Patents by Inventor Michael J. Keating
Michael J. Keating has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7943332Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: GrantFiled: April 16, 2010Date of Patent: May 17, 2011Assignee: Board of Regents, the University of Texas SystemInventors: Maher Albitar, Michael J. Keating, Taghi Manshouri
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Patent number: 7816628Abstract: In an embodiment of the present invention, a garment includes a fabric having a channel, a heat conductive wire disposed in the channel, a power source coupled to the heat conductive wire and detachably attached to the garment, and a controller electrically coupled to the power source and detachably attached to the garment, wherein the controller is configured with a heat setting. In another embodiment of the present invention, a method of heating a garment includes providing a fabric, forming a channel, disposing a heat conductive wire within the channel, connecting the heat conductive wire with a power source, wherein the power source is a rechargeable battery, and adjusting the heating of the garment by operating the power source and the heat conductive wire using a controller.Type: GrantFiled: November 22, 2006Date of Patent: October 19, 2010Assignee: Products of Tomorrow, Inc.Inventors: Juan Fernandez, Paul McGrath, Frank Cipolla, James Sabastian, Michael J. Keating
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Publication number: 20100221761Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: ApplicationFiled: April 16, 2010Publication date: September 2, 2010Applicant: The Board of Regents of the University of Texas SystemInventors: Maher Albitar, Michael J. Keating, Taghi Manshouri
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Publication number: 20100174343Abstract: Electrode systems and methods are provided for applying electrical stimulation to a wound or skin. The electrode systems may include a feedback sensor configured to detect at least one wound healing factor or other treatment factors and may adjust the electrical stimulation based on feedback sensor measurements. The electrode systems may include multiple center electrodes for attachment to the wound. Multiple therapies may be stored on the electrode systems and a selected one of the stored therapies may be applied. A timer may be included to indicate the length of time a therapy has been applied. The electrode system may include a control module configured as a flexible circuit which conforms to the shape of the wound or the skin to which it is applied. In addition, a medical kit may be supplied for use in applying therapies, including multiple control modules and multiple electrodes.Type: ApplicationFiled: August 7, 2009Publication date: July 8, 2010Applicant: Biofisica LLCInventors: Rafael Victor Andino, Christopher J. Brooks, Michael J. Keating, Courtney F. Morgan, Donald Van Royen
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Patent number: 7718387Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: GrantFiled: September 20, 2002Date of Patent: May 18, 2010Assignee: Board of Regents, the University of Texas SystemInventors: Maher Albitar, Michael J. Keating, Taghi Manshouri
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Publication number: 20100063747Abstract: The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.Type: ApplicationFiled: October 21, 2009Publication date: March 11, 2010Inventors: Maher Albitar, Elihu H. Estey, Hagop M. Kantarjian, Francis J. Giles, Michael J. Keating
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Patent number: 7627381Abstract: A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.Type: GrantFiled: February 3, 2005Date of Patent: December 1, 2009Assignee: Therm Med, LLCInventors: John Kanzius, William Harry Steinbrink, Robert J. McDonald, Michael J. Keating
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Patent number: 7622306Abstract: The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.Type: GrantFiled: April 20, 2005Date of Patent: November 24, 2009Assignee: Board of Regents, The University of Texas SystemInventors: Maher Albitar, Elihu H. Estey, Hagop M. Kantarjian, Francis J. Giles, Michael J. Keating
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Publication number: 20090109461Abstract: A lightweight, battery operated, portable, personal electronic device capable of faxing, scanning, printing and copying media as a standalone device or in cooperation with other electronic devices including PCs, mobile telephones, PDAs, etc. is provided. The device automatically detects the presence of fax-capable devices and reconfigures the software for compatibility with the fax-capable device eliminating the need for user programming. The device's ergonomic design, intrinsic physical stability, and same side paper feeds and user interface provide use in work areas having limited space. The device includes unidirectional, independent pathways for original and recording media such that paper jams are minimized. Portability is maximized through innovative power management software and hardware.Type: ApplicationFiled: October 27, 2008Publication date: April 30, 2009Inventors: Mario Moreno, Robert Cichielo, Michael J. Keating
