Abstract: There are disclosed deuterated 2C—X phenethylamine compounds. the use of such compounds in the treatment of diseases associated with a serotonin 5-HIT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds. methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

Abstract: Combination drag therapies comprising a 5-HTZA receptor agonist and an N-methyl-D-aspartate (NMDA) receptor antagonist (e.g., nitrous oxide, ketamine, etc.) are provided. Also described are pharmaceutical compositions and methods of treating a central nervous system (CNS) disorder or a psychiatric disease using the combination drug therapy, for example, via aerosol inhalation.

Abstract: There are disclosed deuterated 2C—X phenethylamine compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

Abstract: There are disclosed psychedelic and entactogen compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

Abstract: A door assembly includes a frame having interconnected wires that define an opening for an animal to pass therethrough, and a door having interconnected wires and being coupled to the frame. A latch assembly has a handle structure and a pin. The handle structure is pivotable with respect to one of the door and the frame, and the pin is movable axially with respect to one of the door and the frame. A first wire of the plurality of wires of the frame forms a key hole assembly. The key hole assembly defines an aperture for receiving the pin when the door is in a latched position with respect to the frame. A tab assembly is formed by at least one wire of the door and is disposable behind at least one of the plurality of wires of the frame in the closed position.

Abstract: A substrate for use in an aqueous slurry has a polymeric coating to provide a compliant and sticky surface. The polymer coating has a chemical to render the surface hydrophobic so as to attract hydrophobic or hydrophobized mineral particles in the slurry. The substrate can take the form of a conveyor belt, a bead, a mesh, an impeller, a filter or a flat surface. The substrate can also be an open-cell foam. The polymeric coating can be modified with tackifiers; plasticizers; crosslinking agents; chain transfer agents; chain extenders; adhesion promoters; aryl or alky copolymers; fluorinated copolymers and/or additives; hydrophobizing agents such as hexamethyldisilazane; inorganic particles such as silica, hydrophobic silica, and/or fumed hydrophobic silica; MQ resin; and/or other additives to control and modify the properties of the polymer.

Abstract: A process of coating an open-cell foam substrate includes the steps of arranging two rollers separated by a gap; positioning the substrate above the gap; providing a coating material onto the substrate, feeding the substrate through the gap so as to achieve a layer of the coating material on the substrate, wherein the coating material is selected from the group consisting of a polysiloxane derivative, acrylic polymer, butyl rubber, natural rubber, nitriles, styrene block copolymers with ethylene, styrene block copolymers with propylene, styrene block copolymers with isoprene and polyvinyl ether and modifying the coating with tackifiers; plasticizers; crosslinking agents; chain transfer agents; chain extenders; adhesion promoters; aryl or alky copolymers; fluorinated copolymers; hexamethyldisilazane; and silica.

Abstract: The present invention relates generally to diagnostic methods, systems, assays and kits for identification of subjects with cardiac amyloid deposits, where a low level of clusterin protein in a peripheral fluid sample, e.g., a serum sample from the subject, indicates the subject likely has cardiac amyloid deposits. Other aspects relate to methods of treatment of diseases or disorders characterized by cardiac amyloid deposits and transthyretin (TTR) amyloidosis, and more particularly to methods of treatment of cardiac-related amyloidosis and cardiac amyloid deposits in subjects with familial transthyretin (TTR), senile systemic amyloidosis (SSA), or familial amyloidodic polyneuropathy (FAP), or immunoglobulin light chain (AL) amyloidosis. Other aspects relate to methods and compositions comprising clusterin (CLU) or a clusterin agent (e.g.

Abstract: This invention relates to a process for preparing conditioned organic pigments by (a) milling a mixture comprising: (1) one or more crude organic pigments; (2) at least about 0.1% by weight, relative to the organic pigment, of one or more acrylic copolymer dispersants; and (3) 0 to about 100 parts by weight, relative to the organic pigment, of a milling liquid in which the organic pigment is substantially insoluble; and (b) isolating the milled organic pigment.

