method of treating a neural disorder or a part of the body by administering an effective amount of a compound affecting neural cells into muscles innervated by cranial and/or spinal nerves, and affecting neural cells. The present invention also provides a method of treating a spinal cord injury by administering an effective amount of a compound affecting neural cells into musculature directly innervated by the spinal cord, and affecting neural cells.

Abstract: In accordance with certain disclosed embodiments of the present invention, there is provided an assay test device for determining whether a fluid under test contains a certain substance, wherein the device includes a test strip disposed at least partially within a housing for receiving the fluid under test. A sensor mounted on the housing detects the certain substance in the fluid under test received on the test strip to generate an electrical signal indicative of the amount of the substance detected. A processor responds to the signal for determining whether or not the fluid under test contains a predetermined quantity of the certain substance to generate an electric output signal. A display mounted on the housing responds to the output signal to indicate the presence or absence of a predetermined quantity of the certain substance contained within the fluid under test.

Abstract: In accordance with certain disclosed embodiments of the present invention, there is provided a method of analyzing assay test results for determining whether a fluid under test contains a certain substance. The disclosed method includes detecting the certain substance in the fluid under test received on a test strip, and generating an electrical signal indicative of the amount of the substance detected. The disclosed method further includes responding to the signal, and determining whether or not the fluid under test contains a predetermined quantity of the certain substance to generate an electric output signal. The method disclosed also includes responding to the output signal to indicate the presence or absence of a predetermined quantity of the certain substance contained within the fluid under test. The disclosed method includes delaying in the detecting until after a predetermined time delay interval, and storing the detected information at the completion of the time delay interval.

Abstract: The present invention relates to systems, methods and apparatus for improving the yield for separating components of fluids, for example biological or sensitive fluids such as blood, and improving the component yield, for example, from donated whole blood by separating its components by density in a centrifuge bowl with a multi-axial lumen. The apparatus, system, and method eliminate the need to batch-type separate blood and can reduce the time needed to treat patients suffering from T-cell or white blood cell mediated diseases or conditions to less than 70 minutes. In one aspect, the invention is a centrifuge bowl (10) comprising an outer housing (100); a core (200); a lower plate (300); a lumen (400); a first bowl channel (420) within said lumen (400) for inflowing said fluid (800); a second bowl channel (410) for removing a first separated fluid component (810); and a third bowl channel (740) for removing a second separated fluid component (820).

Abstract: A collection device for a testing system includes a central volume and a trough, adjacent the central volume. The trough is configured with a pour spout such that, as fluid is poured from the collection device, a controlled volume remains in the trough. The trough is configured to receive a portion of a test kit and to apply the controlled volume of the sample to test strips within the test kit. The trough can also include apertures in the wall between the trough and the central volume which allow excess sample to flow back into the cup when the cup is placed upright after pouring and when the test kit is inserted into the trough.

Abstract: A method of detecting Parkinson's disease through MRI of substantial nigra pars compacts (SNc) tissue. The method involves obtaining a gray matter suppressed (GMS) MRI signal from the SNc tissue, obtaining a white matter suppressed (WMS) MRI signal of the SNc tissue, and combining information from the GMS and WMS MRI signals to produce resultant signals indicative of Parkinson's disease. A similar method can be used to detect Progressive Supranuclear Palsy. A method of distinguishing between the two diseases involves obtaining at least two starting MRI images of SNc tissue using different MRI parameters, and combining the starting images to compute resultant signals differentiating between the two forms of parkinsonism.

Abstract: A LAN/WAN network topology and design methodology using Internet Protocol (IP) subnet topology, ATM WAN configuration, equipment placement, and device configuration to provide partitioning of a call processing application across multiple sites. The partitioning reduces latency for mission critical messages, while providing for necessary provisioning traffic needs. Further, the overall topology provides the redundancy and resiliency necessary for mission critical call processing application, utilizing the IP subnets, ATM permanent virtual circuits, network device configuration, and server segregation to achieve Quality of Service (QoS).

Abstract: Parkinson's disease can be treated with an at least one cholinesterase inhibitor. The cholinesterase inhibitor has been found to alleviate both any symptoms of dementia as well as to reduce rigidity and improve motor function.