Patents by Inventor Michael J. Costanzo

Michael J. Costanzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidyl heterocyclic ketones useful as tryptase inhibitors
    Patent number: 6469036
    Abstract: The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: October 22, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff, Stephen C. Yabut
  • Methods for treating immunomediated inflammatory disorders
    Patent number: 6323219
    Abstract: This invention relates to methods ands compositions for bringing about changes in skin pigmentation and for treating inflammatory disorders. More particularly, this invention relates to compounds which affect melanogenesis and can be used as depigmenting agents or as agents for darkening skin utilizing the PAR-2 pathway and compounds for the, prevention and treatment of immunomediated inflammatory diseases, particularly those associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: November 27, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Michael J. Costanzo
  • Carboxamide derivatives of piperidine for the treatment of thrombosis disorders
    Patent number: 6069254
    Abstract: Carboxamide derivatives of pyrrolidine, piperidine, and hexahydroazepine of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: May 30, 2000
    Assignee: Ortho Pharmaceutical Corp.
    Inventors: Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff
  • Peptidyl heterocycles useful in the treatment of thrombin related disorders
    Patent number: 5827866
    Abstract: Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 27, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Peptidyl heterocycles useful in the treatment of thrombin related disorders
    Patent number: 5827860
    Abstract: Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 27, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Peptidyl heterocycles useful in the treatment of thrombin related disorders
    Patent number: 5523308
    Abstract: Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 4, 1996
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Anticonvulsant sorbopyranose sulfamates
    Patent number: 5384327
    Abstract: Sulfamate derivatives having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are as herein defined, have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, the present invention encompasses pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and novel intermediates are disclosed.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 24, 1995
    Assignee: McNeilab, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Anticonvulsant fructopyranose cyclic sulfites and sulfates
    Patent number: 5242942
    Abstract: Compounds of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n and p are as herein defined; exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Compounds of this class are also useful for the treatment of glaucoma, peptic ulcers, hypertension, congestive heart failure and other types of edema. Furthermore, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and novel intermediates are disclosed.
    Type: Grant
    Filed: April 28, 1992
    Date of Patent: September 7, 1993
    Assignee: McNeilab, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff