Patents by Inventor Michael J. Greig

Michael J. Greig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analytical method for protein mapping using hydrogen/deuterium exchange
    Patent number: 7960179
    Abstract: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a deuterium; (c) separating the peptide or protein with supercritical fluid chromatography; and (d) analyzing by mass spectrometry the mass of the separated peptide or protein. Supercritical fluid chromatography enables the observation of fast exchanging hydrogen atoms missed using conventional liquid chromatography methods.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: June 14, 2011
    Assignee: Florida State University Research Foundation
    Inventors: Mark R. Emmett, Sasa Kazazic, Alan G. Marshall, Michael J. Greig
  • Analytical Method for Protein Mapping Using Hydrogen/Deuterium Exchange
    Publication number: 20100112621
    Abstract: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a deuterium; (c) separating the peptide or protein with supercritical fluid chromatography; and (d) analyzing by mass spectrometry the mass of the separated peptide or protein. Supercritical fluid chromatography enables the observation of fast exchanging hydrogen atoms missed using conventional liquid chromatography methods.
    Type: Application
    Filed: October 12, 2009
    Publication date: May 6, 2010
    Applicant: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mark R. Emmett, Sasa Kazazic, Alan G. Marshall, Michael J. Greig
  • Analytical method for protein mapping using hydrogen/deuterium exchange
    Patent number: 7601542
    Abstract: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a deuterium; (c) separating the peptide or protein with supercritical fluid chromatography; and (d) analyzing by mass spectrometry the mass of the separated peptide or protein. Supercritical fluid chromatography enables the observation of fast exchanging hydrogen atoms missed using conventional liquid chromatography methods.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: October 13, 2009
    Assignee: Florida State University Research Foundation
    Inventors: Mark R. Emmett, Sasa Kazazic, Alan G. Marshall, Michael J. Greig