Abstract: A collapsible pet crate that is easy to operate, aesthetically pleasing, quiet, light, durable, easy to clean, and safe and comfortable for the animal. Also disclosed herein are methods of operating a collapsible pet crate. The collapsible pet crate disclosed herein can further include one-step operation, environmentally safe and pet-friendly materials, and method to include various pet-friendly accessories.

Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.

Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.

Abstract: The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.

Abstract: The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be detected simultaneously using between 8 and 82 probes for each nascent RNA. The invention comprises, in addition, methods of preparing a sample for nascent RNA detection by reducing autofluorescence of the tissue sample. These techniques may be synergistically combined to achieve significantly improved results.

Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.

Abstract: The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.

Abstract: A technique to collectively manage locks by multiple virtual machines and then access shared data protected by the locks. A computer system defines first and second virtual machines and a memory shared by the first and second virtual machines. A lock structure is defined in the shared memory. The lock structure is capable of listing a holder of a lock for shared data in the shared memory. The first virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the first virtual machine accesses the shared data. The lock structure and the shared data are directly accessible by the first virtual machine. The second virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the second virtual machine accesses the shared data. The lock structure and shared data are directly accessible by the second virtual machine.

Abstract: A system, computer program product and method for dispatching work items in a virtual machine operating system. The virtual machine operating system defines first and second virtual machines. First and second work queues are created in a memory. The first virtual machine assigns a first work item to the first work queue and a second work item to the second work queue. The first virtual machine schedules work items from the first work queue for execution by the first virtual machine. The first and second work items originate from the first virtual machine. The first and second work queues are directly accessible by the first virtual machine. The second virtual machine assigns a third work item to the first work queue and a fourth work item to the second work queue. The second virtual machine schedules work items from the second work queue for execution by the second virtual machine. The third and fourth work items originate from the second virtual machine.

Abstract: A technique to collectively manage locks by multiple virtual machines and then access shared data protected by the locks. A computer system defines first and second virtual machines and a memory shared by the first and second virtual machines. A lock structure is defined in the shared memory. The lock structure is capable of listing a holder of a lock for shared data in the shared memory. The first virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the first virtual machine accesses the shared data. The lock structure and the shared data are directly accessible by the first virtual machine. The second virtual machine acquires a lock for the shared data when available by manipulation of the lock structure. After acquiring the lock, the second virtual machine accesses the shared data. The lock structure and shared data are directly accessible by the second virtual machine.

Abstract: A system, computer program product and method for dispatching work items in a virtual machine operating system. The virtual machine operating system defines first and second virtual machines. First and second work queues are created in a memory. The first virtual machine assigns a first work item to the first work queue and a second work item to the second work queue. The first virtual machine schedules work items from the first work queue for execution by the first virtual machine. The first and second work items originate from the first virtual machine. The first and second work queues are directly accessible by the first virtual machine. The second virtual machine assigns a third work item to the first work queue and a fourth work item to the second work queue. The second virtual machine schedules work items from the second work queue for execution by the second virtual machine. The third and fourth work items originate from the second virtual machine.

Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, advanced atherosclerosis/plaque rupture, ischemia/reperfusion, hypertension, restenosis, cardiac calcification, allo/xenograft valvular calcifications, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

Abstract: In a system and method for distributing transcript-synchronized video/audio records of legal proceedings, a server provides storage for video/audio records and corresponding transcripts. Server-side software synchronizes transcript and video/audio record so that each transcript line is synchronized to corresponding portion of the video/audio record, each transcript line containing a selectable link to the corresponding portion of the video/audio record. Members download record and transcript for review, selecting links to view desired portions of the record, adding page and line designations and annotations to the transcript, as desired. The annotated transcript is uploaded to the server, where separate iterations are tracked. Changes are distributed in real time, or merged and distributed at predetermined intervals. The server edits the video/audio record based on page and line designations, creating a corresponding sequence of video clips.

Abstract: The present invention is based on the generation and phenotypic characterization of transgenic knockout homozygous rchd534 mutant mice which display characteristic cardiovascular disease symptoms. Such transgenic knockout homozygous rchd534 mutant mice are useful models for the analysis and characterization of rchd534 protein involvement in development and homeostasis of the cardiovascular system and tissue-specific regulation of the TGF-&bgr; signaling pathways. Such transgenic mice may be used for screening compounds that may potentially useful for treating or preventing cardiovascular disease.

Abstract: A method and apparatus for forming constricted ends on tube products on an automatic continuous basis. The apparatus includes a feeding station including a spindle for supporting a metallic tube. A forming station is positioned downstream from the feeding station and includes a carriage supported for movement on a frame. A forming tool and a cutting tool are supported in spaced relation on the carriage. A welding unit, preferably a tungsten inert gas welder, is provided including a tip supported for movement with the carriage. The carriage is operably connected to a drive mechanism for driving the carriage in movement relative to the spindle. A controller is in communication with the drive mechanism for controlling movement of the carriage and is in further communication with the heat source for controlling activation thereof. A discharge conduit is supported on the carriage for discharging a plurality of successive formed tubes into a receiving bin.