Patents by Inventor Michael J. Bollong

Michael J. Bollong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE ACTIVATORS OF YAP TRANSCRIPTIONAL ACTIVITY FOR REGENERATIVE ORGAN REPAIR
    Publication number: 20240148747
    Abstract: The present disclosure provides compounds, or their tautomers or pharmaceutically acceptable salts thereof, and their pharmaceutical compositions that can selectively activate Yes-associated protein 1 (YAP). YAP activators of the present disclosure are useful in therapies such as wound and organ repair including, for example, treatment of chronic ulcers.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 9, 2024
    Inventors: Michael J. Bollong, Peter G. Schultz, Arnab Chatterjee, Weijun Shen, Elshan Nakath G. Ralalage, Edyta M. Grzelak, Pengyu Yang
  • SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES
    Publication number: 20240115577
    Abstract: The present disclosure relates to compounds. and to their pharmaceutical compositions. that inhibit dipeptidyl peptidase IV (DPP4). Hie compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology. for example. derives from epithelial degeneration and maladaptive remodeling, such as pulmonary' diseases like idiopathic pulmonary fibrosis (IFF), acute respiratory' distress syndrome (ARDS), and infant respiratory' distress syndromes (IRDS).
    Type: Application
    Filed: January 14, 2022
    Publication date: April 11, 2024
    Inventors: Michael J. Bollong, Peter G. Schultz, Sida Shao, Arnab Chatterjee, Jian Jeffrey Chen, Nan Zhang
  • SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES
    Publication number: 20230346781
    Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
    Type: Application
    Filed: July 11, 2023
    Publication date: November 2, 2023
    Applicants: The Scripps Research Institute, Board of Regents, The University of Texas System
    Inventors: Luke L. LAIRSON, Michael J. BOLLONG, Peter G. SCHULTZ, Sendurai A. Mani
  • Small molecule inhibitors of cancer stem cells and mesenchymal cancer types
    Patent number: 11759461
    Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: September 19, 2023
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, THE UNIVERSTY OF TEXAS SYSTEM,BOARD OF REGENTS
    Inventors: Luke L. Lairson, Michael J. Bollong, Peter G. Schultz, Sendurai A. Mani
  • SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES
    Publication number: 20210196713
    Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
    Type: Application
    Filed: October 30, 2018
    Publication date: July 1, 2021
    Applicants: The Scripps Research Institute, Board of Regents, The University of Texas System
    Inventors: Luke L. Lairson, Michael J. Bollong, Peter G. Schultz, Sendurai A. Mani