Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A medical vest (10) and a method of using the vest to provide emergency medical care to a patient (102), are described. The vest includes an IV container (28) and a medical supply container (58) which are mounted on mounting pads (22, 24 or 26) on the front (12) or back (14) of the vest. The containers are also connected to the shoulders (16) of the vest by shoulder straps (27). The IV container is configured to carry an IV bag (150) as well as all the medical supplies necessary to provide an IV to a patient. The container is constructed so as to remain in the open position to allow the user to use both hands to tend to the patient. A clip strap (46) with a self-closing hook (48) is provided with the container to allow the container to be hooked near a patient for transport with the patient. The medical supply container has a variety of uses and can be provided with inserts with loops (69) for holding airway equipment or inserts without loops to hold additional emergency medical supplies.

Abstract: A medical vest (10) and a method of using the vest to provide emergency medical care to a patient (102), are described. The vest includes an IV container (28) and a medical supply container (58) which are mounted on mounting pads (22, 24 or 26) on the front (12) or back (14) of the vest. The containers are also connected to the shoulders (16) of the vest by shoulder straps (27). The IV container is configured to carry an IV bag (150) as well as all the medical supplies necessary to provide an IV to a patient. The container is constructed so as to remain in the open position to allow the user to use both hands to tend to the patient. A clip strap (46) with a self-closing hook (48) is provided with the container to allow the container to be hooked near a patient for transport with the patient. The medical supply container has a variety of uses and can be provided with inserts with loops (69) for holding airway equipment or inserts without loops to hold additional emergency medical supplies.

Abstract: A medical vest (10) and a method of using the vest to provide emergency medical care to a patient (102), are described. The vest includes an IV container (28) and a medical supply container (58) which are mounted on mounting pads (22, 24 or 26) on the front (12) or back (14) of the vest. The containers are also connected to the shoulders (16) of the vest by shoulder straps (27). The IV container is configured to carry an IV bag (150) as well as all the medical supplies necessary to provide an IV to a patient. The container is constructed so as to remain in the open position to allow the user to use both hands to tend to the patient. A clip strap (46) with a self-closing hook (48) is provided with the container to allow the container to be hooked near a patient for transport with the patient. The medical supply container has a variety of uses and can be provided with inserts with loops (69) for holding airway equipment or inserts without loops to hold additional emergency medical supplies.

Abstract: A medical vest (10) and a method of using the vest to provide emergency medical care to a patient (102), are described. The vest includes an IV container (28) and a medical supply container (58) which are mounted on mounting pads (22, 24 or 26) on the front (12) or back (14) of the vest. The containers are also connected to the shoulders (16) of the vest by shoulder straps (27). The IV container is configured to carry an IV bag (150) as well as all the medical supplies necessary to provide an IV to a patient. The container is constructed so as to remain in the open position to allow the user to use both hands to tend to the patient. A clip strap (46) with a self-closing hook (48) is provided with the container to allow the container to be hooked near a patient for transport with the patient. The medical supply container has a variety of uses and can be provided with inserts with loops (69) for holding airway equipment or inserts without loops to hold additional emergency medical supplies.