Patents by Inventor Michael J. Coyne

Michael J. Coyne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for overexpression of zwitterionic polysaccharides
    Patent number: 7803602
    Abstract: The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: September 28, 2010
    Assignee: The Brigham and Woman's Hospital, Inc.
    Inventors: Laurie E. Comstock, Katja G. Weinacht, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos
  • Method for overexpression of zwitterionic polysaccharides
    Patent number: 7678558
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: March 16, 2010
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie E. Comstock, Katja G. Weinacht, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos
  • Method for overexpression of zwitterionic polysaccharides
    Patent number: 7166455
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: January 23, 2007
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie E. Comstock, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos, Katja G. Weinacht
  • Method for overexpression of zwitterionic polysaccharides
    Publication number: 20030219413
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Application
    Filed: March 13, 2003
    Publication date: November 27, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie E. Comstock, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos, Katja G. Weinacht
  • Method of measuring the duration of adequate immune memory in companion animals
    Publication number: 20020058039
    Abstract: Methods to measure the duration of adequate immune memory for animal vaccines involving a retrospective analysis utilizing veterinary vaccine administration histories and clinical histories, and markers of immunity of animals in the field to derive a vaccine's duration of adequate immune memory.
    Type: Application
    Filed: April 19, 2001
    Publication date: May 16, 2002
    Inventors: Michael J. Coyne, Dennis J. Kowalski, David R. McGavin, Michael K. O'Hara