Patents by Inventor Michael J. Cleare

Michael J. Cleare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibody-platinum co-ordination compound complex
    Patent number: 4952676
    Abstract: A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilizes the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: August 28, 1990
    Assignee: Johnson Matthey PLC
    Inventors: James G. Heffernan, Michael J. Cleare, Donald H. Picker
  • Platinum co-ordination compounds
    Patent number: 4760156
    Abstract: A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilises the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: July 26, 1988
    Inventors: James G. Heffernan, Michael J. Cleare, Donald H. Picker
  • Malonato platinum compounds
    Patent number: 4657927
    Abstract: Malonato platinum coordination compounds and a method of treating malignant tumors sensitive to a planar dsp.sup.2 platinum (II) coordination compound or an octahedral d.sup.2 sp.sup.3 platinum (IV) coordination compound comprising the parenteral administration to an affected animal of a solution of the compound.
    Type: Grant
    Filed: May 25, 1983
    Date of Patent: April 14, 1987
    Assignee: Research Corporation
    Inventors: Michael J. Cleare, James D. Hoeschele, Barnett Rosenberg, Loretta Van Camp
  • Staining with nitrido-bridged osmium or ruthenium compounds
    Patent number: 4235868
    Abstract: This invention relates to the staining of cells, and in particular provides a novel reagent for the detection, for example, of DNA (deoxyribonucleic acid) and polysaccharides by electron microscopy.A reagent for staining cells in accordance with the present invention comprises an aqueous solution of a nitrido-bridged complex of osmium or ruthenium and having the general formula:[M.sub.2.sup.IV N(NH.sub.3).sub.8-2x X.sub.5-y (H.sub.2 O).sub.x ]Y.sub.y.where M represents either Os or Ru, X and Y are the same or different anions selected from nitrate, halide and pseudohalide, x is 0 or 1 and y is 2 or 3.
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: November 25, 1980
    Assignee: Johnson, Matthey & Co., Limited
    Inventors: Michael J. Cleare, Paul C. Hydes
  • Osmium compounds
    Patent number: 4148870
    Abstract: This specification describes a complex of osmium tetroxide and a compound having a heterocyclic ring containing one or two tertiary nitrogen atoms. The compound may be an aromatic tertiary amine and the tertiary nitrogen atom may be the sole heterocyclic atom in the heterocyclic ring. The complexes described are suitable for fixing and staining cells and may be used in the preparation of biological specimens for examination by electron microscopy.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: April 10, 1979
    Assignee: Johnson, Matthey & Co., Limited
    Inventors: Paul C. Hydes, Michael J. Cleare
  • Malonato platinum anti-tumor compounds
    Patent number: 4140707
    Abstract: Malonato platinum coordination compounds and a method of treating malignant tumors comprising the parenteral administration to an affected animal of a solution of the compound.
    Type: Grant
    Filed: March 18, 1977
    Date of Patent: February 20, 1979
    Assignee: Research Corporation
    Inventors: Michael J. Cleare, James D. Hoeschele, Barnett Rosenberg, Loretta L. Van Camp