Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: Methods and composition are provided for deriving cement and/or supplementary cementitious materials, such as pozzolans, from one or more non-limestone materials, such as one or more non-limestone rocks and/or minerals. The non-limestone materials, e.g., non-limestone rocks and/or minerals, are processed in a manner that a desired product, e.g., cement and/or supplementary cementitious material, is produced.

Abstract: A method of validating a regulated application by generating, on a local data processing system, an automated agent to oversee a validation process of the regulated application on the local data processing system regardless of a local or web-based nature of the regulated application.

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: A system and method includes reception of first two-dimensional projection images of a patient volume, each of the first two-dimensional projection images having been acquired from substantially a respective one of a plurality of projection angles during presence of at least a portion of contrast medium in arteries within the patient volume, reception of second two-dimensional projection images of the patient volume, each of the second two-dimensional projection images having been acquired from substantially a respective one of the plurality of projection angles during presence of at least a portion of the contrast medium in veins within the patient volume, generation, for each of the plurality of projection angles, of a composite two-dimensional image based on one of the first two-dimensional projection images acquired from substantially the projection angle and one of the second two-dimensional projection images acquired from substantially the projection angle, generation of a three-dimensional image based

Abstract: A system and method includes reception of first two-dimensional projection images of a patient volume, each of the first two-dimensional projection images having been acquired from substantially a respective one of a plurality of projection angles during presence of at least a portion of contrast medium in arteries within the patient volume, reception of second two-dimensional projection images of the patient volume, each of the second two-dimensional projection images having been acquired from substantially a respective one of the plurality of projection angles during presence of at least a portion of the contrast medium in veins within the patient volume, generation, for each of the plurality of projection angles, of a composite two-dimensional image based on one of the first two-dimensional projection images acquired from substantially the projection angle and one of the second two-dimensional projection images acquired from substantially the projection angle, generation of a three-dimensional image based

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: Systems and methods for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: A toilet flushing assembly (500) comprising an actuating device (600) installable within the toilet tank (200) and an initiating device (700) accessible from outside the toilet tank (200). The flush-actuating device (600) comprises an electric motor (610) that converts a passageway (620) between a rest condition and a flush condition. The flush-initiating device (700) initiates operation of the flush-actuating device (600), preferably in either a light-flush mode or heavy-flush mode, depending upon the deposit made in the toilet bowl.

Abstract: End-diastolic and end-systolic image frames are automatically selected on a real-time basis from a sequence of X-ray ventricular angiogram images by modeling the angiogram images by a dynamic graphical model and estimating a posterior probability density of the ventricular area in each angiogram image frame using Bayesian probability density propagation and adaptive background modeling. Then, a variation curve plot of expectation values of the posterior probability density of the ventricular area of each angiogram image frame is generated in which peaks and valleys in the variation curve correspond to end-diastolic and end-systolic angiogram image frames, respectively.

Abstract: A system uses integrated spatio-temporal analysis in X-ray angiography, for example, by using spatial information within each image frame and temporal information between image frames to provide robust and accurate estimation of stroke area and volume, two and three dimensional ejection fraction and to accommodate patient heart variation. A system determines patient heart related parameters for use in patient heart imaging examination. An image data processor processes data representing multiple cardiac images of a patient over multiple heart beat cycles of the patient to derive data representing a distribution curve of a heart section area over multiple heart beat cycle times and indicating heart section area change over a heart beat cycle. An area processor determines a heart section area in response to user command. Also a computation processor determines a heart function parameter in response to the determined heart section area and the indicated heart section area change.

Abstract: End-diastolic and end-systolic image frames are automatically selected on a real-time basis from a sequence of X-ray ventricular angiogram images by modeling the angiogram images by a dynamic graphical model and estimating a posterior probability density of the ventricular area in each angiogram image frame using Bayesian probability density propagation and adaptive background modeling. Then, a variation curve plot of expectation values of the posterior probability density of the ventricular area of each angiogram image frame is generated in which peaks and valleys in the variation curve correspond to end-diastolic and end-systolic angiogram image frames, respectively.