Patents by Inventor Michael J Guiliani

Michael J Guiliani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gastric retentive extended release pharmaceutical compositions
    Patent number: 8741885
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 3, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Krishna Devarakonda, Michael J Guiliani, Vishal K Gupta, Ralph A Heasley, Susan Shelby
  • Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
    Patent number: 8658631
    Abstract: The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: February 25, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Krishna Devarakonda, Michael J Guiliani, Vishal K Gupta, Ralph A Heasley, Susan Shelby