Abstract: Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.

Abstract: The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.

Abstract: PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.

Abstract: The invention provides reagents and methods for conjugating a polymer specifically to the &agr;-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the &agr;-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.

Abstract: An apparatus for measuring the inductance of a wire-loop with noise-cancellation, auto-calibration and wireless communication features, or detector circuit. The apparatus measures the effective change in inductance induced in a wire-loop as a vehicle passes over the wire-loop to produce an inductive signature corresponding to a vehicle.

Abstract: The invention provides reagents and methods for conjugating polymers specifically to the &agr;-amine of polypeptides in high yield. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a thioester moiety capable of specifically conjugating to the &agr;-amine of a polypeptide having a cysteine or histidine at the N-terminus. The invention provides active thioester derivatives of PEG that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG and polypeptide. Use of these active esters to prepare PEG-proteins and PEG-peptides is described.

Abstract: An apparatus for measuring the inductance of a wire-loop with noise-cancellation, auto-calibration and wireless communication features, or detector circuit. The apparatus measures the effective change in inductance induced in a wire-loop as a vehicle passes over the wire-loop to produce an inductive signature corresponding to a vehicle.

Abstract: The present invention provides IgG monoclonal antibodies and IgG monoclonal antibody fragments that selectively bind to PEG, hybridoma cell lines and methods for producing these antibodies, and methods for using the PEG-selective monoclonal antibodies. The methods of the invention include methods for detecting molecules, viruses, cells, or organelles that contain at least one poly(ethylene glycol) group and methods for purifying for purifying molecules, viruses, cells, or organelles that contain at least one poly(ethylene glycol) group. Also provided are methods for using the anti-PEG monoclonal antibodies in vivo to modulate the level of a PEG-containing molecule.

Abstract: A process and apparatus for combustion in which a combustible material is introduced into a combustion chamber and oxidant is supplied to the combustion chamber. The combustible material is burned, and forming a primary combustion zone. A mixture of flue gases and flyash having an organic content is injected into the combustion chamber downstream of the primary combustion zone to create an oxygen-deficient reburn zone, thereby lowering the temperature of combustion, reducing the NO.sub.x content of the flue gases, and reducing the potential for NO.sub.x formation in a tertiary oxidizing combustion zone disposed downstream of the oxygen-deficient reburn zone.

Abstract: A process for combustion of a combustible material in which a primary combustible material is introduced into a combustion chamber having an upstream region and a downstream region, and ignited, forming a primary combustion zone. A secondary combustible material is partially combusted in a partial combustor, forming partial combustion products which are then injected into the combustion chamber downstream of the primary combustion zone, forming an oxygen deficient zone downstream of the primary combustion zone.

Abstract: A dual-mode Johnson noise and DC resistance thermometer capable of use in control systems where prompt indications of temperature changes and long term accuracy are needed. A resistance-inductance-capacitance (RLC) tuned circuit produces a continuous voltage signal for Johnson noise temperature measurement. The RLC circuit provides a mean-squared noise voltage that depends only on the capacitance used and the temperature of the sensor. The sensor has four leads for simultaneous coupling to a noise signal processor and to a DC resistance signal processor.

Abstract: Method and device for direct, non-contact temperature measure of a body. A laser beam is reflected from the surface of the body and detected along with the Planck radiation. The detected signal is analyzed using signal correlation technique to generate an output signal proportional to the Johnson noise introduced into the reflected laser beam as a direct measure of the absolute temperature of the body.

Abstract: An automatic data plotting apparatus consists of three main parts: a processor; a serial and parallel interface; and a plotter. The plotter is a flat-bed X-Y plotter. The data processor is programmed to handle one or more data inputs and instruct the plotter to record information relating to the data inputs on a plot. The processor translates the incoming data into times, bearings, tracks and any other characteristics. A pause facility is provided to suspend plotting, the incoming data being stored in a data store while the pause facility is in operation and being recorded on the plot when the pause is discontinued. An automatic data plotting apparatus provides a focal point at which incoming information can be co-ordinated and displayed. The displayed information can then be evaluated and/or stored for later analysis.

Abstract: The life of a joint in splice jointed conveyor belting is increased by providing a belting wherein the joint is protected by a covering of a breaker fabric having substantially different stretch characteristics in warp and weft directions. A suitable breaker fabric is a warp knitted fabric having a warp to weft elongation ratio of from 1:2 to 1:30, preferably 1:3 to 1:20, for example approximately 1:15. The conveyor belting may comprise a solid woven textile fabric core impregnated and/or coated with polyvinyl chloride and the joint may be one formed by finger splicing.