Patents by Inventor Michael J. NOLD

Michael J. NOLD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analysis of complex biological matrices through targeting and advanced precursor and product ion alignment
    Patent number: 10495647
    Abstract: A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. Multiple cycles of operation are performed as the sample elutes from the separation device. Each cycle of operation comprises mass analysing the parent ions to obtain parent ion mass spectral data, and mass analysing fragment or product ions derived from the parent ion to obtain fragment or product ion mass spectral data. Each cycle of operation also comprises mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a first range to obtain first fragment or product ion mass spectral data, and mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a second different range to obtain second fragment or product ion mass spectral data. The method can provide a hybrid data independent acquisition (DIA) and data dependent acquisition (DDA) approach.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: December 3, 2019
    Assignee: Waters Technologies Corporation
    Inventors: Scott J Geromanos, Steven J Ciavarini, James I. Langridge, Brad J Williams, Michael J Nold
  • Analysis of Complex Biological Matrices Through Targeting and Advanced Precursor and Product Ion Alignment
    Publication number: 20170108508
    Abstract: A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. Multiple cycles of operation are performed as the sample elutes from the separation device. Each cycle of operation comprises mass analysing the parent ions to obtain parent ion mass spectral data, and mass analysing fragment or product ions derived from the parent ion to obtain fragment or product ion mass spectral data. Each cycle of operation also comprises mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a first range to obtain first fragment or product ion mass spectral data, and mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a second different range to obtain second fragment or product ion mass spectral data. The method can provide a hybrid data independent acquisition (DIA) and data dependent acquisition (DDA) approach.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 20, 2017
    Inventors: Scott J. GEROMANOS, Steven J. CIAVARINI, James I. LANGRIDGE, Brad J. WILLIAMS, Michael J. NOLD