Patents by Inventor Michael J. Donovan

Michael J. Donovan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190316817
    Abstract: A thermal management system for regulating dissipation of multiple thermal loads during operation of an apparatus includes a two-phase pump loop (TPPL), a vapor cycle system (VCS), and a liquid thermal energy storage (TES) system integrated together to maintain the apparatus at a constant temperature. The TPPL is configured to remove heat from the apparatus; the TES system is configured to provide thermal energy storage and temperature regulation; and the VCS is configured to transfer heat to the environment. The multiple thermal loads include a primary thermal load in the form of heat from the apparatus and a secondary thermal load in the form of at least one of a housekeeping thermal load or a power electronics thermal load. The primary and secondary loads are at different temperatures with each being independently selected to be transient or steady state.
    Type: Application
    Filed: August 8, 2018
    Publication date: October 17, 2019
    Inventors: Eric S. Donovan, Michael J. Head, Ken S. Rubel, Brian T. Spangler, Douglas J. Snyder, Aric Acius
  • Publication number: 20190306716
    Abstract: A system and method in which the Bluetooth technology is used in conjunction with a user application on a mobile device to facilitate hands-free fare validation at a transit station. The user app communicates with a controller driver in a controller unit that interfaces with a compliant fare gate. Bluetooth beacons are used to determine a passenger's proximity to the gate and camera-like devices determine whether a passenger has entered a fare validation zone. A user with a valid and active electronic ticket on their mobile device may simply walk through the fare gate “hands free” without the need to search for a physical ticket or a smartcard or a mobile phone. This hassle-free approach significantly improves the user experience and passenger throughput through fare gates. The Bluetooth-based automated fare validation system also detects passengers with valid electronic tickets and those without a valid permit for travel.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 3, 2019
    Inventors: Micah Bergdale, Nicholas Ihm, Kevin Rejko, Michael O'Haire, Edward J. Donovan
  • Publication number: 20190276897
    Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.
    Type: Application
    Filed: March 1, 2019
    Publication date: September 12, 2019
    Inventors: Michael J. Donovan, Anna COLOMER VALERO, Nadina ERILL SAGALES, Isidre FERRER ABINZANDA, Susana BOLUDA CASAS
  • Patent number: 10375573
    Abstract: A system and method in which the Bluetooth technology is used in conjunction with a user application on a mobile device to facilitate hands-free fare validation at a transit station. The user app communicates with a controller driver in a controller unit that interfaces with a compliant fare gate. Bluetooth beacons are used to determine a passenger's proximity to the gate and camera-like devices determine whether a passenger has entered a fare validation zone. A user with a valid and active electronic ticket on their mobile device may simply walk through the fare gate “hands free” without the need to search for a physical ticket or a smartcard or a mobile phone. This hassle-free approach significantly improves the user experience and passenger throughput through fare gates. The Bluetooth-based automated fare validation system also detects passengers with valid electronic tickets and those without a valid permit for travel.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: August 6, 2019
    Inventors: Micah Bergdale, Nicholas Ihm, Kevin Rejko, Michael O'Haire, Edward J. Donovan
  • Publication number: 20190178433
    Abstract: A tool system comprises a crawler, one or more tool interfaces, one or more tools operatively in communication with at least one the tool interface and adapted to perform a predetermined function in an interior of a predefined space, and a power interface. The tool system is deployed within the interior of the predefined space, e.g. a drilling riser, typically after operatively attaching a tool to a tool interface. Power is to the tool system which is moved to a position within the interior of where a predetermined function is to occur and the tool used to perform the predetermined function at the position within the interior of the predefined space where the predetermined function is to occur. In an embodiment, tool system comprises a first tool adapted to perform a first predefined function, e.g. a cleaning function, and second tool adapted to perform a second predefined function, e.g. an inspection function, where the two functions may be performed in a single pass of the tool system in the interior.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 13, 2019
    Applicant: Oceaneering International, Inc.
