Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A fire-resistant, aluminum, cementitious-material-free, insulation-free door adapted to prevent the spread of fire and heat passing therethrough, consists of: a door frame, a door hingedly mounted on the door frame, the door having a bottom wall, a top wall, and side walls, the bottom wall, top wall and side walls enclosing a hollow central core not containing substantial amounts of insulating material, the bottom wall having an outside surface, and the top wall having an outside surface; and a layer of intumescent material on the outside surface of the bottom wall. A heat-activated self-closing mechanism allows the weight of the door to close the door in the vent of fire, by releasing gas from a supporting gas spring.

Abstract: A single layer sound insulated door assembly, and automatically releasing latch to open the door assembly in response to predetermined indicators of fire in the structure and a labyrinthine seal mechanism which limits sound transmission through the door assembly. An acoustical smoke vent is sound insulated and the doors are sealed to the curb by means of a unique labyrinthine gasket assembly effective at limiting sound transmission through the vent. The acoustical smoke vent of the present invention achieves a sound transmission class of STC 45 or better without the need for double layer door assemblies.

Abstract: A fire-resistant, aluminum, cementitious-material-free, insulation-free door adapted to prevent the spread of fire and heat passing therethrough, consists of: a door frame, a door hingedly mounted on the door frame, the door having a bottom wall, a top wall, and side walls, the bottom wall, top wall and side walls enclosing a hollow central core not containing substantial amounts of insulating material, the bottom wall having an outside surface, and the top wall having an outside surface; and a layer of intumescent material on the outside surface of the bottom wall. A heat-activated self-closing mechanism allows the weight of the door to close the door in the vent of fire, by releasing gas from a supporting gas spring.

Abstract: A fire-resistant, aluminum, cementitious-material-free, insulation-free door adapted to prevent the spread of fire and heat passing therethrough, consists of: a door frame; a door hingedly mounted on the door frame, the door having a bottom wall, a top wall, and side walls, the bottom wall, top wall and side walls enclosing a hollow central core not containing substantial amounts of insulating material, the bottom wall having an outside surface, and the top wall having an outside surface; and a layer of intumescent material on the outside surface of the bottom wall. A heat-activated self-closing mechanism allows the weight of the door to close the door in the event of fire, by releasing gas from a supporting gas spring.

Abstract: An automatic sheet loader for sheets of photographic film or the like is provided. A first drive assembly is used to drive a sheet of imaging material from a supply toward an imaging station. A second drive assembly, independent of the first drive assembly, drives the sheet of imaging material into the imaging station and subsequently retrieves the sheet from the imaging station. An ejection solenoid is used to eject the sheet from the imaging station for retrieval. During a loading cycle, the first and second drive assemblies are actuated to load the sheet into the imaging station. During a retrieval cycle, the ejection solenoid and second drive means are actuated to retrieve the sheet from the imaging station and drive it into an exposed sheet chamber without loading another sheet into the imaging station. A solenoid actuated light trap is provided between the supply and exposed sheet chambers and the imaging station.

Abstract: The invention of the present document comprises apparatus for receiving and automatically feeding dual-in-line package (DIP) transportation and storage tubes (24) to the singulator (76) of an integrated circuit device handler (20) so that devices (22) in the tubes (24) can be introduced at the singulator (76). The tubes (24) are randomly placed in a hopper (66), and conveyed through an aperture (170) formed in a side wall (172) of the hopper (66). An elevator (74) is provided to raise the tubes (24) to a height at which open ends thereof are disposed above the height of the singulator (76). With a tube (24) so raised, a tube inserter (96) pushes the tube (24) into the tube holder (98) of a manipulator (100). The tube holder (98) is, in turn, pivoted to tilt the tube (24) so that devices (22) within the tube (24) are deposited for introduction into the singulator (76 ).