Patents by Inventor Michael J Leach

Michael J Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmacologically active CNS compounds
    Patent number: 5635507
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael J. Leach
  • Treatment of injury of the spinal cord or brain using 4-amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine
    Patent number: 5597827
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael J. Leach
  • Certain 2,4-diamino-5-(2,3-dihalophenyl)-6-substituted pyrimidines which are pharmacologically active CNS compounds
    Patent number: 5597828
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael J. Leach
  • Treatment of damage from a stroke using 4-amino(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine
    Patent number: 5591746
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 7, 1997
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael J. Leach
  • Certain 2,4-diamino-5-(2,3,5-TRI-chlorophenyl)-6-substituted-pyrimidines which are pharmacologically active CNS compounds
    Patent number: 5587380
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 24, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael J. Leach
  • Phase-on ride-through control circuit
    Patent number: 4459652
    Abstract: A D.C. power supply (10, 44) having an auxiliary bridge rectifier (14, 38, 48) connected in series with a primary bridge rectifier (12, 46) is disclosed. The auxiliary bridge rectifier (14, 38, 48) "floats" above the potential of the primary bridge rectifier (12, 46) furnishing additional voltage at the D.C. power supply output (20, 22; 56, 58) whenever the A.C. mains voltage input to the main bridge rectifier (12, 46) drops below a predetermined value. In one embodiment of the present invention, a series of SCR's (26, 28) arranged in three-phase configuration perform the rectification and regulation functions of the primary bridge rectifier (12, 46) and the auxiliary bridge rectifier (14, 48). In an alternate embodiment of the present invention, paired SCR's (40) and diodes (42) are arranged in a half-controlled auxiliary bridge rectifier configuration (38). Individual firing angles for the various SCR's (26, 28, 40) are computed as a composite of several factors, including a firing delay factor .alpha..sub.
    Type: Grant
    Filed: February 16, 1982
    Date of Patent: July 10, 1984
    Assignee: Emerson Electric Company
    Inventors: Maurice James, Michael J. Leach, Stephen J. Mackay