    Inventors: Patrick J Donovan, Michael William Killeen, Daniel J. Scoville, Mark Alan Stevens, Rajashekar Venkatachalam
  • Publication number: 20150111907
    Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Inventors: Michael J. DONOVAN, Anna Colomer Valero, Nadina Erill Sagales, Isidre Ferrer Abinzanda, Susana Boluda Casas
  • Patent number: 8853163
    Abstract: The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: October 7, 2014
    Assignees: Cornell Research Foundation, Inc., Children's Medical Center Corporation
    Inventors: Barbara L. Hempstead, Rosemary Kraemer, Shahin Rafii, Phi Wiegn, Michael J. Donovan
  • Patent number: 8062897
    Abstract: The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be detected simultaneously using between 8 and 82 probes for each nascent RNA. The invention comprises, in addition, methods of preparing a sample for nascent RNA detection by reducing autofluorescence of the tissue sample. These techniques may be synergistically combined to achieve significantly improved results.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 22, 2011
    Assignee: Aureon Laboratories, Inc.
    Inventors: Paola Capodieci, Michael J. Donovan
  • Publication number: 20110166409
    Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.
    Type: Application
    Filed: December 7, 2010
    Publication date: July 7, 2011
    Inventors: Michael J. Donovan, Anna Colomer Valero, Nadina Erill Sagales, Isidre Ferrer Abizanda, Susana Boluda Casas
  • Publication number: 20100227823
    Abstract: The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.
    Type: Application
    Filed: May 21, 2010
    Publication date: September 9, 2010
    Applicants: CORNELL RESEARCH FOUNDATION, INC., CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Barbara L. HEMPSTEAD, Rosemary KRAEMER, Shahin RAFII, Phi WIEGN, Michael J. DONOVAN
  • Patent number: 7328437
    Abstract: A technique to collectively manage locks by multiple virtual machines and then access shared data protected by the locks. A computer system defines first and second virtual machines and a memory shared by the first and second virtual machines. A lock structure is defined in the shared memory. The lock structure is capable of listing a holder of a lock for shared data in the shared memory. The first virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the first virtual machine accesses the shared data. The lock structure and the shared data are directly accessible by the first virtual machine. The second virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the second virtual machine accesses the shared data. The lock structure and shared data are directly accessible by the second virtual machine.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 5, 2008
    Assignee: International Business Machines Corporation
    Inventors: Michael J. Donovan, Melissa K. Howland, Steven Shultz, Xenia Tkatschow
  • Patent number: 7251815
    Abstract: A system, computer program product and method for dispatching work items in a virtual machine operating system. The virtual machine operating system defines first and second virtual machines. First and second work queues are created in a memory. The first virtual machine assigns a first work item to the first work queue and a second work item to the second work queue. The first virtual machine schedules work items from the first work queue for execution by the first virtual machine. The first and second work items originate from the first virtual machine. The first and second work queues are directly accessible by the first virtual machine. The second virtual machine assigns a third work item to the first work queue and a fourth work item to the second work queue. The second virtual machine schedules work items from the second work queue for execution by the second virtual machine. The third and fourth work items originate from the second virtual machine.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: July 31, 2007
    Assignee: International Business Machines Corporation
    Inventors: Michael J. Donovan, Melissa K. Howland, Steven Shultz, Xenia Tkatschow
  • Publication number: 20040230972
    Abstract: A technique to collectively manage locks by multiple virtual machines and then access shared data protected by the locks. A computer system defines first and second virtual machines and a memory shared by the first and second virtual machines. A lock structure is defined in the shared memory. The lock structure is capable of listing a holder of a lock for shared data in the shared memory. The first virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the first virtual machine accesses the shared data. The lock structure and the shared data are directly accessible by the first virtual machine. The second virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the second virtual machine accesses the shared data. The lock structure and shared data are directly accessible by the second virtual machine.
