Patents by Inventor Michael J. Avaltroni
Michael J. Avaltroni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8993117Abstract: Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.Type: GrantFiled: January 12, 2012Date of Patent: March 31, 2015Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Ellen S. Gawalt, Michael J. Avaltroni
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Patent number: 8758899Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: September 21, 2011Date of Patent: June 24, 2014Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Publication number: 20120121661Abstract: Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.Type: ApplicationFiled: January 12, 2012Publication date: May 17, 2012Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Ellen S. Gawalt, Michael J. Avaltroni
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Publication number: 20120114935Abstract: Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.Type: ApplicationFiled: January 12, 2012Publication date: May 10, 2012Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Ellen S. Gawalt, Michael J. Avaltroni
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Publication number: 20120012033Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: September 21, 2011Publication date: January 19, 2012Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 8092585Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: October 19, 2010Date of Patent: January 10, 2012Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Publication number: 20110093082Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: October 19, 2010Publication date: April 21, 2011Applicant: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 7879456Abstract: Methods for bonding adherent phosphorous-containing coating layers to oxide surfaces on substrates wherein the substrates with oxide surfaces are selected from: (a) oxidized iron, titanium, silicon, tin and vanadium; (b) indium tin oxide; and (c) substrates with oxide layers deposited thereon, wherein the substrates on which oxide layers are deposited are selected from ceramics, semiconductors, metals, plastics and glass, and the method contacts the oxide surface with a carrier conveying an organo-phosphonic acid coating composition and heats the oxide surface and carrier at a sufficient temperature while maintaining contact for a sufficient time to bond a layer of the organophosphonic acid to the oxide surface. Coated articles prepared by the inventive method are also disclosed.Type: GrantFiled: July 8, 2008Date of Patent: February 1, 2011Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman
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Patent number: 7815963Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: May 5, 2008Date of Patent: October 19, 2010Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 7569285Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: June 24, 2002Date of Patent: August 4, 2009Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael P. Danahy, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Michael D. Carolus, Ellen S. Gawalt
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Patent number: 7507483Abstract: An implantable device with a metal, metal alloy, metalloid, polymeric or ceramic surface and a phosphonic acid coating layer directly contacting the surface wherein the surface has hydroxyl groups covalently bonded to the acid groups of the coating layer and the phosphonate organic ligands are omega-functionalized.Type: GrantFiled: April 1, 2003Date of Patent: March 24, 2009Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael D. Carolus, Eric L. Hanson, Jean E. Schwarzbauer, Kim S. Midwood, Michael P. Danahy
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Publication number: 20090004481Abstract: Methods for bonding adherent phosphorous-containing coating layers to oxide surfaces on substrates wherein the substrates with oxide surfaces are selected from: (a) oxidized iron, titanium, silicon, tin and vanadium; (b) indium tin oxide; and (c) substrates with oxide layers deposited thereon, wherein the substrates on which oxide layers are deposited are selected from ceramics, semiconductors, metals, plastics and glass, and the method contacts the oxide surface with a carrier conveying an organo-phosphonic acid coating composition and heats the oxide surface and carrier at a sufficient temperature while maintaining contact for a sufficient time to bond a layer of the organophosphonic acid to the oxide surface. Coated articles prepared by the inventive method are also disclosed.Type: ApplicationFiled: July 8, 2008Publication date: January 1, 2009Applicant: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman
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Publication number: 20080206443Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: May 5, 2008Publication date: August 28, 2008Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen S. Gawalt
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Patent number: 7396594Abstract: The present invention provides a process for providing on the surface of a substrate an adherent phorphorous acid-based coating layer, the method comprising contacting said surface with a carrier conveying a coating composition comprising an acid selected from the group consisting of phosphoroic acids, organo-phosphoric acids, phosphonic acids, and mixtures thereof, at a sufficient temperature and for a sufficient time to bond at least a portion of the acid in the compositon to the oxide surface.Type: GrantFiled: June 23, 2004Date of Patent: July 8, 2008Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman
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Publication number: 20040023048Abstract: The present invention provides increased adhesion between the native oxide surface of a material and adhesive material or tissue by providing a phosphorous-based coating layer comprising a plurality of omega-functionalized organo-phosphonate moieties bonded to the native oxide surface of a substrate by a phosphonate bond and a plurality of one or more coating moieties selected from the group consisting of inorganic, organic, or bioactive moieties, each said coating moiety being bonded to the omega-functional group of at least one omega-functionalized organo-phosphonate moiety by means of a member of the group comprising a metal complex and an organic polymer, and when bonded by means of a metal complex, the metal complex further characterized by being derived from a metal alkoxide reagent, and when bonded by means of an organic polymer, the organic polymer further characterized by being derived from an ionic or step-reaction polymerization which incorporates one or more of said omega-functional groups into saType: ApplicationFiled: April 1, 2003Publication date: February 5, 2004Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael D. Carolus, Eric L. Hanson, Jean E. Schwarzbauer, Kim S. Midwood, Michael P. Danahy
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Publication number: 20040001959Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: June 24, 2002Publication date: January 1, 2004Inventors: Jeffrey Schwartz, Michael P. Danahy, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Michael D. Carolus, Ellen S. Gawalt