Patents by Inventor Michael J. Abrams

Michael J. Abrams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220016127
    Abstract: Disclosed herein include methods, compositions, and kits suitable for use in inducing reparative regeneration and/or appendage regeneration. In some embodiments, the method comprises administering to a subject in need thereof a therapeutically effective amount of one or more amino acids and a therapeutically effective amount of one or more sugars, and thereby inducing reparative regeneration or appendage regeneration in the subject. There are provided, in some embodiments, regenerative agents suitable for use in the methods provided herein. Regenerative agents can stimulate mTOR signaling and/or insulin signaling. Regenerative agents can include one or more amino acids, insulin, and/or one or more sugars.
    Type: Application
    Filed: June 23, 2021
    Publication date: January 20, 2022
    Inventors: Lea Goentoro, Michael J. Abrams, Fayth Tan, Martin Heithe, Ty Basinger
  • Patent number: 11191849
    Abstract: The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 7, 2021
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Abrams, James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Stephen P. Reid, Edward D. Yaworski
  • Publication number: 20150246019
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: October 3, 2014
    Publication date: September 3, 2015
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor Macfarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Publication number: 20110129448
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 2, 2011
    Applicant: Genzyme Corporation
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Patent number: 7935692
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 3, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Patent number: 7897590
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 1, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Patent number: 7192609
    Abstract: Conditions such as kidney stones, which are characterized by undesired absorption of oxalate from the intestinal tract are conveniently treated using nontoxic salts of rare earth metal ions.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: March 20, 2007
    Assignee: Shire International Licensing B.V.
    Inventors: Michael J. Abrams, Gary J. Bridger, Simon P. Fricker, Stefan R. Idzan
  • Patent number: 7169750
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z? ??(1) or pharmaceutically acceptable salt thereof wherein Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1–20 atoms, Z? is of the formula —Ar(Y)j; wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0–3; and “linker” represents a bond, alkylene (1–6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: January 30, 2007
    Assignee: Anormed, Inc.
    Inventors: Gary Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald T. MacFarland, Gary B. Calandra
  • Patent number: 6987102
    Abstract: Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and/or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 17, 2006
    Assignee: Anormed, Inc.
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Patent number: 6670354
    Abstract: Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: December 30, 2003
    Assignee: AnorMed, Inc.
    Inventors: Ronald Trevor MacFarland, Andrew W. Millar, Gary Bridger, Michael J. Abrams, Geoffrey W. Henson
  • Publication number: 20030130250
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: July 30, 2002
    Publication date: July 10, 2003
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra
  • Publication number: 20020193363
    Abstract: The present invention relates to modulating inflammation, or improving hemodynamic function, associated with trauma, such as that caused by surgery, through the administration of metal complexes, such as ruthenium nitric oxide scavengers. Further, the present invention relates to modulating matrix metalloproteinase activity also by administering such metal complexes. Modulation of the trauma or the metalloproteinase activity reduces tissue damage or causes a protective effect against organ damage.
    Type: Application
    Filed: December 7, 2001
    Publication date: December 19, 2002
    Inventors: Gary J. Bridger, Simon P. Fricker, Michael J. Abrams, Irvin Mayers
  • Publication number: 20020155168
    Abstract: Conditions such as kidney stones, which are characterized by undesired absorption of oxalate from the intestinal tract are conveniently treated using nontoxic salts of rare earth metal ions.
    Type: Application
    Filed: April 22, 2002
    Publication date: October 24, 2002
    Inventors: Michael J. Abrams, Gary J. Bridger, Simon P. Fricker, Stefan R. Idzan
  • Patent number: 6417182
    Abstract: New pharmaceutical compositions and pharmaceutical compositions comprising metal complexes have activity against diseases caused by or related to overproduction or localized high concentration of nitric oxide in the body.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 9, 2002
    Assignee: AnorMED Inc.
    Inventors: Michael J Abrams, Simon P Fricker, Barry A Murrer, Owen J Vaughan
  • Publication number: 20020058653
    Abstract: Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed.
    Type: Application
    Filed: January 4, 2002
    Publication date: May 16, 2002
    Inventors: Ronald Trevor MacFarland, Andrew W. Millar, Gary Bridger, Michael J. Abrams, Geoffrey W. Henson
  • Publication number: 20020049190
    Abstract: A compound of the formula
    Type: Application
    Filed: March 17, 2000
    Publication date: April 25, 2002
    Inventors: Gary J. Bridger, Beth R. Cameron, Simon P. Fricker, Michael J. Abrams, Renato Skerlj, Ian Baird
  • Publication number: 20020045611
    Abstract: New pharmaceutical compositions and pharmaceutical compositions comprising metal complexes have activity against diseases caused by or related to overproduction or localized high concentration of nitric oxide in the body.
    Type: Application
    Filed: March 9, 2001
    Publication date: April 18, 2002
    Inventors: Michael J. Abrams, Simon P. Fricker, Barry A. Murrer, Owen John Vaughan
  • Patent number: 6365583
    Abstract: Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: April 2, 2002
    Assignee: AnorMED, Inc.
    Inventors: Ronald Trevor MacFarland, Andrew W. Millar, Gary Bridger, Michael J. Abrams, Geoffrey W. Henson
  • Patent number: 6284752
    Abstract: New pharmaceutical compositions and pharmaceutical compositions comprising metal complexes have activity against diseases caused by or related to overproduction or localised high concentration of nitric oxide in the body.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: September 4, 2001
    Assignee: AnorMED Inc.
    Inventors: Michael J Abrams, Simon P Fricker, Barry A Murrer, Owen J Vaughan
  • Patent number: 6217845
    Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: April 17, 2001
    Assignee: AnorMed, Inc.
    Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta