Patents by Inventor Michael J. Micklus

Michael J. Micklus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting of liposomes to the blood-brain barrier
    Publication number: 20020025313
    Abstract: The present invention is directed to the targeting of drugs, peptides, and proteins to the brain. Liposomes containing the compound to be delivered are coupled to antibody binding fragments which bind to receptors on the vascular endothelium of the blood-brain barrier. The targeted receptors include transferrin receptor, insulin receptor, IGF-I and IGF-II receptors, among others. Also provided are pharmaceutical compositions and methods for administering the drugs to a subject in need by means of the receptor-targeted immunoliposomes.
    Type: Application
    Filed: February 26, 2001
    Publication date: February 28, 2002
    Inventors: Michael J. Micklus, Nigel H. Greig, Stanley I. Rapoport
  • Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
    Patent number: 4119094
    Abstract: A substrate is coated with a polyvinylpyrrolidone-polyurethane interpolymer. In the method, a polyisocyanate and a polyurethane in a solvent such as methyl ethyl ketone are applied to a substrate and the solvent evaporated. If the substrate is a polyurethane, only the polyisocyanate need be employed. Polyvinylpyrrolidone in a solvent is then applied to the treated substrate and the solvent evaporated. The invention is applied, for example, to a tube such as a catheter, a condom and a peristaltic pump tube.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: October 10, 1978
    Assignee: Biosearch Medical Products Inc.
    Inventors: Michael J. Micklus, David T. Ou-Yang
  • Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
    Patent number: 4100309
    Abstract: A substrate is coated with a polyvinylpyrollidone-polyurethane interpolymer. In the method, a polyisocyanate and a polyurethane in a solvent such as methyl ethyl ketone are applied to a substrate and the solvent evaporated. If the substrate is a polyurethane, only the polyisocyanate need be employed. Polyvinylpyrollidone in a solvent is then applied to the treated substrate and the solvent evaporated. The invention is applied, for example, to a tube such as a catheter, a condom and a peristaltic pump tube.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: July 11, 1978
    Assignee: Biosearch Medical Products, Inc.
    Inventors: Michael J. Micklus, David T. Ou-Yang