Abstract: A technique for removing loose powder from the interior surfaces of ceramic molds made using layer manufacturing processes, such as three dimensional printing processes. The interior of a mold is filled with water which is boiled and the particles are entrained in the flow caused by the boiling liquid. In another technique, the mold is immersed in water charged with CO.sub.2 and the pressure rapidly dropped to cause the CO.sub.2 to come out of solution as bubbles which eject the particles. Alternatively, fine particles are introduced into the mold and the mold is agitated to dislodge the particles and the powder so that they can be poured out of the mold. Such technique tends also to remove the surface finish of the mold. Any of the particles which remain can be dissolved in a liquid and removed in the liquid from the mold.

Abstract: Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or ion beam (dry) etching techniques well known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. The molecules to be delivered are inserted into the reservoirs by injection or spin coating methods in their pure form or in a release system. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules.

Abstract: Solid free-form techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

Abstract: Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of Cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

Abstract: A technique for removing loose powder from the interior surfaces of ceramic molds made using layer manufacturing processes, such as three dimensional printing processes. The interior of a mold can be filled with liquid, such as water, which is boiled by applying microwave energy of a frequency selected to heat the liquid. The particles are entrained in the flow caused by the boiling liquid. Alternatively, fine particles are introduced into the mold and the mold is agitated to dislodge the particles and the powder so that they can be poured out of the mold. Such technique tends also to remove the surface finish of the mold. Any of the particles which remain can be dissolved in a liquid and removed in the liquid from the mold. Further, the surface finish of the mold can be improved by casting a slip of fine particles onto the surface to form a generally level, and preferably non-conformal, coating on the surfaces.

Abstract: A process for making a component by depositing a first layer of a powder material in a confined region and then depositing a binder material to selected regions of the layer of powder material to produce a layer of bonded powder material at the selected regions. Such steps are repeated a selected number of times to produce successive layers of selected regions of bonded powder material so as to form the desired component. The unbonded powder material is then removed. In some cases the component may be further processed as, for example, by heating it to further strengthen the bonding thereof.

Abstract: Highly-textured superconductor oxide thin films are prepared on substrates, including lattice matched, non-lattice matThe Government has rights in this invention pursuant to contract Number MDA972-88-K0006 awarded by the U.S. Defense Advance Research Project Agency.

Abstract: A process for making a component by depositing a first layer of a fluent porous material, such as a powder, in a confined region and then depositing a binder material to selected regions of the layer of powder material to produce a layer of bonded powder material at the selected regions. Such steps are repeated a selected number of times to produce successive layers of selected regions of bonded powder material so as to form the desired component. The unbonded powder material is then removed. In some cases the component may be further processed as, for example, by heating it to further strengthen the bonding thereof.