Patents by Inventor Michael J. Rust
Michael J. Rust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10794828Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: GrantFiled: August 8, 2018Date of Patent: October 6, 2020Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Publication number: 20190242823Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: August 8, 2018Publication date: August 8, 2019Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Patent number: 10201652Abstract: A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.Type: GrantFiled: April 19, 2013Date of Patent: February 12, 2019Assignee: FloDesign Sonics, Inc.Inventors: Brian Dutra, Bart Lipkens, Daniel Kennedy, Michael J. Rust
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Patent number: 10073035Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: GrantFiled: August 31, 2016Date of Patent: September 11, 2018Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Patent number: 9921209Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.Type: GrantFiled: January 20, 2017Date of Patent: March 20, 2018Assignee: WESTERN NEW ENGLAND UNIVERSITYInventors: Ronny Priefer, Michael J. Rust
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Publication number: 20170131260Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.Type: ApplicationFiled: January 20, 2017Publication date: May 11, 2017Inventors: Ronny Priefer, Michael J. Rust
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Patent number: 9581585Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.Type: GrantFiled: October 31, 2014Date of Patent: February 28, 2017Assignee: WESTERN NEW ENGLAND UNIVERSITYInventors: Ronny Priefer, Michael J. Rust
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Publication number: 20160370295Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: August 31, 2016Publication date: December 22, 2016Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Publication number: 20150177224Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.Type: ApplicationFiled: October 31, 2014Publication date: June 25, 2015Inventors: Ronny Priefer, Michael J. Rust
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Publication number: 20140326922Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: December 9, 2013Publication date: November 6, 2014Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Publication number: 20130001436Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: July 17, 2012Publication date: January 3, 2013Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Publication number: 20120009589Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: July 11, 2011Publication date: January 12, 2012Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang, Graham Thomas Dempsey
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Publication number: 20100316269Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: June 7, 2010Publication date: December 16, 2010Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
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Publication number: 20100297777Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: August 4, 2010Publication date: November 25, 2010Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang, Graham Thomas Dempsey
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Patent number: 7838302Abstract: The present invention generally relates to sub-diffraction limit image resolution. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc.Type: GrantFiled: February 1, 2008Date of Patent: November 23, 2010Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang
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Patent number: 7776613Abstract: The present invention generally relates to sub-diffraction image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction resolution.Type: GrantFiled: November 29, 2006Date of Patent: August 17, 2010Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred Mark Bates, Michael J. Rust
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Publication number: 20080182336Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.Type: ApplicationFiled: February 1, 2008Publication date: July 31, 2008Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang
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Patent number: D812474Type: GrantFiled: July 29, 2016Date of Patent: March 13, 2018Assignee: 3M Innovative Properties CompanyInventors: Michael J. Rust, Patrick R. McKellips
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Patent number: D838166Type: GrantFiled: November 22, 2017Date of Patent: January 15, 2019Assignee: 3M Innovative Properties CompanyInventors: Michael J. Rust, Patrick R. McKellips
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Patent number: D876237Type: GrantFiled: November 15, 2018Date of Patent: February 25, 2020Assignee: 3M Innovative Properties CompanyInventors: Michael J. Rust, Patrick R. McKellips