Abstract: An apparatus for aseptically filling premanufactured, presterilized, flexible containers, connected in a continuous web, includes a chamber with an inlet mouth for receiving empty containers seriatim, and an outlet mouth for dispensing filled containers seriatim. The inlet and outlet mouths have respective seals for sealing to the surface of the containers to prevent entry of contaminants into the chamber. This chamber is partitioned to form a spraying compartment, adjacent to the inlet mouth, and a filling compartment, adjacent to the outlet mouth, with a drying compartment therebetween. A sterilizing agent is continuously sprayed, as a mist, into the spraying compartment to coat the exterior of the containers with the sterilizing agent as they are serially advanced through the chamber. This mist also provides an aseptic barrier between the inlet mouth and the drying compartment.