Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

Abstract: Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia. n=1–4; R1, R2, R3, R4, R5, R13, X and A are as in claim (1).

Abstract: Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.

Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

Abstract: The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and instructions for the use of the compounds for the treatment of arrhythmia or for the inducement of local anaesthesia.

Abstract: A flexible isolator bag used to isolate a controlled therapeutic gas atmosphere about a human limb for the management and treatment of wounds and lesions, or an amputation, has a discharge port and a flexible manifold section providing an intake manifold which has an infeed port and inlet openings to the interior of the bag. A self-sealing zipper extends along part of the length of the bag. The bag is secured to the patient by adhesive tape applied to the rim of the open end of the bag. This rim is shaped to prevent a tourniquet effect.

Abstract: Acid water containing toxic levels (>0.1 ppm) of aluminum is treated to dissolve therein both silicate ions in an amount to create a solution containing at least 40, preferably at least 100, micromoles per liter of silicon and a silicon:aluminum ratio (based on metals) of at least about 6:1 and preferably 10:1 in the water to form a non-toxic complex with aluminum and alkali or alkali metal ions to increase the pH of the water. The preferred treatment agent is a hydraulic calcium silicate, in the form of cement clinker, optionally silicate-enriched with a soluble silicate.

Abstract: A bleach formulation comprising an aqueous solution/suspension of sodium perborate tetrahydrate (preferably "fines") and a thickening agent and optionally and preferably one or more other ingredients of conventional detergent compositions, notably an aqueous sodium silicate solution.

Abstract: An electric circuit arrangement for use in energising a flash tube (3) to provide a series of pairs of flashes, each pair consisting of a main flash and a rapidly following second flash, includes first and second capacitors (C9, C10) which are controlled to effect discharge of first only the first capacitor (C9) and then both the first and second capacitors (C9, C10) across the flash tube (3), cyclically, to provide the two flashes of each pair, in series. By varying the relative values of the first and second capacitors (C9, C10) the time interval between the flashes of each pair can be varied. All flashes produced can have the same peak intensity while the flashes in each pair can have different energy contents.

Abstract: A motion detector system includes an ultrasonic transmitter, receiver and phase detector which produces as output signals of frequency related to the speed of movement of any moving object in a zone being monitored. The output of the phase detector is fed to two separate bandpass filters having different pass-bands characteristic of the frequencies generated by a human being moving in the zone being monitored. A warning is sounded only when signals have been present in both bands for more than a predetermined period.

Abstract: A circuit for recognizing cyclically occurring pulse sequences includes a counter controlled by a D-type flip-flop circuit to start counting the pulses in the pulse sequence when a specific pulse event occurs. The output of the counter is compared by a comparator with a preset number to provide an output via a gate if the specific pulse event occurs when the number of pulses counted by the counter is equal to the preset number. If the count rises above the preset number the comparator resets the flip-flop and no output is produced by the gate.

Abstract: A missing pulse detector includes a plurality of signal accumulation capacitors which are discharged periodically and then charged via resistor during the periods between pulses in the input pulse train at an input terminal. The voltage signals on the capacitors are compared by comparators the resistors being of values such that the comparator outputs are high (at the comparison time) unless a pulse is missed.

Abstract: An apparatus for testing an i.c.e. ignition system of the kind including an ignition coil and a semi-conductor switch means controlling current interruption in the coil primary, includes a voltage comparator connected to compare the voltage across the switch means with a predetermined voltage. The comparator output starts a monostable timer circuit, the output of which is gated with the output of the comparator to produce an output signal only if the voltage across the switch means falls below the predetermined voltage within a predetermined time duration.

Abstract: A test apparatus for testing internal combustion engine spark ignition systems includes input terminals for connection across the electronic switch of the ignition system under test. A plurality of comparators are connected to compare the voltage across the input terminals with different reference levels and the comparator outputs are connected via peak storage circuits to a logic circuit which drives indicators indicating various fault conditions.

Abstract: A test apparatus for testing electronic ignition systems includes a circuit for detecting the interruption of ignition coil primary current and triggering a 100 .mu.S monostable. A coil current detector detects when coil current flow is recommenced and the signals from this detector and the monostable are combined via a gate to indicate satisfactory operation if the detector detects current re-commencement within 100 .mu.S of the previous current interruption.