Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: A fitness bag of the invention includes a body that is elongated along an axis and has a generally circumferential surface, a first axial end surface, and a second axial end surface opposite the first axial end surface. The generally circumferential surface preferably has a radially constricted section between first and second radially enlarged sections. The first radially enlarged section is located between the radially constricted section and the first axial end surface while the second radially enlarged section is located between the first radially constricted section and the second axial end surface. A plurality of side handles may be arranged in radially opposed pairs along the body and oriented such that the ends of each handle extend towards the first and second axial end surfaces. The fitness bag is adapted to be placed both horizontally and vertically on the ground and struck by an appendage of the user.

Abstract: In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: A method and apparatus are provided for automatically recognizing words of spoken speech using a computer-based speech recognition system according to a dynamic semantic model. In an embodiment, the speech recognition system recognizes speech and generates one or more word strings, each of which is a hypothesis of the speech, and creates and stores a probability value or score for each of the word strings. The word strings are ordered by probability value. The speech recognition system also creates and stores, for each of the word strings, one or more keyword-value pairs that represent semantic elements and semantic values of the semantic elements for the speech that was spoken. One or more dynamic semantic rules are defined that specify how a probability value of a word string should be modified based on information about external conditions, facts, or the environment of the application in relation to the semantic values of that word string.

Abstract: A method and apparatus are provided for automatically recognizing words of spoken speech using a computer-based speech recognition system according to a dynamic semantic model. In an embodiment, the speech recognition system recognizes speech and generates one or more word strings, each of which is a hypothesis of the speech, and creates and stores a probability value or score for each of the word strings. The word strings are ordered by probability value. The speech recognition system also creates and stores, for each of the word strings, one or more keyword-value pairs that represent semantic elements and semantic values of the semantic elements for the speech that was spoken. One or more dynamic semantic rules are defined that specify how a probability value of a word string should be modified based on information about external conditions, facts, or the environment of the application in relation to the semantic values of that word string.

Abstract: A method and apparatus are provided for automatically recognizing words of spoken speech using a computer-based speech recognition system according to a dynamic semantic model. In an embodiment, the speech recognition system recognizes speech and generates one or more word strings, each of which is a hypothesis of the speech, and creates and stores a probability value or score for each of the word strings. The word strings are ordered by probability value. The speech recognition system also creates and stores, for each of the word strings, one or more keyword-value pairs that represent semantic elements and semantic values of the semantic elements for the speech that was spoken. One or more dynamic semantic rules are defined that specify how a probability value of a word string should be modified based on information about external conditions, facts, or the environment of the application in relation to the semantic values of that word string.