Patents by Inventor Michael J. Otto

Michael J. Otto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10423603
    Abstract: A method includes determining, by a processor, whether a program check condition exists. The method further includes determining, by the processor, whether a lock descriptor of a lock in a file lock table satisfies an unlocking condition. The method further includes releasing, by the processor, the lock by setting the lock descriptor's host identifier as zero. The method further includes determining, by the processor, whether any lock in the file lock table satisfies a lock conflict condition. The method further includes determining, by the processor, whether the file lock table includes any lock descriptor that satisfies a locking condition. The method further includes creating, by the processor, a new lock using the lock descriptor that satisfies the locking condition.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: September 24, 2019
    Assignee: Unisys Corporation
    Inventors: Michael C Otto, Carl R Crandall, Forest F Crocker, Lnda J Brock, Douglas A Fuller, Michael J Rieschl
  • Patent number: 8716197
    Abstract: Adding a lubricant having a metal stearate and polytetrafluoroethylene (PTFE) to a downhole fluid may lubricate a first surface once the downhole fluid has been circulated within a subterranean reservoir wellbore. Friction, torque, and/or drag may be reduced when the lubricated first surface contacts a second surface. The first surface may be or include, but is not limited to a wellbore casing, a drill string, a pipe, a formation, a drill bit, a metal surface within a mud motor, formation evaluation tool, at least one drilling tool, and combinations thereof. One or both of the first and second surfaces may be metal. The downhole fluid may be or include, but is not limited to, a drilling fluid, a completion fluid, a fracturing fluid, a drill-in fluid, a workover fluid, and combinations thereof.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: May 6, 2014
    Assignee: Baker Hughes Incorporated
    Inventors: Michael J. Otto, Dennis K. Clapper
  • Publication number: 20130217602
    Abstract: Adding a lubricant having a metal stearate and polytetrafluoroethylene (PTFE) to a downhole fluid may lubricate a first surface once the downhole fluid has been circulated within a subterranean reservoir wellbore. Friction, torque, and/or drag may be reduced when the lubricated first surface contacts a second surface. The first surface may be or include, but is not limited to a wellbore casing, a drill string, a pipe, a formation, a drill bit, a metal surface within a mud motor, formation evaluation tool, at least one drilling tool, and combinations thereof. One or both of the first and second surfaces may be metal. The downhole fluid may be or include, but is not limited to, a drilling fluid, a completion fluid, a fracturing fluid, a drill-in fluid, a workover fluid, and combinations thereof.
    Type: Application
    Filed: August 17, 2012
    Publication date: August 22, 2013
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Michael J. Otto, Dennis K. Clapper
  • Patent number: 8273689
    Abstract: Lubricants and drilling fluid systems comprising lubricants which form a coherent lubricating film on metal equipment, thereby prolonging equipment life even under a wide variety of conditions, including high temperature and/or high pressure conditions.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: September 25, 2012
    Assignee: Baker Hughes Incorporated
    Inventors: Michael J. Otto, James E. Norfleet, Dennis K. Clapper, Kalyan C. Singamshetty
  • Publication number: 20120202766
    Abstract: The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N.sup.4-acyl-2?,3?-dideoxy-5-fluorocytidine or N.sup.4-acyl-2?,3?-didehyd-ro-2?,3?-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 9, 2012
    Applicant: Pharmasset, Inc.
    Inventors: Michael J. Otto, Junxing Shi, Kyoichi A. Watanabe
  • Patent number: 8114997
    Abstract: The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N.sup.4-acyl-2?,3?-dideoxy-5-fluorocytidine or N.sup.4-acyl-2?,3?-didehyd-ro-2?,3?-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: February 14, 2012
    Assignee: Pharmasset, Inc.
    Inventors: Michael J. Otto, Junxing Shi, Kyoichi A. Watanabe
  • Patent number: 7919247
    Abstract: A process for assessing mitochondrial toxicity of a compound that includes contacting nucleic acids from a host with an amplification reaction mixture that contains at least two primers that provide detectable signals, wherein: a first primer provides a first detectable signal upon amplification of a host mitochondrial nucleic acid; a second primer provides a second detectable signal upon amplification of a host nuclear nucleic acid; and comparing the first and second detectable signals.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: April 5, 2011
    Assignee: Pharmasset, Inc.
    Inventors: Lieven Stuyver, Michael J. Otto
  • Patent number: 7718790
    Abstract: Processes and methods for the simultaneous quantification of nucleic acids in diseased cells that are based on real-time PCR are provided. The real-time PCR protocol is an excellent tool for reliable quantification of in vitro drug screening and evaluation protocols to determine the efficacy of potential anti-viral agents. Quantification using these simultaneous PCR cycle threshold (Ct) detection techniques during one-step real-time RT-PCR (Applied Biosystems, CA) eliminates the variability resulting from quantification of end-point RT-PCR products. In addition, the mitochondrial toxicity assay is an added tool to assess potential side-effects for these chemotherapeutic agents.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 18, 2010
    Assignee: Pharmasset, Inc.
