Patents by Inventor Michael J. Janusz

Michael J. Janusz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
    Patent number: 6953788
    Abstract: The present invention relates to certain novel 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: October 11, 2005
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Joseph T. Tsay, Michael J. Janusz, Jian Shen, Gary A. Flynn, Ramalinga M. Dharanipragada, Joseph P. Burkhart, Douglas W. Beight, Meena V. Patel
  • 1-Carboxylmethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12
    Patent number: 6770640
    Abstract: The present invention relates to certain novel 1-carboxymethyl-2-oxo-azepan derivatives of the formula useful as inhibitors of matrix metalloproteinases (MMPs). The compounds of formula (1) are especially useful as selective inhibitors of MMP-12. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: August 3, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Michael J. Janusz
  • N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
    Patent number: 6544980
    Abstract: The present invention provides a method of inhibiting matrix metallo-proteinases (MMPs) in a patient in need thereof comprising administering to the patient an effective matrix metalloproteinase inhibiting amount of the N-carboxymethyl substituted benzolactams of formula (1): wherein A is —OH or —NRR′. Such inhibitors are useful in treating neoplasms, atherosclorosis, and chronic inflammatory diseases. The present invention also provides novel N-carboxymethyl substituted benzolactams of formula (1a): wherein A is —NRR′.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: April 8, 2003
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Michael J. Janusz, Gary A. Flynn
  • N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
    Publication number: 20020095035
    Abstract: The present invention provides a method of inhibiting matrix metallo-proteinases (MMPs) in a patient in need thereof comprising administering to the patient an effective matrix metalloproteinase inhibiting amount of the N-carboxymethyl substituted benzolactams of formula (1): 1
    Type: Application
    Filed: February 20, 2002
    Publication date: July 18, 2002
    Inventors: Alan M. Warshawsky, Michael J. Janusz, Gary A. Flynn
  • Selective inhibitors of MMP-12
    Patent number: 6352976
    Abstract: The present invention provides novel mercaptoacetylamido dipeptide carboxylic acids of the formula which are MMP inhibitors useful for the treatment of smoking-induced emphysema.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: March 5, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Michael J. Janusz
  • Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase
    Patent number: 6329550
    Abstract: The present application relates to novel aminomalonamides of the formula and pharmaceutical composition thereof which are useful for inhibiting matrix metalloproteinases.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: December 11, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Michael J. Janusz
  • 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
    Patent number: 6262080
    Abstract: The present invention provides novel thio-substitutedamido lactam derivatives of the formula useful in as inhibitors of matrix metallo-proteinases (MMPs).
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: July 17, 2001
    Assignee: Avantis Pharmaceuticals Inc.
    Inventors: Alan M. Warshawsky, Michael J. Janusz
  • Inhibitors of Cathepsin G and elastase for preventing connective tissue degradation
    Patent number: 5510333
    Abstract: Novel compounds which are chemically linked inhibitors of the proteases Elastase and Cathepsin G prevent connective tissue degradation associated with neutrophil induced inflammatory disease.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 23, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Philippe Bey, Niall S. Doherty, Michael J. Janusz, Shujaath Mehdi, Norton P. Peet
  • Method of preventing neutrophil mediated connective tissue damage
    Patent number: 5384119
    Abstract: Oligomers of the formula ##STR1## have demonstrated effectiveness in preventing connective tissue damage.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: January 24, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Michael J. Janusz
  • Derivativized polysaccharides with biologic activity, method of their isolation, and uses therefor
    Patent number: 5057503
    Abstract: This invention relates to the discovery and isolation of the smallest biologically active polysaccharide which will interact with the .beta.-glucan receptors present on mammalian phagocytic cells. The invention additionally relates to methods of preparing this heptaglucoside, and uses of the molecule as an immunomodulator and an activating agent. The invention additionally relates to methods of separating biologically active polysaccharides from similar inactive forms, and improved methods of separating low molecular weight polysaccharides and isomers from one another.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: October 15, 1991
    Assignee: The Brigham and Women's Hospital
    Inventors: Joyce K. Czop, Michael J. Janusz
  • Set of game playing pieces
    Patent number: D270171
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: August 16, 1983
    Inventor: Michael J. Janusz