Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for perform predictive data analysis operations. For example, certain embodiments of the present invention utilize systems, methods, and computer program products that perform predictive data analysis operations by using a cross-temporal encoding machine learning model, such as a cross-temporal encoding machine learning model that is generated by using a target intervention classification machine learning model to map outputs of the cross-temporal encoding machine learning model to historical target intervention labels, thus enabling supervised training of the cross-temporal encoding machine learning without the need for ground-truth data corresponding to the output of the cross-temporal encoding machine learning model.

Abstract: Methods, apparatuses, systems, computing devices, and/or the like are provided. An example method may include generating a plurality of encoded input data objects associated with a measurement device; generating, using at least a bidirectional Recurrent Neural Networks (RNN) machine learning model, a predictive performance data object associated with the measurement device and a plurality of predictive weight data objects associated with the predictive performance data object, and performing one or more prediction-based actions based at least in part on the predictive performance data object or the plurality of predictive weight data objects.

Abstract: Various embodiments of the present disclosure provide machine learning model-based risk prediction and treatment pathway prioritization for entities associated with a respective disparity group. Example embodiments are configured to generate, using a risk prediction model, an individual risk score for an entity of a disparity group associated with an entity cohort. Example embodiments are also configured to generate, using a disparity risk adjustment model, a disparity adjusted risk score for the entity based on the individual risk score. Example embodiments are also configured to initiate various prediction-based actions for the entity based on a comparison between the disparity adjusted risk score and a risk score threshold. Example embodiments are also configured to generate a phenotypic profile for the entity based on an evaluation data object and an image-based evaluation data object for the entity and generate a prediction-based action sequence for the entity based on the phenotypic profile.

Abstract: Various embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for generating a correlated prediction for an input data record by generating a correlation matrix based on co-occurrences associated with a plurality of reference non-correlated predictions, generating a simulation matrix comprising a plurality of simulation data records based on a number of simulation instances and the plurality of reference non-correlated predictions, generating a plurality of correlated simulation data records based on the correlation matrix and select ones of the plurality of simulation data records, generating one or more univariates based on the plurality of correlated simulation data records, and determining a correlated prediction based on a comparison of the one or more univariates and a plurality of input non-correlated probabilities associated with the input data record.

Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing predictive data analysis using semi-structured input data. Certain embodiments of the present invention utilize systems, methods, and computer program products that perform predictive data analysis using semi-structured input data using at least one of techniques using inferred codified fields and temporally-arranged codified fields.

Abstract: Various embodiments of the present disclosure provide techniques for improving causal inference modeling with respect to predictive labels in a complex predictive domain. The techniques of the present disclosure may include generating a positive cohort and a negative cohort of data objects from a dataset based on an associated with a predictive label, generating a positive cohort impact measure for the positive cohort and one or more negative cohort impact measures for the negative cohort, and generating an object impact measure for a particular data object of the negative cohort based on the positive cohort impact measure and at least one of the negative cohort impact measures.

Abstract: A method comprises: obtaining a current initial image generated by an image generator of an imaging device based on current input signals of sensors of the imaging device; and applying a transformation model to the current initial image to generate a current transformed image, wherein the transformation model is a machine-learning model that has been trained to generate transformed images that more closely resemble reference images generated by a reference image generator.

Abstract: Various embodiments of the present disclosure provide cohort prediction and activity forecasting techniques for implementing improved population analytics in various prediction domains. The techniques may include generating a documented parameter rate for an entity cohort and a predicted parameter rate for the entity cohort based on a plurality of entity-specific parameter scores. The techniques include generating a predicted documentation error for the entity cohort based on a comparison between the documented parameter rate and the predicted parameter rate and, responsive to the predicted documentation error, initiating, using one or more cohort-specific causal models, the performance of an error correction action for the entity cohort.

Abstract: Various embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for improving allocation of limited resources by determining an optimal amount of resources to allocate to resource-receiving entities in each of one or more resource-receiving entity cohorts based on non-linear causal effect predictions, and determining an optimum operation configuration based on the determined optimal amount of resource. Non-linear causal effect of selected amounts of resources assigned to specific resource-receiving entities are predicted on an outcome of interest associated with the resource-receiving entities.

