Patents by Inventor Michael J. Agostino

Michael J. Agostino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Site-specific integration
    Patent number: 11326185
    Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: May 10, 2022
    Assignees: LONZA BIOLOGICS PLC, PFIZER INC.
    Inventors: James Rance, Robert Young, Michael J. Agostino, Mark Moffat, Lin Zhang, Baohong Zhang
  • Site-specific integration
    Patent number: 10280436
    Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: May 7, 2019
    Assignees: LONZA BIOLOGICS PLC, PFIZER INC.
    Inventors: James Rance, Robert Young, Michael J. Agostino, Mark Moffat, Lin Zhang, Baohong Zhang
  • SITE-SPECIFIC INTEGRATION
    Publication number: 20190119702
    Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.
    Type: Application
    Filed: October 31, 2018
    Publication date: April 25, 2019
    Applicants: LONZA BIOLOGICS PLC, PFIZER INC.
    Inventors: James RANCE, Robert YOUNG, Michael J. AGOSTINO, Mark MOFFAT, Lin ZHANG, Baohong ZHANG
  • SITE-SPECIFIC INTEGRATION
    Publication number: 20150167020
    Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e.g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.
    Type: Application
    Filed: June 20, 2013
    Publication date: June 18, 2015
    Applicants: LONZA BIOLOGICS PLC, PFIZER INC.
    Inventors: James Rance, Robert Young, Michael J. Agostino, Mark Moffat, Lin Zhang, Baohong Zhang
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20080139452
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 12, 2008
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 7344861
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: March 18, 2008
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, II, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Aggrecanase molecules
    Patent number: 7125701
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: Michael J. Agostino, Lisa A. Racie
  • Aggrecanase molecules
    Patent number: 7078217
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: July 18, 2006
    Assignee: Wyeth
    Inventors: Christopher J. Corcoran, Michael J. Agostino, Edward R. LaVallie, Carl R. Flannery, Lisa A. Collins-Racie
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040248256
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa Collins-Racie, David Merberg, Cheryl Evans, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Michael R. Bowman, Elizabeth DiBlasio-Smith, Angela Widom
  • Map kinase phosphatases and polynucleotides encoding them
    Patent number: 6706869
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: March 16, 2004
    Assignee: Wyeth
    Inventors: Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Michael J. Agostino
  • Aggrecanase molecules
    Publication number: 20040044194
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 31, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Christopher J. Corcoran, Michael J. Agostino, Edward R. Lavallie, Carl R. Flannery, Weilan Zeng, Lisa A. Collins-Racie, Bethany A. Freeman
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040038276
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: July 8, 2003
    Publication date: February 26, 2004
    Applicant: GENETICS INSTITUTE, LLC.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Aggrecanase molecules
    Patent number: 6689599
    Abstract: Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: February 10, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Aggrecanase molecules
    Publication number: 20030228676
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: December 30, 2002
    Publication date: December 11, 2003
    Inventors: Michael J. Agostino, Elizabeth DiBlasio, Edward R. Lavallie, Bethany A. Freeman, Lisa A. Racie, Weilan Zeng
  • Aggrecanase molecules
    Publication number: 20030148306
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 5, 2002
    Publication date: August 7, 2003
    Inventors: Michael J. Agostino, Elizabeth Di Blasio, Edward R. LaVallie, Lisa A. Racie
  • Aggrecanase molecules
    Publication number: 20030105313
    Abstract: Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 25, 2002
    Publication date: June 5, 2003
    Applicant: American Home Products Corporation
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20030096951
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: May 22, 2003
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MICHAEL J. AGOSTINO, ROBERT STEININGER, VIKKI SPAULDING, GORDON G. WONG, HILARY F. CLARK, KIM FECHTEL, CHERYL EVANS, MAURICE TREACY
  • Aggrecanase molecules
    Publication number: 20030092621
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 26, 2002
    Publication date: May 15, 2003
    Inventors: Michael J. Agostino, Lisa A. Racie
  • Polynucleotides encoding novel secreted proteins
    Publication number: 20030027139
    Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.
    Type: Application
    Filed: March 29, 2001
    Publication date: February 6, 2003
    Inventors: Kenneth Jacobs, John McCoy, Edward R. LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Michael R. Bowman, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Steven H. Howes, Richard J. Resnick, Kalmalakar Gulukota, James R. Graham
  • Secreted expressed sequence tags (sESTs)
    Publication number: 20020173635
    Abstract: Secreted expressed sequence tags (sESTs) isolated from a varie
    Type: Application
    Filed: January 7, 2002
    Publication date: November 21, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino