Patents by Inventor Michael J. Rust

Michael J. Rust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10794828
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: October 6, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Publication number: 20190242823
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: August 8, 2018
    Publication date: August 8, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Patent number: 10201652
    Abstract: A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 12, 2019
    Assignee: FloDesign Sonics, Inc.
    Inventors: Brian Dutra, Bart Lipkens, Daniel Kennedy, Michael J. Rust
  • Patent number: 10073035
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: September 11, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Patent number: 9921209
    Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: March 20, 2018
    Assignee: WESTERN NEW ENGLAND UNIVERSITY
    Inventors: Ronny Priefer, Michael J. Rust
  • Publication number: 20170131260
    Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.
    Type: Application
    Filed: January 20, 2017
    Publication date: May 11, 2017
    Inventors: Ronny Priefer, Michael J. Rust
  • Patent number: 9581585
    Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: February 28, 2017
    Assignee: WESTERN NEW ENGLAND UNIVERSITY
    Inventors: Ronny Priefer, Michael J. Rust
  • Publication number: 20160370295
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 22, 2016
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Publication number: 20150177224
    Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.
    Type: Application
    Filed: October 31, 2014
    Publication date: June 25, 2015
    Inventors: Ronny Priefer, Michael J. Rust
  • Publication number: 20140326922
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: December 9, 2013
    Publication date: November 6, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Publication number: 20130001436
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 3, 2013
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Publication number: 20120009589
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 12, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang, Graham Thomas Dempsey
  • Publication number: 20100316269
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 16, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust
  • Publication number: 20100297777
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: August 4, 2010
    Publication date: November 25, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang, Graham Thomas Dempsey
  • Patent number: 7838302
    Abstract: The present invention generally relates to sub-diffraction limit image resolution. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 23, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang
  • Patent number: 7776613
    Abstract: The present invention generally relates to sub-diffraction image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction resolution.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: August 17, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred Mark Bates, Michael J. Rust
  • Publication number: 20080182336
    Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 31, 2008
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang
  • Patent number: D812474
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: March 13, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Michael J. Rust, Patrick R. McKellips
  • Patent number: D838166
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: January 15, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Michael J. Rust, Patrick R. McKellips
  • Patent number: D876237
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: February 25, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Michael J. Rust, Patrick R. McKellips