Abstract: Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.

Abstract: Compounds and methods of using the same for treating conditions alleviated by AMPK activation are provided.

Abstract: Disclosed herein are 15-hydroxyprostaglandin dehydrogenase inhibitor compounds. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are 15-hydroxyprostaglandin dehydrogenase inhibitor compounds, including variations of pyrrolopy-rimidines. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase.

Abstract: Provided herein are compounds, compositions, and methods for treating disorders (e.g., opioid addiction) using compounds disclosed herein, which are selective agonists of the cannabinoid 2 receptor (CB2R).

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.

Abstract: A hair iron having a first arm having a first free end, a first joint end, a first heating element and a first hair heating plate on an interior surface thereof proximate the first free end. The first heating element providing heat to the first hair heating plate. A second arm having a second free end, a second joint end, a second heating element and a second hair heating plate on an interior surface thereof proximate the second free end. The second heating element providing heat to the second hair heating plate. The first and second arms joined at the first and second join ends via a joint member such that the arms can be flexibly opened and closed to bring the first and second hair heating plates into and out of contact. A first removable, heat-resistant hair iron sheath, the first hair iron sheath configured to wrap around the first hair iron arm covering the first hair heating plate.

Abstract: A tailgate assembly includes a structure, and a handle assembly attached to the structure. The handle assembly is moveable relative to the structure between a stowed position, an intermediate position, and a deployed position. The handle assembly includes a connecting member that is attached to the structure. The connecting member is rotatable about a first axis relative to the structure. A handle portion is attached to the connecting member, and is rotatable about a second axis relative to the connecting member. The handle portion and the connecting member rotate in unison relative to the structure about the first axis, between the stowed position and the intermediate position, to position the handle portion outside an interior space of the structure. The handle portion rotates relative to the connecting member about the second axis, between the intermediate position and the deployed position, whereby a user may grasp the handle portion.

Abstract: A tailgate assembly includes a structure, and a handle assembly attached to the structure. The handle assembly is moveable relative to the structure between a stowed position, an intermediate position, and a deployed position. The handle assembly includes a connecting member that is attached to the structure. The connecting member is rotatable about a first axis relative to the structure. A handle portion is attached to the connecting member, and is rotatable about a second axis relative to the connecting member. The handle portion and the connecting member rotate in unison relative to the structure about the first axis, between the stowed position and the intermediate position, to position the handle portion outside an interior space of the structure. The handle portion rotates relative to the connecting member about the second axis, between the intermediate position and the deployed position, whereby a user may grasp the handle portion.

Abstract: An inner fender panel for a structural fender of an automotive vehicle is disclosed. The panel includes an outer surface configured for attachment to the inner surface of an outer panel of the fender and an inner surface; the inner panel comprising a plurality of abutting inner fender panel sections that are joined to one another, each inner fender panel section having a thickness, at least two abutting inner fender panel sections having thicknesses that are different. A structural fender for an automotive vehicle is also disclosed. The fender includes a formed outer panel having a viewable outer surface and an inner surface. The fender also includes a formed inner fender panel as described comprising a plurality of abutting inner fender panel sections that are joined to one another, each inner fender panel section having a thickness, at least two abutting inner fender panel sections having thicknesses that are different.

Abstract: A selectively detachable fender brace system includes a structural fender assembly comprising an outer fender panel comprising an outer upper attachment flange having a brace bore disposed therein and an inner fender panel comprising an inner upper attachment flange having a first blind slot extending inwardly toward an engine compartment and rearwardly to a first slot opening, the inner fender panel attached to the outer fender panel with the inner upper attachment flange disposed below the outer upper attachment flange and brace bore proximate the first blind slot; a brace comprising a fender end having a fender bore extending therethrough and an opposed wall end that is detachably attached to a cross-vehicle wall of the engine compartment; and a threaded fastener that is disposed through the brace bore, first blind slot and fender bore configured to apply a predetermined clamping force and forming a selectively detachable fender attachment joint.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: This invention is directed to bendable circuit substrate structures useful for LED mounting and interconnection.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: This invention is directed to bendable circuit substrate structures useful for LED mounting and interconnection.

Abstract: A selectively detachable fender brace system includes a structural fender assembly comprising an outer fender panel comprising an outer upper attachment flange having a brace bore disposed therein and an inner fender panel comprising an inner upper attachment flange having a first blind slot extending inwardly toward an engine compartment and rearwardly to a first slot opening, the inner fender panel attached to the outer fender panel with the inner upper attachment flange disposed below the outer upper attachment flange and brace bore proximate the first blind slot; a brace comprising a fender end having a fender bore extending therethrough and an opposed wall end that is detachably attached to a cross-vehicle wall of the engine compartment; and a threaded fastener that is disposed through the brace bore, first blind slot and fender bore configured to apply a predetermined clamping force and forming a selectively detachable fender attachment joint.