Abstract: Various cannulated bone implants and methods of using the cannulated bone implant are disclosed. The cannulated bone implant can include a proximal portion, a proximal end, a distal portion, a distal end, a transition portion, a threaded portion, a finned portion and a central passage. The transition portion can comprise a bend positioned between the proximal portion and the distal portion. The threaded portion can be positioned along the proximal portion between the proximal end and the transition portion. The threaded portion can be configured to secure the implant into a bone of a patient. The finned portion can be positioned along the distal portion between the transition portion and the distal end. The finned portion can be configured to prevent migration and/or rotation of the implant in use. The central passage can extend linearly from the proximal end of the implant to the distal end of the implant.

Abstract: Various cannulated bone implants and methods of using the cannulated bone implant are disclosed. The cannulated bone implant can include a proximal portion, a proximal end, a distal portion, a distal end, a transition portion, a threaded portion, a finned portion and a central passage. The transition portion can comprise a bend positioned between the proximal portion and the distal portion. The threaded portion can be positioned along the proximal portion between the proximal end and the transition portion. The threaded portion can be configured to secure the implant into a bone of a patient. The finned portion can be positioned along the distal portion between the transition portion and the distal end. The finned portion can be configured to prevent migration and/or rotation of the implant in use. The central passage can extend linearly from the proximal end of the implant to the distal end of the implant.

Abstract: A transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged along an axis, a first support plate positioned between inward facing surfaces of the first magnet plate and the second magnet plate, a second support plate positioned along an outward facing surface of the first magnet plate to form a first magnetic gap between the first support plate and the second support plate, and a third support plate positioned along an outward facing surface of the second magnet plate to form a second magnetic gap between the first support plate and the third support plate; a voice coil coupled to the magnet motor assembly, wherein the voice coil is positioned around the first support plate and within the first magnetic gap and the second magnetic gap; and a piston coupled to the voice coil, wherein the piston is operable to vibrate in a direction parallel to the axis.

Abstract: A transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged along an axis, a first support plate positioned between inward facing surfaces of the first magnet plate and the second magnet plate, a second support plate positioned along an outward facing surface of the first magnet plate to form a first magnetic gap between the first support plate and the second support plate, and a third support plate positioned along an outward facing surface of the second magnet plate to form a second magnetic gap between the first support plate and the third support plate; a voice coil coupled to the magnet motor assembly, wherein the voice coil is positioned around the first support plate and within the first magnetic gap and the second magnetic gap; and a piston coupled to the voice coil, wherein the piston is operable to vibrate in a direction parallel to the axis.

Abstract: A transducer assembly including a stiffener plate having a first side and a second side; a voice coil coupled to the second side of the stiffener plate; a magnet assembly positioned along the second side of the stiffener, the magnet assembly operable to produce a magnetic field that causes a movement of the magnet assembly relative to the voice coil; and a spring suspending the magnet assembly from the stiffener plate such that the movement of the magnet assembly drives a movement of the stiffener plate.

Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.

Abstract: The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

Abstract: The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

Abstract: A dual function transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged in parallel to one another along a first axis; a sound output assembly coupled to the magnet motor assembly, the sound output assembly comprising a piston and a voice coil, and wherein the voice coil is arranged to cause a vibration of the piston in a direction parallel to the first axis; and a shaker assembly coupled to the magnet motor assembly, the shaker assembly comprising a first shaker coil and a second shaker coil arranged to cause a vibration of the magnet assembly in a direction parallel to a second axis that is perpendicular to the first axis.

Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.

Abstract: An automated funds management system and in particular a system and a method to at least ensure the payment of guaranteed minimum income benefit (“GMIB”) based on the automated sector based allocation of funds in a variable annuity. A contract holder's profile data is evaluated and a profile score is computed based on the evaluated profile data. The GMIB payment stream value is computed based on the available profile data and the assigned profile score. An appropriate asset class percentage allocation of contract holder funds is recommended based on the assigned profile score and the computed GMIB payment stream value. Appropriate subaccounts are identified based on the defined asset class percentage allocation of contract holder funds, GMIB payment stream value, and/or profile score.

Abstract: A transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged along an axis, a first support plate positioned between inward facing surfaces of the first magnet plate and the second magnet plate, a second support plate positioned along an outward facing surface of the first magnet plate to form a first magnetic gap between the first support plate and the second support plate, and a third support plate positioned along an outward facing surface of the second magnet plate to form a second magnetic gap between the first support plate and the third support plate; a voice coil coupled to the magnet motor assembly, wherein the voice coil is positioned around the first support plate and within the first magnetic gap and the second magnetic gap; and a piston coupled to the voice coil, wherein the piston is operable to vibrate in a direction parallel to the axis.

Abstract: A dual function transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged in parallel to one another along a first axis; a sound output assembly coupled to the magnet motor assembly, the sound output assembly comprising a piston and a voice coil, and wherein the voice coil is arranged to cause a vibration of the piston in a direction parallel to the first axis; and a shaker assembly coupled to the magnet motor assembly, the shaker assembly comprising a first shaker coil and a second shaker coil arranged to cause a vibration of the magnet assembly in a direction parallel to a second axis that is perpendicular to the first axis.

Abstract: A transducer assembly including a stiffener plate having a first side and a second side; a voice coil coupled to the second side of the stiffener plate; a magnet assembly positioned along the second side of the stiffener, the magnet assembly operable to produce a magnetic field that causes a movement of the magnet assembly relative to the voice coil; and a spring suspending the magnet assembly from the stiffener plate such that the movement of the magnet assembly drives a movement of the stiffener plate.

Abstract: An input device, such as a stylus, can include a main body comprising a main body connector for connecting to a charger to charge a power source of the stylus. A separate functional end module is removable from the main body to expose the main body connector. The functional end module includes a functional component and a module connector that communicates with the main body via the main body connector. Various different functional end modules can be interchangeable to provide a variety of distinct features to the stylus.

Abstract: The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered eubacterial minicells designed to preferentially target and deliver therapeutically relevant agents using a minicell surface coupling molecule capable of binding and displaying antibodies or other Fc-containing targeting moiety fusions and conjugates.

Abstract: A transducer assembly including a stiffener plate having a first side and a second side; a voice coil coupled to the second side of the stiffener plate; a magnet assembly positioned along the second side of the stiffener, the magnet assembly operable to produce a magnetic field that causes a movement of the magnet assembly relative to the voice coil; and a spring suspending the magnet assembly from the stiffener plate such that the movement of the magnet assembly drives a movement of the stiffener plate.

Abstract: A transducer assembly including a stiffener plate having a first side and a second side; a voice coil coupled to the second side of the stiffener plate; a magnet assembly positioned along the second side of the stiffener, the magnet assembly operable to produce a magnetic field that causes a movement of the magnet assembly relative to the voice coil; and a spring suspending the magnet assembly from the stiffener plate such that the movement of the magnet assembly drives a movement of the stiffener plate.

Abstract: The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.