Abstract: Systems, computer-readable media, and methods are presented that identify suspicious anomalies in a colon with higher sensitivity and at a lower false positive rate. A plurality of images of an anatomical colon is acquired. Candidate suspicious anomalies are identified in each image. The candidate suspicious anomalies across images are then compared using registration and matching. Features of candidate suspicious anomalies across images may be jointly evaluated to perform classification.

Abstract: Methods are presented that detect and classify mass-like regions exhibiting spiculated and/or dense characteristics with high sensitivity and at acceptable false positive rates. One or more suspicious masses are identified in medical imagery of the breast. In certain embodiments, a quantitative measure of spiculation and quantitative measure of density are computed for each suspicious mass located. At least one classification scheme, developed using true and false positives with similar quantitative measures, is then selected for each suspicious mass according to both quantitative measures. In certain other embodiments, a measure of breast location is computed for each suspicious mass. In one embodiment, the location determines whether a suspicious mass appears inside or outside of the parenchyma region of the breast.

Abstract: A structured prediction model learning apparatus, method, program, and recording medium maintain prediction performance with a smaller amount of memory. An auxiliary model is introduced by defining the auxiliary model parameter set ?(k) with a log-linear model. A set ? of auxiliary model parameter sets which minimizes the Bregman divergence between the auxiliary model and a reference function indicating the degree of pseudo accuracy is estimated by using unsupervised data. A base-model parameter set ? which minimizes an empirical risk function defined beforehand is estimated by using supervised data and the set ? of auxiliary model parameter sets.

Abstract: A direct rapid automated protein analyzer is disclosed. The protein analyzer includes means for reducing protein samples to small particles, a reaction vessel in material transfer communication with the homogenizer, a reservoir for binding dye composition in fluid communication with the reaction vessel, a metering pump in fluid communication with the reservoir and the reaction vessel for distributing discrete predetermined amounts of a binding dye composition to the reaction vessel, a filter in fluid communication with the reaction vessel for separating solids from filtrate after a dye binding reaction has taken place in the reaction vessel, and a calorimeter in fluid communication with the filter and the reaction vessel for measuring the absorbance of the filtrate from the reaction vessel and the filter. The rapid analyzer can be used in conjunction with a kit that includes a sample cup for mixing a protein sample with a dye-binding solution and a filter holder for being positioned in the sample cup.

Abstract: Methods and systems are presented that improve a radiologist's ability to identify polyps by automatically and more accurately detecting and displaying colonic residue such as tagged or untagged stool or colonic fluid in medical images of the colorectal region. A virtual colonography imaging system obtains medical imagery of the colon. Improved computer-aided detection (CAD) algorithms identify colonic residue in the imagery by calculating feature vectors of and using statistical classification methods to classify regions of colonic residue to distinguish them from false positives.

Abstract: An instrument and associated method are disclosed for the loss-on-drying determination of the volatile content of a wide variety of samples.

Abstract: The invention provides methods for designing ophthalmic lenses, and lenses produced by this method, which lenses corrects both low order and high order wavefront aberrations of the lens wearer's eyes.

Abstract: A protein analysis kit is disclosed. The kit includes a sample cup for mixing a protein sample with a dye-binding solution and a filter holder for being positioned in the sample cup. The filter holder includes a filter media and a depending spout below the filter media that reaches bottom portions of the cup when the filter media is positioned above the cup.

Abstract: The disclosure relates to a prefabricated framing member support system and methods for installing such a system with a horizontal framing member, the horizontal framing member having a top chord, a bottom chord, a web connecting the top chord to the bottom chord and a framing member cross sectional end profile. The prefabricated support system includes an integrated rim board component having a substantially L-shaped cross sectional end profile. The integrated rim board component includes a substantially vertical portion and a substantially horizontal portion.

Abstract: Systems, computer-readable media, methods, and a medical imaging system are presented that compute and output a density estimate of a breast. The density estimate may be computed using information from at least two digital images, wherein each image represents a view of at least a portion of the breast from a different specific angle. The density estimate may be computed using information from at least one digital breast image and at least one digital opposite breast image, wherein the at least one digital breast image represents a view of at least a portion of the breast from a specific angle and wherein the at least one digital opposite breast image represents a view of at least a portion of the opposite breast. The density estimate may be computed using computed parenchyma information, the parenchyma information being computed using texture information and density information derived from at least one digital image of at least a portion of the breast.

Abstract: A contact lens having one or more fiducial marks that allow the measurement of lens rotation and centration. The lens may be a trial lens. The lenses can be used to apply correction factors for sphero-cylindrical refractive error, higher order aberrations, and corneal topography.

Abstract: Lenses are designed using the corneal topography or wavefront measurements of the eye derived by subtracting the optical power of the eye after orthokeratology treatment from the optical power before orthokeratology treatment.

Abstract: A protein analysis kit is disclosed. The kit includes a sample cup for mixing a protein sample with a dye-binding solution and a filter holder for being positioned in the sample cup. The filter holder includes a filter media and a depending spout below the filter media that reaches bottom portions of the cup when the filter media is positioned above the cup.

Abstract: A dye binding method for protein analysis is disclosed. The method includes the steps of preparing an initial reference dye solution of unknown concentration from an initial reference dye concentrate and creating an electronic signal based upon the absorbance of the initial reference dye solution. Thereafter, an electronic signal is created based upon the absorbance of a dye filtrate solution prepared from the initial reference dye solution and an initial protein sample. The absorbance signals from the reference dye solution and the dye filtrate solution are sent to a processor that compares the respective absorbances and calculates the protein content of the protein sample based upon the difference between the absorbances.

Abstract: Systems, computer-readable media, and methods are presented that identify suspicious anomalies in a colon with higher sensitivity and at a lower false positive rate. A plurality of images of an anatomical colon is acquired. Candidate suspicious anomalies are identified in each image. The candidate suspicious anomalies across images are then compared using registration and matching. Features of candidate suspicious anomalies across images may be jointly evaluated to perform classification.

Abstract: The invention provides methods for designing ophthalmic lenses, and lenses produced by this method, which lenses corrects both low order and high order wavefront aberrations of the lens wearer's eyes.

Abstract: A method and system that provides users with additional information regarding imagery analyzed by computer-aided detection (CAD) systems is described. A user selects a region of the analyzed imagery. Information is then derived from computational measurements of the region obtained during CAD processing. The region selected by the user does not necessarily have to include a displayed CAD system detection. The information includes a description of the computational measurement and the value of the measurement, both of which are provided in clinically relevant terms.

Abstract: Lenses are designed using wavefront measurements amenable to correction factors for near and far vision as well as pupil size to slow or stop myopia progression.

Abstract: Disclosed are methods, and associated systems comprising processors, input devices and output devices, of detecting regions of interest in a tomographic breast image. The methods may comprise: acquiring tomographic breast image data; deriving a plurality of synthetic sub-volumes from the tomographic breast image data; wherein each subvolume is defined by parallel planar top and bottom surfaces; wherein planar top and bottom surfaces of successive subvolumes are parallel to each other; and wherein a top planar surface of a sub-volume is offset from a top planar surface of a prior sub-volume, such that successive sub-volumes overlap; for each sub-volume, deriving a two-dimensional image; for each two-dimensional image, identifying regions of interest therein; deriving at least one region of interest of potential clinical interest from a plurality of identified regions of interest; and outputting information associated with at least one derived region of interest of potential clinical interest.

Abstract: The invention provides methods for designing ophthalmic lenses, and lenses produced by this method, which lenses corrects both low order and high order wavefront aberrations of the lens wearer's eyes.