Patents by Inventor Michael J. Castaldi

Michael J. Castaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of benzoimidazole derivatives
    Patent number: 7183414
    Abstract: The present invention relates to a process for preparing a compound of the formula I or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof, wherein R1, R2, R3 and R4 are as defined herein. The compound of formula I is useful in the treatment of abnormal cell growth, such as cancer, in mammals.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: February 27, 2007
    Assignee: Pfizer Inc
    Inventors: Norma J. Tom, Michael J. Castaldi, David B. Ripin
  • Crystalline anhydrous and monohydrate benzoate salts of (2?S,3S)-3-hydroxy-N-(2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl)-ethylpyrrolidine
    Patent number: 7038061
    Abstract: A process for preparing an anhydrous benzoate salt in crystalline form having the formula I: and the corresponding benzoate monohydrate in crystalline form. The benzoate salts and pharmaceutical compositions thereof are selective kappa-receptor agonists, and are useful as analgesics, anesthetics, anti-inflammatory or neuroprotective agents, or in the treatment of arthritis, stroke or functional bowel disease.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: May 2, 2006
    Assignee: Pfizer Inc
    Inventors: George J. Quallich, Michael J. Castaldi
  • Heterocyclo-alkylsulfonyl pyrazole derivatives
    Patent number: 6846930
    Abstract: The invention relates to compounds of formula 4: Wherein R1-R4 are defined as in the specification.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: January 25, 2005
    Assignee: Pfizer Inc.
    Inventors: Dennis E. Bourassa, Michael J. Castaldi, David B. Ripin
  • Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine
    Publication number: 20040266832
    Abstract: The invention concerns crystalline forms of 2-(3-difluromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine, their preparation and use in pharmaceuticals.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 30, 2004
    Inventors: Zheng J. Li, Robert J. Rafka, David H. B. Ripin, Michael J. Castaldi
  • Crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl-ethylpyrrolidine
    Publication number: 20040235936
    Abstract: A process for preparing an anhydrous benzoate salt in crystalline form having the formula I: 1
    Type: Application
    Filed: April 23, 2003
    Publication date: November 25, 2004
    Applicant: Pfizer Inc.
    Inventors: George Quallich, Michael J. Castaldi
  • Novel processes and intermediates for preparing triazolo-pyridines
    Publication number: 20040053959
    Abstract: The present invention relates and intermediates to a novel process for preparing triazolo-pyridines of the formula I 1
    Type: Application
    Filed: August 27, 2003
    Publication date: March 18, 2004
    Applicant: Pfizer Inc.
    Inventors: Richard A. Buzon, Michael J. Castaldi, Zhengong B. Li, David H. B. Ripin, Yong Tao
  • Process for preparing heterocyclo-alkylsulfonyl pyrazole derivatives
    Publication number: 20040044042
    Abstract: The invention relates to processes for preparing compounds of formula 1: 1
    Type: Application
    Filed: August 25, 2003
    Publication date: March 4, 2004
    Applicant: Pfizer Inc
    Inventors: Dennis E. Bourassa, Michael J. Castaldi, David B. Ripin
  • Process for preparing heterocyclo-alkylsulfonyl pyrazole derivatives
    Patent number: 6646128
    Abstract: The invention relates to processes for preparing compounds of formula 1: as well as intermediates useful in such processes, wherein R1-R4 are as defined herein. The compounds of formula 1 are useful in the treatment or alleviation of inflammation and other inflammation associated disorders.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: November 11, 2003
    Assignee: Pfizer Inc.
    Inventors: Dennis E. Bourassa, Michael J. Castaldi, David B. Ripin
  • Process for preparing heterocyclo-alkysulfonyl pyrazole derivatives
    Publication number: 20030100765
    Abstract: The invention relates to processes for preparing compounds of formula 1: 1
    Type: Application
    Filed: September 27, 2002
    Publication date: May 29, 2003
    Applicant: Pfizer Inc.
    Inventors: Dennis E. Bourassa, Michael J. Castaldi, David B. Ripin
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6444826
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: September 3, 2002
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processesand intermediatesfor preparing substitutedchromanol derivatives
    Publication number: 20020099227
    Abstract: The invention relates to processes for preparing a compound of the formula 1
    Type: Application
    Filed: October 31, 2001
    Publication date: July 25, 2002
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processesand intermediatesfor preparing substitutedchromanol derivatives
    Publication number: 20020042526
    Abstract: The invention relates to processes for preparing a compound of the formula 1
    Type: Application
    Filed: March 21, 2001
    Publication date: April 11, 2002
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6355825
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: March 12, 2002
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6288242
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: September 11, 2001
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processes for preparing substituted chromanol derivatives
    Patent number: 6096906
    Abstract: The invention relates to processes for preparing a compound of the formula (X) and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R.sup.1, R.sup.2 and R.sup.3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula (X).
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: August 1, 2000
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
    Patent number: 5939550
    Abstract: A multi-step process for preparing a dipeptide derivative of 7-(6-amino-3-azabicyclo?3.1.0.!hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1 ,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, in the form of a pharmaceutically acceptable acid addition salt is disclosed.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: August 17, 1999
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Michael J. Castaldi, Harry A. Watson, Jr.