Abstract: Various embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for allocating resources. The method comprises receiving, by a computing device using a resource allocation machine learning framework, historical data comprising one or more causal variables corresponding to one or more actions or inactions with respect to one or more resource-requesting entities and one or more outcomes of one or more actions, identifying, by the computing device, given ones of one or more resource-requesting entity subgroups based at least in part on the one or more causal effect predictions, and performing, by the computing device, one or more prediction-based actions based at least in part on the identification of the given one or more resource-requesting entity subgroups.

Abstract: There is a need for more effective and efficient predictive data analysis. This need can be addressed by, for example, solutions for performing cross-temporal predictive data analysis. In one example, a method includes determining a time-adjusted encoding for each temporal unit of a group of temporal units, processing each time-adjusted encoding using a cross-temporal encoding machine learning model to generate a cross-temporal encoding of the group of temporal units, and performing one or more prediction-based actions based at least in part on the cross-temporal encoding.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for converting a multilabel classification model into a sequence of a plurality of binary classification models based on a plurality of label subgroups associated with the multilabel classification model, where the label subgroups comprise an optimal subgroup size, the optimal subgroup size is generated by optimizing an optimization measure defined by a subgroup size variable and a total inner group correlation measure, and identifying label membership to a particular subgroup by using a mixed integer linear program model.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing predictive data analysis using semi-structured input data. Certain embodiments of the present invention utilize systems, methods, and computer program products that perform predictive data analysis using semi-structured input data using at least one of techniques using inferred codified fields and temporally-arranged codified fields.

Abstract: The present invention provides compositions and methods for the treatment of a serotonin receptor related disease or condition in a subject in need thereof. A composition of the invention includes at least one psychedelic compound, which is preferably a serotonin receptor agonist, and at least one secondary agent that modulates the activity of the serotonin receptor agonist, or the physiological response to the serotonin receptor agonist in the subject.

Abstract: A method comprises: obtaining a current initial image generated by an image generator of an imaging device based on current input signals of sensors of the imaging device; and applying a transformation model to the current initial image to generate a current transformed image, wherein the transformation model is a machine-learning model that has been trained to generate transformed images that more closely resemble reference images generated by a reference image generator.

Abstract: There is a need for more effective and efficient constrained-optimization-based operational load balancing. In one example, a method comprises determining constraint-satisfying operator-unit mapping arrangements that satisfy an operator unity constraint and an operator capacity constraint; for each constraint-satisfying operator-unit mapping arrangement, determining an arrangement utility measure; processing each arrangement utility measure using an optimization-based ensemble machine learning model that is configured to determine an optimal operator-unit mapping arrangement of the plurality of constraint-satisfying operator-unit mapping arrangements; and initiating the performance of one or more operational load balancing operations based on the optimal operator-unit mapping arrangement.

Abstract: There is a need for solutions for more efficient predictive data analysis systems. This need can be addressed, for example, by a system configured to receive temporal inferences for a predictive task, where each temporal inference is associated with a temporal benchmark and the temporal benchmarks include a base temporal benchmark and supplemental temporal benchmarks; generate a cross-temporal prediction for the predictive task by applying one or more cross-temporal probabilistic updates to the base temporal inference, where each cross-temporal probabilistic update is associated with a supplemental temporal benchmark; and display the cross-temporal prediction using a cross-temporal prediction interface.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing predictive data analysis with respect to input data entities that describe temporal relationships across a large number of prediction input codes. Certain embodiments of the present invention utilize systems, methods, and computer program products that perform predictive data analysis by using hybrid prediction scores that are determined based at least in part on co-occurrence-based prediction scores and temporal prediction scores, where the co-occurrence-based prediction scores are determined based at least in part on co-occurrence-based historical representation of a sequence of prediction input codes and temporal historical representation of the sequence of prediction input codes.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for perform predictive data analysis operations. For example, certain embodiments of the present invention utilize systems, methods, and computer program products that perform predictive data analysis operations by using a cross-temporal encoding machine learning model, such as a cross-temporal encoding machine learning model that is generated by using a target intervention classification machine learning model to map outputs of the cross-temporal encoding machine learning model to historical target intervention labels, thus enabling supervised training of the cross-temporal encoding machine learning without the need for ground-truth data corresponding to the output of the cross-temporal encoding machine learning model.