Abstract: Systems and methods are provided for segmenting time-series data stored in data segments containing one or more data records. A combined segment error measure is determined based on a proposed combination of two candidate segments. An error cost to merge the two candidate segments is determined based on a difference between the combined segment error measure and a segment error measure of one of the segments. The two candidate segments are combined when the error cost to merge meets a merge threshold to generate a combined segment.

Abstract: An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure.

Abstract: Various technologies and techniques are disclosed for enhancing security in a browser-based environment. A first browser application hosts one or more other applications. The first browser application is operable to load the one or more other applications on one or more separate domains than a host domain, using one or more cookies as a communication method between the first browser application and the one or more other applications. Input is received from a user to access a first browser application on a first domain. A selection is received from the user to run a second browser application from within the first browser application. A first cookie is created in a second domain, with the first cookie containing information to be used by the second browser application. The second browser application is loaded on the second domain. For example, the first browser application can be a browser-based software development application.

Abstract: Computer-implemented systems and methods are provided for implementing a scenario analysis manager that performs multiple scenarios based upon time series data that is representative of transactional data are provided. A system and method provides candidate predictive models for a first scenario for selection where the set of candidate predictive models includes an identification of variables associated with a model. Model selection data is received from a scenario analysis manager where a selected model is configured to predict a future value of a first variable based on values of a second variable. Time series data is received representative of past transaction activity of the first variable and the second variable, and data representative of a future value of the second variable is also received. The future value of the first variable is determined using the selected model, the time-series data and the future value of the second variable.

Abstract: Computer-implemented systems and methods provide paginated search results from a multi-table database that stores hierarchically arranged data nodes. A query request is received that identifies one or more constraints and one or more monitoring attributes. Records of the multi-table database are filtered to create a view containing only records which meet the constraints. Monitoring attributes associated with a first n records of the view are accessed to generate an output view, where n is the number of records that may be displayed on a single page, and the output view is displayed on a user-viewable medium.

Abstract: Systems and methods are provided for evaluating a physical process with respect to one or more attributes of the physical process by combining forecasts for the one or more physical process attributes, where data for evaluating the physical process is generated over time. A forecast model selection graph is accessed, the forecast model selection graph comprising a hierarchy of nodes arranged in parent-child relationships. A plurality of model forecast nodes are resolved, where resolving a model forecast node includes generating a node forecast for the one or more physical process attributes. A combination node is processed, where a combination node transforms a plurality of node forecasts at child nodes of the combination node into a combined forecast. A selection node is processed, where a selection node chooses a node forecast from among child nodes of the selection node based on a selection criteria.

Abstract: Systems and methods are provided for evaluating performance of forecasting models. A plurality of forecasting models may be generated using a set of in-sample data. Two or more forecasting models from the plurality of forecasting models may be selected for use in generating a combined forecast. An ex-ante combined forecast may be generated for an out-of-sample period using the selected two or more forecasting models. The ex-ante combined forecast may then be compared with a set of actual out-of-sample data to evaluate performance of the combined forecast.

Abstract: System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member.

Abstract: An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure.

Abstract: Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

Abstract: Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.

Abstract: Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.

Abstract: Computer-implemented systems and methods for processing time series data that is indicative of a data generation activity occurring over a period of time. A model specification hierarchical data structure is used for storing characteristics that define a time series model. A fitted model hierarchical data structure stores characteristics that define a fitted time series model. The characteristics of the fitted time series model are defined through an application of the time series model to the time series data.

Abstract: Computer-implemented systems and methods for processing time series data that is indicative of a data generation activity occurring over a period of time. A model specification hierarchical data structure is used for storing characteristics that define a time series model. A fitted model hierarchical data structure stores characteristics that define a fitted time series model. The characteristics of the fitted time series model are defined through an application of the time series model to the time series data.

Abstract: Systems and methods are provided for segmenting time-series data stored in data segments containing one or more data records. A combined segment error measure is determined based on a proposed combination of two candidate segments. An error cost to merge the two candidate segments is determined based on a difference between the combined segment error measure and a segment error measure of one of the segments. The two candidate segments are combined when the error cost to merge meets a merge threshold to generate a combined segment.

Abstract: Computer-implemented systems and methods to process time-series data. As an example, a system and method can use a first data store to store time series data, and a second data store to store definitions of events. A dummy variable is generated when data from an event's definition is applied to time series data.

Abstract: Computer-implemented systems and methods are provided for implementing a scenario analysis manager that performs multiple scenarios based upon time series data that is representative of transactional data are provided. A system and method provides candidate predictive models for a first scenario for selection where the set of candidate predictive models includes an identification of variables associated with a model. Model selection data is received from a scenario analysis manager where a selected model is configured to predict a future value of a first variable based on values of a second variable. Time series data is received representative of past transaction activity of the first variable and the second variable, and data representative of a future value of the second variable is also received. The future value of the first variable is determined using the selected model, the time-series data and the future value of the second variable.

Abstract: Computer-implemented systems and methods for processing time series data that is indicative of a data generation activity occurring over a period of time. A model specification hierarchical data structure is used for storing characteristics that define a time series model. A fitted model hierarchical data structure stores characteristics that define a fitted time series model. The characteristics of the fitted time series model are defined through an application of the time series model to the time series data.

Abstract: An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure.

Abstract: Computer-implemented systems and methods provide paginated search results from a multi-table database that stores hierarchically arranged data nodes. A query request is received that identifies one or more constraints and one or more monitoring attributes. Records of the multi-table database are filtered to create a view containing only records which meet the constraints. Monitoring attributes associated with a first n records of the view are accessed to generate an output view, where n is the number of records that may be displayed on a single page, and the output view is displayed on a user-viewable medium.