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Patent number: 7443547Abstract: A lightweight, battery operated, portable, personal electronic device capable of faxing, scanning, printing and copying media as a standalone device or in cooperation with other electronic devices including PCs, mobile telephones, PDAs, etc. is provided. The device automatically detects the presence of fax-capable devices and reconfigures the software for compatibility with the fax-capable device eliminating the need for user programming. The device's ergonomic design, intrinsic physical stability, and same side paper feeds and user interface provide use in work areas having limited space. The device includes unidirectional, independent pathways for original and recording media such that paper jams are minimized. Portability is maximized through innovative power management software and hardware.Type: GrantFiled: July 3, 2004Date of Patent: October 28, 2008Assignee: Science Forge, Inc.Inventors: Mario Moreno, Robert Cichielo, Michael J. Keating
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Publication number: 20080116189Abstract: In an embodiment of the present invention, a garment includes a fabric having a channel, a heat conductive wire disposed in the channel, a power source coupled to the heat conductive wire and detachably attached to the garment, and a controller electrically coupled to the power source and detachably attached to the garment, wherein the controller is configured with a heat setting.Type: ApplicationFiled: November 22, 2006Publication date: May 22, 2008Applicant: Products of Tomorrow, Inc.Inventors: Juan Fernandez, Paul McGrath, Frank Cipolla, James Sabastian, Michael J. Keating
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Publication number: 20080027509Abstract: Electrode systems and methods are provided for applying electrical stimulation to a wound or skin. The electrode systems may include a feedback sensor configured to detect at least one wound healing factor or other treatment factors and may adjust the electrical stimulation based on feedback sensor measurements. The electrode systems may include multiple center electrodes for attachment to the wound. Multiple therapies may be stored on the electrode systems and a selected one of the stored therapies may be applied. A timer may be included to indicate the length of time a therapy has been applied. The electrode system may include a control module configured as a flexible circuit which conforms to the shape of the wound or the skin to which it is applied. In addition, a medical kit may be supplied for use in applying therapies, including multiple control modules and multiple electrodes.Type: ApplicationFiled: July 28, 2006Publication date: January 31, 2008Applicant: Biofisica LLCInventors: Rafael Victor Andino, Christopher J. Brooks, Michael J. Keating, Courtney F. Morgan, Donald Van Royen
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Patent number: 7309247Abstract: A connection device comprises first and second connectors. The first connector has a sleeve having axially extending slots at a distal end to define tines yieldable resiliently inward, and a resilient seal encircling the sleeve proximally of the slots. The second connector has a shroud dimensioned to receive the distal end of the first connector sleeve within the shroud and to engage the first connector resilient seal when the sleeve is fully received within the shroud.Type: GrantFiled: May 23, 2006Date of Patent: December 18, 2007Assignee: Micro-CoaxInventor: Michael J. Keating
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Patent number: 6914555Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.Type: GrantFiled: May 1, 2003Date of Patent: July 5, 2005Assignee: Gen-Probe IncorporatedInventors: James H. Lipscomb, Anna Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski, Larry Jurik
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Patent number: 6851453Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.Type: GrantFiled: April 30, 2003Date of Patent: February 8, 2005Assignee: Gen-Probe IncorporatedInventors: James H. Lipscomb, Anna Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski, Larry Jurik
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Patent number: 6663353Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.Type: GrantFiled: August 8, 2002Date of Patent: December 16, 2003Assignee: Gen-Probe IncorporatedInventors: James H. Lipscomb, Larry Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski
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Patent number: 6658946Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant device for detecting fluid flow through the conduit.Type: GrantFiled: August 8, 2002Date of Patent: December 9, 2003Assignee: Gen-Probe IncorporatedInventors: James H. Lipscomb, Larry Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski
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Publication number: 20030209093Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.Type: ApplicationFiled: April 30, 2003Publication date: November 13, 2003Inventors: James H. Lipscomb, Larry Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski, Anna Jurik
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Publication number: 20030200801Abstract: A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.Type: ApplicationFiled: May 1, 2003Publication date: October 30, 2003Inventors: James H. Lipscomb, Larry Jurik, Bernard Katz, Michael J. Keating, Stone Klengler, John J. Kotlarik, Mieczyslaw Wroblewski, Anna Jurik
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Patent number: D532372Type: GrantFiled: December 7, 2005Date of Patent: November 21, 2006Assignee: Voxred International, LLC.Inventor: Michael J. Keating