Patents by Inventor Michael J. Kaufman

Michael J. Kaufman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20010049439
    Abstract: There is disclosed 3-(5-methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine in the form of a dihydrate, a dehydrate of the dihydrate and a pentahydrate, pharmaceutical compositions comprising the forms, the use of the forms for enhancing cognition, processes for producing the forms, their incorporation in pharmaceutical compositions comprising pamoate ions and the use of such ions for solubilizing neutral molecules.
    Type: Application
    Filed: November 30, 2000
    Publication date: December 6, 2001
    Applicant: Merck & Co., Inc.
    Inventors: Michael J. Kaufman, James A. McCauley, Daniel J. Rush, David M. Tschaen, Richard J. Varsolona, Guo-Jie Ho
  • Patent number: 6297231
    Abstract: The present invention relates to a novel stabilized form of carbapenem antibiotics of formula II: compositions and methods thereof wherein the antibiotics and compositions are stabilized degradation and dimer formation. The compounds can be used in the treatment of infectious diseases, including gram positive and negative, aerobic and anaerobic bacteria. The compounds provide good stability against beta-lactamases, and a favorable duration of action. The compounds of this invention are represented structural formula I: or a pharmaceutically acceptable or hydrate thereof.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: October 2, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Orn Almarsson, Michael J. Kaufman, John D. Stong, John M. Williams
  • Patent number: 6136783
    Abstract: The invention is a pharmaceutical composition for intravenous administration to a patient comprisinga) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; andc) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: October 24, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Maneesh J. Neururkar, Michael J. Kaufman, William A. Hunke
  • Patent number: 6029688
    Abstract: The invention is a water wheel supplying energy to a pump. The pump will typically be used to apply chemical treatments to the water stream. Some examples of chemicals to be added are acids or bases to bring the pH to an acceptable level, precipitation aids for suspending metal out of water, coagulants to aid in filtering dissolved solids out of water, flocculants to aid in filtering dissolved ions out of water, chlorine, or coloring to prevent growth of algae.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: February 29, 2000
    Inventor: Michael J. Kaufman
  • Patent number: 5952323
    Abstract: A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: September 14, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Jeffrey A. Zimmerman, John M. Williams, Paul A. Bergquist, Lisa M. DiMichele, David C. DuBost, Michael J. Kaufman, Daniel R. Sidler, William A. Hunke
  • Patent number: 5952300
    Abstract: The invention is a pharmaceutical composition for intravenous administration to a patient comprisinga) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; andc) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 14, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Maneesh J. Nerurkar, William A. Hunke, Michael J. Kaufman
  • Patent number: 5887241
    Abstract: A method for shaping a consolidated, substantially oxygen-free, equiaxed MoSi.sub.2 /SiC composite body having an average grain size of 10 .mu.m or less, a SiC content of 2 to 60 v/o and relatively low strength and relatively high ductility comprising subjecting the composite body to plastic deformation under conditions of forming temperature and rate of deformation such that grain growth is substantially avoided, the MoSi.sub.2 /SiC composite body being obtained by providing particles of molybdenum, silicon and carbon in a proportion relative to each other required to produce a composite powder of MoSi.sub.2 and SiC having a composition in that segment of the ternary diagram of FIG. 1 designated A, and subjecting the particles to mechanical alloying under conditions and for a time sufficient to produce the composite powder, followed by consolidation of the composite powder.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: March 23, 1999
    Assignee: University of Florida
    Inventors: S. Jayashankar, Kyung-Tae Hong, Michael J. Kaufman
  • Patent number: 5767124
    Abstract: This invention is concerned with polymorphic forms of the compound N-?1(R)-?(1,2-dihydro-1-methanesulfonylspiro?3H-indole-3,4'-piperdin!-1'-y l)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-?1(R)-?(1,2-dihydro-1-methanesulfonylspiro?3H-indole-3,4'-piperdin!-1'-y l)carbonyl!-2-(phenylmethyloxy)-ethyl!-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: June 16, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerome P. Draper, Michael J. Kaufman, David C. Dubost, James A. McCauley, Jennifer L. Vandrilla, Richard J. Varsolona
  • Patent number: 5640666
