Patents by Inventor Michael J. A. Walker

Michael J. A. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drug combination of PDE3/PDE4 inhibitor and muscarinic receptor antagonist
    Patent number: 10471063
    Abstract: The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 12, 2019
    Assignee: Verona Pharma PLC
    Inventors: Michael J. A. Walker, Mario Cazzola, Luigino Calzetta
  • Drug combination
    Patent number: 9717732
    Abstract: The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a ?2-adrenergic receptor agonist.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: August 1, 2017
    Assignee: VERONA PHARMA PLC
    Inventors: Michael J. A. Walker, Mario Cazzola, Luigino Calzetta
  • Drug combination of PDE3/PDE4 inhibitor and muscarinic receptor antagonist
    Patent number: 9700558
    Abstract: The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 11, 2017
    Assignee: VERONA PHARMA PLC
    Inventors: Michael J. A. Walker, Mario Cazzola, Luigino Calzetta
  • Crystalline form of pyrimido[6,1-A] isoquinolin-4-one compound
    Patent number: 9062047
    Abstract: The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: June 23, 2015
    Assignee: Verona Pharma plc
    Inventors: Michael J. A. Walker, Bertrand M. C. Plouvier, Julian S. Northen, Philippe Fernandes
  • Ion channel modulating compounds and uses thereof
    Patent number: 8008342
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: August 30, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander R. Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7875611
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: January 25, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
    Patent number: 7687536
    Abstract: Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: March 30, 2010
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Cindy J. Longley, Michael J. A. Walker, Richard A. Wall
  • ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20100029639
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Application
    Filed: April 15, 2009
    Publication date: February 4, 2010
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7534790
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: May 19, 2009
    Assignee: Cardiome Pharma Corp.
    Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7524879
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: April 28, 2009
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander R. Zolotoy
  • Aminocyclohexyl ether compounds and uses thereof
    Patent number: 7345087
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: March 18, 2008
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7259184
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: August 21, 2007
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N Beatch, Bertrand M C Plouvier, Tao Sheng, Michael J A Walker, Richard A Wall, Sandro L Yong, Jeff Jiqun Zhu, Alexander B Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7101877
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: September 5, 2006
    Assignee: Cardiome Pharma Corp.
    Inventors: Allen I Bain, Gregory N Beatch, Cindy J Longley, Bertrand M C Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L Yong, Jeff Jiqun Zhu, Alexander B Zolotoy
  • Ion channel modulating compounds and uses thereof
    Patent number: 7057053
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: June 6, 2006
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
    Patent number: 7053087
    Abstract: Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia. n=1–4; R1, R2, R3, R4, R5, R13, X and A are as in claim (1).
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: May 30, 2006
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Cindy J. Longley, Michael J. A. Walker, Richard A. Wall
  • Cycloalkyl amine compounds and uses thereof
    Patent number: 6979685
    Abstract: Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: December 27, 2005
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Michael J. A. Walker, Richard A. Wall, Alexander B. Zolotoy
  • Aminocyclohexylesters and uses thereof
    Patent number: 6174879
    Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: January 16, 2001
    Assignee: University of British Columbia
    Inventors: Bernard A. MacLeod, Michael J. A. Walker, Richard A. Wall
  • Aminocyclohexylesters and uses thereof
    Patent number: 5885984
    Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: March 23, 1999
    Assignee: University of British Columbia
    Inventors: Bernard A. MacLeod, Michael J. A. Walker, Richard A. Wall
  • Aminocyclohexylesters and uses thereof
    Patent number: 5637583
    Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: June 10, 1997
    Assignee: University of British Columbia
    Inventors: Bernard A. MacLeod, Michael J. A. Walker, Richard A. Wall
  • Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
    Patent number: 5506257
    Abstract: The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and instructions for the use of the compounds for the treatment of arrhythmia or for the inducement of local anaesthesia.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: April 9, 1996
    Assignee: University of British Columbia
    Inventors: Bernard A. MacLeod, Michael J. A. Walker, Richard A. Wall