Abstract: The invention relates to systems and methods for estimating a patient urea level at any arbitrary time during dialysis treatment. The systems and methods use either one or more urea sensors or any two of a pH sensor, ammonia sensor, and ammonium sensor to determine an amount of urea removed by a dialysate regeneration system. The systems and methods use the amount of urea removed by the dialysate regeneration system to estimate the patient urea level.

Abstract: The invention relates to devices, systems, and methods for managing base levels, specifically bicarbonate, in an individual undergoing dialysis. The devices, systems, and methods can be compatible with a sorbent-based dialysis therapy, and open loop control of base levels in the dialysis, without sensors or feedback for controlling the introduction of bicarbonate into the dialysate. The bicarbonate levels can be controlled and personalized to a patient using certain predetermined patient parameters. Related systems, algorithms, and control systems are contemplated including the specific predetermined parameters predictive of post-dialysis bicarbonate levels.