    Abstract: A method of producing a composite powder by providing particles of (I) tungsten, niobium, zirconium, titanium or mixtures thereof, (II) silicon and (III) carbon in a proportion relative to each other so as to possess an overall chemical composition in that segment of the ternary diagram of FIGS. 2(a), 2(b), 2(c) and 2(d) designated A, and subjecting the particles to a mechanical alloying process under conditions and for a time sufficient to produce the composite powder. Also disclosed is a method of forming a substantially oxygen-free composition of matter comprising a matrix substance of WSi.sub.2, NbSi.sub.2, ZrSi.sub.2, TiSi.sub.2 or alloys thereof having SiC dispersed therein, the method comprising consolidating the above-described composite powder. Also disclosed is a method of forming oxidation- and wear-resistant coatings by subjecting the composite powder whose composition lies in segment A to a metallurgical process such as plasma spraying.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: June 17, 1997
    Assignee: University of Florida
    Inventors: S. Jayashankar, Michael J. Kaufman
  • Patent number: 5535688
    Abstract: An apparatus for adapting a tool bar planting system to the front of an agricultural combine. The tool bar is secured to the front framework of the combine after the grain head has been removed. The tool bar includes folding extension arms that allow for various planting and transporting configurations. Planter seed units are attached to the tool bar and the extension units to complete the planting system. Seeds for the planter seed units are stored in the grain storage bin on the combine and delivered to the individual planter seed units by an air conveying system.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: July 16, 1996
    Inventor: Michael J. Kaufman
  • Patent number: 5457107
    Abstract: This invention is concerned with a novel polymorphic form of the compound 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo )methyl)-3-(S)-phenyl-morpholine which is a tachykinin receptor antagonist useful in the treatment of inflammatory diseases, pain or migraine, asthma, and emesis.The instant polymorphic form has advantages over the other known forms of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo )methyl)-3-(S)-phenyl-morpholine in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: October 10, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Michael J. Kaufman
  • Patent number: 5454999
    Abstract: A method of producing a composite powder by providing particles of, e.g., molybdenum, silicon and carbon, in a proportion relative to each other so as to possess an overall chemical composition in that segment of the ternary diagram of FIG. 1 designated A, and subjecting the particles to a mechanical alloying process under conditions and for a time sufficient to produce the composite powder. Also disclosed is a method of forming a substantially silica-free composition of matter comprising a matrix substance of MoSi.sub.2 having SiC dispersed therein, the method comprising consolidating the above-described composite powder. Also disclosed is a method of forming oxidation- and wear-resistant coatings by subjecting the composite powder whose composition lies in segment A to a metallurgical process such as plasma spraying. A method of forming a composite material of uniformly dispersed particles of silicon carbide in a silicide or an alloy silicide matrix, particularly molybdenum disilicide, is also disclosed.
    Type: Grant
    Filed: June 1, 1993
    Date of Patent: October 3, 1995
    Assignee: University of Florida
    Inventors: S. Jayashankar, Michael J. Kaufman
  • Patent number: 5340531
    Abstract: A method for producing a substantially silica-free composition of matter comprising a matrix of MoSi.sub.2 having SiC dispersed therein, the matrix being reinforced with a particulate ductile refractory metal, the method comprising providing a composite of the particulate ductile refractory metal and a substantially silica-free composite mechanical alloy powder comprising MoSi.sub.2 and SiC having a composition in that segment of the ternary diagram of FIG. 1 designated A, and consolidating the composite of particulate ductile refractory metal and mechanical alloy powder; the coefficient of thermal expansion of the MoSi.sub.2 matrix having SiC dispersed therein being substantially equivalent to that of the particulate ductile refractory metal. The composition of matter formed by the method and an article of manufacture comprising the same are also disclosed.
    Type: Grant
    Filed: June 1, 1993
    Date of Patent: August 23, 1994
    Assignee: University of Florida
    Inventors: S. Jayashankar, Michael J. Kaufman
  • Patent number: 4243136
    Abstract: A pump for spraying an anti-freezing liquid on a conveyor belt exposed to freezing temperatures is controlled by an electric circuit containing a timer, a relay provided with a normally open switch, and a normally open thermostat that closes to start the timer when the ambient temperature falls below a given low temperature. The relay is connected in series with the timer switch and the thermostat to close the relay switch when both the timer switch and the thermostat are closed, whereby the pump will be operated until the timer times out or the thermostat reopens. If desired, the relay can be omitted.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: January 6, 1981
    Inventor: Michael J. Kaufman