Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A system and method for adjusting power employed by a light emitting device used for medical applications, such as measurement of patient parameter. A system or device includes a light emitting device, a power unit coupled to the light emitting device for powering the light emitting device and responsive to a control signal for adjusting power applied to the light emitting device, and a control unit for providing the control signal and coupled to the power unit, the control signal being determined in response to a characteristic of a signal associated with a physiological parameter measured using light produced by the light emitting device.

Abstract: A system and method for adjusting power employed by a light emitting device used for medical applications, such as measurement of patient parameter. A system or device includes a light emitting device, a power unit coupled to the light emitting device for powering the light emitting device and responsive to a control signal for adjusting power applied to the light emitting device, and a control unit for providing the control signal and coupled to the power unit, the control signal being determined in response to a characteristic of a signal associated with a physiological parameter measured using light produced by the light emitting device.

Abstract: A method for operating an oximeter sensor, and corresponding apparatus, which includes an encoded temperature characteristic of a light emitter in the sensor. The encoded temperature characteristic is read, and is used to modify a drive of the light emitter in the sensor. This enables a light emitter to be operated at its maximum allowable intensity to maximize a signal to noise ratio, without burning a patient, in accordance with the particular characteristics of that light emitter.

Abstract: An encoding element which is backward compatible and will provide a single coded value to older analyzers in response to first signal, but will also provide a second coded value to a new analyzer or monitor. In one embodiment, both coded values are provided over the same first and second leads which are compatible with existing sensors. In another embodiment, a first voltage level produces a first current from the encoding element, while a second voltage level will produce the second coded value. In another embodiment, a first coded value is provided in response to a DC current from older analyzers. A second coded value is provided in response to a AC signal from newer analyzers. Yet another embodiment provides the coded value in the form of a resonant circuit in the AC driven mode. In another embodiment, the first coded value is provided over the same two leads after a period of time, with the second value being provided prior to that period of time passing.

Abstract: The present invention provides an encoding mechanism for a medical sensor which uses a modulated signal to provide the coded data to a remote analyzer. The modulated signal could be, for instance, a pulse width modulated signal or a frequency modulated signal. This signal is amplitude independent and thus provides a significant amount of noise immunity.

Abstract: A method and apparatus for conserving power in a medical diagnostic apparatus by using a sleep mode during a monitoring state. The sleep mode allows not only the processor to be put to sleep, but other detection circuitry as well. This is accomplished by not relying on detecting events to awaken the sleeping circuitry, but rather establishing the stability of a physiological parameter before going to sleep. The invention monitors a physiological parameter of the patient and enters a sleep mode only after it has been stable for a predetermined period of time. The apparatus is periodically awakened from the sleep mode to take additional measurements and to ascertain that the stability of the physiological parameter has not changed. In one embodiment, the sleep period is chosen to be consistent with the period in which an alarm condition would need to be generated if a patient's condition started to quickly change.

Abstract: The present invention provides an encoding mechanism for a medical sensor which uses a modulated signal to provide the coded data to a remote analyzer. The modulated signal could be, for instance, a pulse width modulated signal or a frequency modulated signal. This signal is amplitude independent and thus provides a significant amount of noise immunity.

Abstract: A method and apparatus for conserving power in a medical diagnostic apparatus by using a sleep mode during a monitoring state. The invention monitors physiological parameters of the patient and enters a sleep mode only after they have been stable for a predetermined period of time. The apparatus is periodically awakened from the sleep mode to take additional measurements and to ascertain that the stability of the physiological parameters has not changed.

Abstract: The present invention provides an encoding mechanism for a medical sensor which uses a modulated signal to provide the coded data to a remote analyzer. The modulated signal could be, for instance, a pulse width modulated signal or a frequency modulated signal. This signal is amplitude independent and thus provides a significant amount of noise immunity.