    Type: Application
    Filed: April 29, 2003
    Publication date: November 18, 2004
    Applicant: International Business Machines Corporation
    Inventors: Michael J. Donovan, Melissa K. Howland, Steven Shultz, Xenia Tkatschow
  • Publication number: 20040221285
    Abstract: A system, computer program product and method for dispatching work items in a virtual machine operating system. The virtual machine operating system defines first and second virtual machines. First and second work queues are created in a memory. The first virtual machine assigns a first work item to the first work queue and a second work item to the second work queue. The first virtual machine schedules work items from the first work queue for execution by the first virtual machine. The first and second work items originate from the first virtual machine. The first and second work queues are directly accessible by the first virtual machine. The second virtual machine assigns a third work item to the first work queue and a fourth work item to the second work queue. The second virtual machine schedules work items from the second work queue for execution by the second virtual machine. The third and fourth work items originate from the second virtual machine.
    Type: Application
    Filed: April 29, 2003
    Publication date: November 4, 2004
    Applicant: International Business Machines Corporation
    Inventors: Michael J. Donovan, Melissa K. Howland, Steven Shultz, Xenia Tkatschow
  • Publication number: 20030097668
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, advanced atherosclerosis/plaque rupture, ischemia/reperfusion, hypertension, restenosis, cardiac calcification, allo/xenograft valvular calcifications, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: February 8, 2002
    Publication date: May 22, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Katherine Galvin, Dean A. Falb, Michael J. Donovan, Dennis Huszar, Michael A. Gimbrone
  • Publication number: 20030078973
    Abstract: In a system and method for distributing transcript-synchronized video/audio records of legal proceedings, a server provides storage for video/audio records and corresponding transcripts. Server-side software synchronizes transcript and video/audio record so that each transcript line is synchronized to corresponding portion of the video/audio record, each transcript line containing a selectable link to the corresponding portion of the video/audio record. Members download record and transcript for review, selecting links to view desired portions of the record, adding page and line designations and annotations to the transcript, as desired. The annotated transcript is uploaded to the server, where separate iterations are tracked. Changes are distributed in real time, or merged and distributed at predetermined intervals. The server edits the video/audio record based on page and line designations, creating a corresponding sequence of video clips.
    Type: Application
    Filed: September 25, 2002
    Publication date: April 24, 2003
    Inventors: Michael V. Przekop, Kirk H. Knight, Michael J. Donovan
  • Patent number: 6359194
    Abstract: The present invention is based on the generation and phenotypic characterization of transgenic knockout homozygous rchd534 mutant mice which display characteristic cardiovascular disease symptoms. Such transgenic knockout homozygous rchd534 mutant mice are useful models for the analysis and characterization of rchd534 protein involvement in development and homeostasis of the cardiovascular system and tissue-specific regulation of the TGF-&bgr; signaling pathways. Such transgenic mice may be used for screening compounds that may potentially useful for treating or preventing cardiovascular disease.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: March 19, 2002
    Assignees: Millennium Pharmaceuticals, Inc., Brigham & Women's Hospital
    Inventors: Katherine Galvin, Dean A. Falb, Michael J. Donovan, Dennis Huszar, Michael A. Gimbrone, Jr.
  • Patent number: 6169268
    Abstract: A method and apparatus for forming constricted ends on tube products on an automatic continuous basis. The apparatus includes a feeding station including a spindle for supporting a metallic tube. A forming station is positioned downstream from the feeding station and includes a carriage supported for movement on a frame. A forming tool and a cutting tool are supported in spaced relation on the carriage. A welding unit, preferably a tungsten inert gas welder, is provided including a tip supported for movement with the carriage. The carriage is operably connected to a drive mechanism for driving the carriage in movement relative to the spindle. A controller is in communication with the drive mechanism for controlling movement of the carriage and is in further communication with the heat source for controlling activation thereof. A discharge conduit is supported on the carriage for discharging a plurality of successive formed tubes into a receiving bin.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: January 2, 2001
    Assignee: Esterline & Sons, Inc.
    Inventors: Dale F. Esterline, Michael J. Donovan