Abstract: This invention relates to a process for preparing perylene pigment compositions by (a) reacting, at a temperature of less than about 25° C., a mixture of (1) a perylene tetracarboxylic compound, (2) at least about 0.1% by weight, relative to the perylene tetracarboxylic compound, of a surfactant of formula (I)  wherein R1, R2, R3, X, Y, Z, and Z′ are defined herein, (3) an equivalent excess, relative to the amount of the perylene tetracarboxylic compound, of ammonia or a primary amine RA—NH2, wherein RA is defined herein, and (4) optionally, a solvent,  to form a perylene intermediate; (b) heating the perylene intermediate at a temperature of about 50° C. to about 250° C., optionally in the presence of certain non-pigmentary cyclic anhydrides or imides and/or solvents; and (c) collecting the perylene pigment composition.

Abstract: This invention relates to a process for preparing conditioned organic pigments by

Abstract: This invention relates to a process for preparing perylene pigment compositions by reaction of (a) a perylene tetracarboxylic compound; (b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) wherein W is O or NR1 (where R1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R2, R3, and R4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R2−C=C—R3; (c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of (d) a solvent and/or (e) one or more dispersants.

Abstract: This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.

Abstract: This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR' (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.

Abstract: This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.

Abstract: This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 or R.sup.3 --C.dbd.C--R.sup.4 ; and(c) ammonia or a primary alkyl, aralkyl, or aryl amine;optionally in the presence of(d) a solvent and/or(e) one or more dispersants.

Abstract: This invention relates to a process for preparing pigment compositions by(a) treating an organic pigment with(1) a sterically hindered and/or bulky primary amine, and(2) a liquid in which the organic pigment is insoluble, and(b) blending the resultant surface-treated pigment composition from step (a) with a pigment derivative of formula (I) ##STR1## wherein Q represents an organic pigment moiety,X is O, S, NR.sup.1, --SO.sub.2 --, --CO--, --Alk--, --Ar--, or combinations thereof,Y is --OR.sup.2, --NR.sup.3 R.sup.4, or Het,Alk is C.sub.1 -C.sub.5 alkylene, C.sub.2 -C.sub.5 alkenylene, or C.sub.4 -C.sub.5 alkadienylene, or substituted derivatives thereof,Ar is arylene,R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.16 aralkyl, or C.sub.6 -C.sub.10 aryl,Het is a heterocycle, andn is 1 to 4.

Abstract: This invention relates to water-dispersible phthalocyanine pigment formulations that are mixtures of(a) about 60 to about 99.5% by weight, based on the total amount of components (a) and (b), of a conditioned metal phthalocyanine pigment, and(b) about 0.5 to about 40% by weight, based on the total amount of components (a) and (b), of a water-insoluble sulfonated phthalocyanine having the formulaPc(SO.sub.2 OR).sub.x (I)whereinPc represents a phthalocyanine moiety;R is H or M, wherein M is a monovalent metal, divalent metal, trivalent metal, or ammonium cation, andx is a from about 0.2 to about 4.

Abstract: This invention relates to a process for the preparation of quinacridone pigments by(a) heating, at a temperature of about 80.degree. C. to about 145.degree. C., a reaction mixture containing(i) 2,5-dianilinoterephthalic acid, a 2,5-dianilino-3,6-dihydroterephthalic acid ester, and/or a derivative thereof,(ii) about 3 to about 15 parts by weight, per part of component (a)(i), of a dehydrating agent, and(iii) about 0.

Abstract: This invention relates to a process for the preparation of quinacridone pigments comprising(a) heating, at a temperature of about 80.degree. C. to about 145.degree. C., a reaction mixture comprising(i) 2,5-dianilinoterephthalic acid or a 2,5-dianilinoterephthalic acid derivative having one or more substituents in at least one aniline ring,(ii) about 2 to about 10 parts by weight, relative to component (a)(i), of a dehydrating agent, and(iii) about 0.01 to about 10 percent by weight, relative to component (a)(i), of a salt other than an iron salt;(b) drowning the reaction mixture from step (a) by adding said reaction mixture to about 3 to about 15 parts by weight, relative to component (a)(i), of a liquid in which the pigment is substantially insoluble;(c) isolating the quinacridone pigment; and(d) optionally, conditioning the quinacridone pigment.