    Inventors: Lieven Stuyver, Michael J. Otto
  • Patent number: 7681559
    Abstract: A torsion damping mechanism for a rotary blower is provided that has improved durability and ease of installation into the rotary blower. A rotary blower including a torsion damping mechanism according to an embodiment of the present invention is also provided.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: March 23, 2010
    Assignee: Eaton Corporation
    Inventors: Mark H. Pratley, Michael J. Otto
  • Publication number: 20090220950
    Abstract: Processes and methods for the simultaneous quantification of nucleic acids in diseased cells that are based on real-time PCR are provided. The real-time PCR protocol is an excellent tool for reliable quantification of in vitro drug screening and evaluation protocols to determine the efficacy of potential anti-viral agents. Quantification using these simultaneous PCR cycle threshold (Ct) detection techniques during one-step real-time RT-PCR (Applied Biosystems, CA) eliminates the variability resulting from quantification of end-point RT-PCR products. In addition, the mitochondrial toxicity assay is an added tool to assess potential side-effects for these chemotherapeutic agents.
    Type: Application
    Filed: December 3, 2007
    Publication date: September 3, 2009
    Applicant: Pharmasset, Inc.
    Inventors: LIEVEN STUYVER, Michael J. Otto
  • Publication number: 20090176730
    Abstract: The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N.sup.4-acyl-2?,3?-dideoxy-5-fluorocytidine or N.sup.4-acyl-2?,3?-didehydro-2?,3?-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Application
    Filed: January 4, 2008
    Publication date: July 9, 2009
    Applicant: Pharmasset, Inc.
    Inventors: Michael J. Otto, Junxing Shi, Kyoichi A. Watanabe
  • Publication number: 20080149452
    Abstract: A torsion damping mechanism for a rotary blower is provided that has improved durability and ease of installation into the rotary blower. A rotary blower including a torsion damping mechanism according to an embodiment of the present invention is also provided.
    Type: Application
    Filed: December 21, 2006
    Publication date: June 26, 2008
    Inventors: Mark H. Pratley, Michael J. Otto
  • Patent number: 7105527
    Abstract: The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acyl-2?,3?-dideoxy-5-fluorocytidine or N4-acyl-2?,3?-didehydro-2?,3?-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: September 12, 2006
    Inventors: Michael J. Otto, Junxing Shi, Kyoichi A. Watanabe
  • Patent number: 6949522
    Abstract: The present invention includes compounds and compositions of ?-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: September 27, 2005
    Assignees: Pharmasset, Inc., The University of Georgia Research Foundation, Inc., Emory University
    Inventors: Michael J. Otto, Junxing Shi, Chung K. Chu, Raymond F. Schinazi, Giuseppe Gumina, Youhoon Chong, Yongseok Choi
  • Patent number: 6908924
    Abstract: The present invention is directed to a compound, method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acylcytosine-1,3-dioxolane and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: June 21, 2005
    Assignee: Pharmasset, Inc.
    Inventors: Kyoichi A. Watanabe, Junxing Shi, Michael J. Otto
  • Publication number: 20040266723
    Abstract: The disclosed invention is a composition for and a method of treating Flaviviridae (Hepacivirus, Flavivirus, Pestivirus) infections, including BVDV and HCV, in a host, including animals, and especially humans, using a small molecule or its pharmaceutically acceptable salt or prodrug.
    Type: Application
    Filed: December 17, 2001
    Publication date: December 30, 2004
    Inventors: Michael J. Otto, Kyoichi A. Watanabe, Steve Patterson, Krysztof W. Pankiewicz, Lieven Stuyver
  • Publication number: 20040214844
    Abstract: The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acyl-2′,3′-dideoxy-5-fluorocytidine or N4-acyl-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Application
    Filed: December 13, 2002
    Publication date: October 28, 2004
    Inventors: Michael J. Otto, Junxing Shi, Kyoichi A. Watanabe
  • Publication number: 20030176319
    Abstract: The present invention is directed to a compound, method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acylcytosine-1,3-dioxolane and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Application
    Filed: December 16, 2002
    Publication date: September 18, 2003
    Inventors: Kyoichi A. Watanabe, Junxing Shi, Michael J. Otto
  • Patent number: 5616578
    Abstract: This invention relates to a method of treating human immunodeficiency virus (HIV) infection in a mammal comprising administering to the mammal a therapeutically effective amount of a combination of: (i) at least one cyclic HIV protease inhibitor and (ii) at least one HIV reverse transcriptase inhibitor.
    Type: Grant
    Filed: August 26, 1993
    Date of Patent: April 1, 1997
    Assignee: The Dupont Merck Pharmaceutical Company
    Inventor: Michael J. Otto
  • Patent number: RE42015
    Abstract: The present invention is directed to a compound, method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acylcytosine-1,3-dioxolane and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: December 28, 2010
    Assignee: Pharmasset, Inc.
    Inventors: Kyoichi A. Watanabe, Junxing Shi, Michael J. Otto