Patents by Inventor Michael J. Moser

Michael J. Moser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12311020
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include mutant M2 sequences, mutant BM2 sequences, and are useful in immunogenic compositions, e.g., as a quadrivalent vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: May 27, 2025
    Assignee: FluGen, Inc.
    Inventors: Michael J. Moser, Yasuko Hatta, Pamuk Bilsel
  • Patent number: 11980662
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: May 14, 2024
    Assignee: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Publication number: 20240091337
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: December 2, 2022
    Publication date: March 21, 2024
    Applicant: FluGen, Inc.
    Inventors: Michael J. Moser, Yasuko Hatta, Pamuk Bilsel
  • Publication number: 20230295582
    Abstract: The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PA, NP, and NS gene segments having selected nucleotides and encoding proteins having amino acid sequences with selected amino aids. The invention also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus.
    Type: Application
    Filed: July 21, 2021
    Publication date: September 21, 2023
    Applicant: FluGen, Inc.
    Inventors: Michael J. MOSER, Yasuko HATTA, Pamuk BILSEL, Lindsay HILL-BATORSKI
  • Publication number: 20230256086
    Abstract: The invention provides a recombinant virus comprising an influenza viral backbone, wherein the influenza viral backbone comprises PB1, PB2, PA, NP, M, NS, HA, and NA gene segments, wherein at least one of the PB1, PB2, PA, NP, M, NS, HA, and NA gene segments comprises at least one nucleotide sequence that encodes one or more antigens. The invention provides a recombinant virus wherein the antigen is an immunogenic fragment of SARS-CoV-2 spike glycoprotein. The invention also provides a pharmaceutical formulation and a method of eliciting an immune response.
    Type: Application
    Filed: July 21, 2021
    Publication date: August 17, 2023
    Applicant: FluGen, Inc.
    Inventors: Michael J. MOSER, David J. MARSHALL, Liam I. MARSHALL, Yasuko HATTA, Pamuk BILSEL
  • Publication number: 20230099147
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include mutant M2 sequences, mutant BM2 sequences, and are useful in immunogenic compositions, e.g., as a quadrivalent vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: May 18, 2022
    Publication date: March 30, 2023
    Applicant: FluGen, Inc.
    Inventors: Michael J. MOSER, Yasuko HATTA, Pamuk Bilsel
  • Publication number: 20230029543
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: February 18, 2022
    Publication date: February 2, 2023
    Applicant: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Patent number: 11529409
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 20, 2022
    Assignee: FluGen, Inc.
    Inventors: Michael J. Moser, Yasuko Hatta, Pamuk Bilsel
  • Publication number: 20220241397
    Abstract: The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PB1, PB2, PA, NP, and NS gene segments encoding proteins having amino acid sequences with selected amino acids. Optionally, at least one of the PB1, PB2, and PA gene segments includes a cytosine to uracil promoter mutation at nucleotide position 4. The invention el also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus.
    Type: Application
    Filed: June 5, 2020
    Publication date: August 4, 2022
    Applicant: FLUGEN, INC.
    Inventors: Yasuko HATTA, Michael J. MOSER, Pamuk BILSEL
  • Patent number: 11344616
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include mutant M2 sequences, mutant BM2 sequences, and are useful in immunogenic compositions, e.g., as a quadrivalent vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: May 31, 2022
    Assignee: FluGen, Inc.
    Inventors: Michael J. Moser, Yasuko Hatta, Pamuk Bilsel
  • Patent number: 11253584
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: February 22, 2022
    Assignee: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Publication number: 20210023197
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 28, 2021
    Applicant: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Publication number: 20200282045
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: February 26, 2018
    Publication date: September 10, 2020
    Applicant: FluGen, Inc.
    Inventors: Michael J. Moser, Yasuko Hatta, Pamuk Bilsel
  • Publication number: 20200254085
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include mutant M2 sequences, mutant BM2 sequences, and are useful in immunogenic compositions, e.g., as a quadrivalent vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: February 26, 2018
    Publication date: August 13, 2020
    Applicant: FluGen, Inc.
    Inventors: Michael J. MOSER, Yasuko HATTA, Pamuk Bilsel
  • Patent number: 10500267
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: December 10, 2019
    Assignee: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Publication number: 20180043007
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 15, 2018
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Patent number: 9757446
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: September 12, 2017
    Assignee: FLUGEN, INC.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Publication number: 20170106077
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Application
    Filed: March 13, 2015
    Publication date: April 20, 2017
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Patent number: 9249455
    Abstract: Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 2, 2016
    Assignee: LUMINEX CORPORATION
    Inventors: Michael J. Moser, Vecheslav A. Elagin
  • Publication number: 20100086908
    Abstract: The present invention relates generally to the field of nucleic acid detection and more specifically to the detection of human respiratory viruses in a patient sample. In some aspects, the invention relates to the detection of multiple respiratory viral groups, including rhinovirus, respiratory syncytial virus, parainfluenza virus, influenza virus, metapneumovirus, adenovirus, coronavirus, and enterovirus.
    Type: Application
    Filed: May 16, 2008
    Publication date: April 8, 2010
    Inventors: James R. Prudent, David J. Marshall, Wai-Ming Lee, James Gern, Michael J. Moser, Edward L. Beaty, Gerda Harms