Abstract: The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one bioreducible ionizable cationic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.

Abstract: Provided herein are an apparatus, system, and method for a medical diagnostic and imaging forceps for determining the pathology of tissue in vivo during surgery, endoscopy, laparoscopy, or other medical procedure, the forceps comprising a platform for analyzing tissue pathology inside the body by way of sensors including without limitation conductivity, optical, tracking, and x-ray sensors.

Abstract: The present disclosure provides compositions and methods for delivering a polynucleotide from the exterior surface of a plant or plant part into the interior of a plant cell. More specifically, the present disclosure relates to compositions comprising at least one polynucleotide and at least one agent that is able to disrupt at least one barrier of the plant or plant part.

Abstract: Provided herein are an apparatus, system, and method for a medical diagnostic and imaging forceps for determining the pathology of tissue in vivo during surgery, endoscopy, laparoscopy, or other medical procedure, the forceps comprising a platform for analyzing tissue pathology inside the body by way of sensors including without limitation conductivity, optical, tracking, and x-ray sensors.

Abstract: The present disclosure provides compositions and methods for delivering a polynucleotide from the exterior surface of a plant or plant part into the interior of a plant cell. More specifically, the present disclosure relates to compositions comprising at least one polynucleotide and at least one agent that is able to disrupt at least one barrier of the plant or plant part.

Abstract: A surgical instrument has a hollow tubular member, and a pressurization unit that has an outer valve portion, a pressurization device having a movable part configured to generate pressurized fluid when the movable part is moved, and an inner valve portion. The inner valve portion includes a first flow passage that is configured to fluidically connect a first port and a second port of the outer valve portion to each other when the inner valve portion is in a first position, and a second flow passage that is configured between the inner valve portion and the outer valve portion to fluidically connect the first port and a third port when the inner valve portion is in a second position. A sealing system fluidically isolates the second port and the third port from each other at any position of the inner valve portion.

Abstract: An article including: a battery support containing battery lead wires attached to terminals; an opposing battery support attached to the battery support to create a battery closure; one or more batteries having battery contacts in the opposing battery support; and one or more activation tabs; wherein the terminals are attached to spring-loaded members; wherein the one or more activation tabs are spaced between the terminals and the battery contacts; wherein the spring-loaded members provide a biasing force that biases the terminals against the activation tabs keeping the one or more activation tabs in place in either a first position or a second position of the opposing battery support; wherein the opposing battery support is securely connected to the battery support in both the first position and the second position; and wherein the biasing force is greater in the second position than in the first position.

Abstract: An article comprising: (i) a handheld device including (a) a housing, (b) a powered element within the housing; (ii) a battery pack, wherein the handheld device is connected by an external cable to a functional system, wherein the battery pack is attached to the external cable, and wherein the battery pack supplies power to the powered element.

Abstract: A surgical instrument includes a hollow cylindrical member having a flexible region along at least a part of the hollow cylindrical member and a malleable tubing disposed over at least an outer surface of the flexible region of the hollow cylindrical member. The flexible region and the malleable tubing disposed over the flexible region can bend multiple times. The malleable tubing can maintain a bent orientation until the malleable tubing is re-bent by a user. The surgical instrument also includes connections that prevent the malleable tubing from moving longitudinally relative to the hollow cylindrical member. The malleable tubing may be made of various materials, one example of which is anodized, annealed aluminum.

Abstract: A surgical instrument includes a hollow cylindrical member having a flexible region along at least a part of the hollow cylindrical member and a malleable tubing disposed over at least an outer surface of the flexible region of the hollow cylindrical member. The flexible region and the malleable tubing disposed over the flexible region can bend multiple times. The malleable tubing can maintain a bent orientation until the malleable tubing is re-bent by a user. The surgical instrument also includes connections that prevent the malleable tubing from moving longitudinally relative to the hollow cylindrical member. The malleable tubing may be made of various materials, one example of which is anodized, annealed aluminum.

Abstract: A surgical instrument includes a hollow cylindrical member having a flexible region along at least a part of the hollow cylindrical member and a malleable tubing disposed over at least an outer surface of the flexible region of the hollow cylindrical member. The flexible region and the malleable tubing disposed over the flexible region can bend multiple times. The malleable tubing can maintain a bent orientation until the malleable tubing is re-bent by a user. The surgical instrument also includes connections that prevent the malleable tubing from moving longitudinally relative to the hollow cylindrical member. The malleable tubing may be made of various materials, one example of which is anodized, annealed aluminum.

Abstract: An article comprising: (i) a handheld device including (a) a housing, (b) a powered element within the housing; (ii) a battery pack, wherein the handheld device is connected by an external cable to a functional system, wherein the battery pack is attached to the external cable, and wherein the battery pack supplies power to the powered element.

Abstract: An article comprising: (i) a handheld device including (a) a housing, (b) a powered element within the housing: (ii) a battery pack, wherein the handheld device is connected by an external cable to a functional system, wherein the battery pack is attached to the external cable, and wherein the battery pack supplies power to the powered element.

Abstract: An article comprising: a battery support containing battery lead wires attached to terminals; an opposing battery support attached to the battery support to create a battery closure; one or more batteries having battery contacts in the opposing battery support; and one or more activation tabs; wherein the terminals are attached to spring-loaded members; wherein the one or more activation tabs are spaced between the terminals and the battery contacts; wherein the spring-loaded members provide a biasing force that biases the terminals against the activation tabs keeping the one or more activation tabs in place in either a first position or a second position; wherein the opposing battery support is securely connected to the battery support in both the first position and the second position; and wherein the biasing force is greater in the first position than in the second position.

Abstract: An article comprising: (a) a battery support containing battery lead wires, (b) an opposing battery support attached to the battery support to create a battery closure, and (c) one or more batteries; wherein the batteries are secured in the battery closure, wherein the batteries are secured to the opposing battery support, the batteries supply energy to a device, and removing the opposing battery support from the battery closure disables transmission of electricity from the batteries via the battery lead wires to the device.

Abstract: A surgical instrument has a hollow tubular member, and a pressurization unit that has an outer valve portion, a pressurization device having a movable part configured to generate pressurized fluid when the movable part is moved, and an inner valve portion. The inner valve portion includes a first flow passage that is configured to fluidically connect a first port and a second port of the outer valve portion to each other when the inner valve portion is in a first position, and a second flow passage that is configured between the inner valve portion and the outer valve portion to fluidically connect the first port and a third port when the inner valve portion is in a second position. A sealing system fluidically isolates the second port and the third port from each other at any position of the inner valve portion.

Abstract: An article comprising: (a) a battery support containing battery lead wires, (b) an opposing battery support attached to the battery support to create a battery closure, and (c) one or more batteries; wherein the batteries are secured in the battery closure, wherein the batteries are secured to the opposing battery support, the batteries supply energy to a device, and removing the opposing battery support from the battery closure disables transmission of electricity from the batteries via the battery lead wires to the device.

Abstract: An article comprising: (i) a handheld device including (a) a housing, (b) a powered element within the housing: (ii) a battery pack, wherein the handheld device is connected by an external cable to a functional system, wherein the battery pack is attached to the external cable, and wherein the battery pack supplies power to the powered element.

Abstract: A creep-resistant zircon article and a method of manufacturing the creep-resistant zircon article are described herein. In one example, the creep-resistant zircon article has the shape of a forming apparatus (e.g., isopipe) which is used in the fusion process to manufacture glass sheets.