Patents by Inventor Michael J. Caterina

Michael J. Caterina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
    Patent number: 7097991
    Abstract: The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: August 29, 2006
    Assignee: The Regents of the University of California
    Inventors: David J. Julius, Michael J. Caterina, Anthony J. Brake
  • Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
    Patent number: 6790629
    Abstract: The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 14, 2004
    Assignee: The Regents of the University of California
    Inventors: David J. Julius, Michael J. Caterina, Anthony J. Brake
  • Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
    Publication number: 20030049728
    Abstract: The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample.
    Type: Application
    Filed: October 15, 2001
    Publication date: March 13, 2003
    Inventors: David J. Julius, Michael J. Caterina, Anthony J. Brake
  • Nucleic acid sequences encoding capsaicin receptor and uses thereof
    Patent number: 6335180
    Abstract: The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: January 1, 2002
    Assignee: The Regents of the University of California
    Inventors: David J. Julius, Michael J. Caterina, Anthony J. Brake